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• W4311762973 endingPage "104969" @default.
• W4311762973 startingPage "104969" @default.
• W4311762973 abstract "In recent years, significant progress in hemorheological modeling has occurred after the development of constitutive models able to represent the major physical mechanisms that govern the interaction, deformation, and motion of blood cells and plasma. Only a few of them have a tensorial form and can be applied in complex multidimensional flows, allowing a better understanding of hemodynamics and the evolution of biological processes in tissues. In this research, the pulsatile blood flow in 3D rigid aneurysmal geometries is studied in silico, employing our integrated elasto-viscoplastic constitutive model with thixotropy (TEVP), the parameters of which have been evaluated for normal blood subjects. Blood flow is investigated under sinusoidal waveforms with different frequencies and amplitudes, providing a thorough parametric study. As pulse frequency increases, the variation of the structure parameter decreases, and a recirculation is formed inside the aneurysmal dome. Moreover, a significantly higher value of the wall shear stress (WSS) develops around the mouth of the aneurysm, potentially leading to a progressive increase in the size of a real sack. Interestingly, WSS exhibits spatial oscillations and attains higher amplitudes along the part of the tube wall beside the aneurysm, where an instability is developed. With an increase in the pulse amplitude, blood gets softer and flows more easily. At the same time, the WSS inside the aneurysm remains low enough to potentially promote a growth or rupture, since low wall-stresses have been related to these processes. The curvature of the parent vessel of the aneurysm affects the flow dynamics throughout the cycle. In contrast to the WSS, the magnitude of the total stress for the curved vessel is higher than that for the straight vessel." @default.
• W4311762973 created "2022-12-28" @default.
• W4311762973 creator A5054871629 @default.
• W4311762973 creator A5069397987 @default.
• W4311762973 date "2023-01-01" @default.
• W4311762973 modified "2023-09-26" @default.
• W4311762973 title "TEVP model predictions of the pulsatile blood flow in 3D aneurysmal geometries" @default.
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