Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311764032> ?p ?o ?g. }
- W4311764032 endingPage "45" @default.
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- W4311764032 abstract "Targeted protein degradation (TPD) is emerging as one of the most innovative strategies to tackle infectious diseases. Particularly, proteolysis-targeting chimera (PROTAC)-mediated protein degradation may offer several benefits over classical anti-infective small-molecule drugs. Because of their peculiar and catalytic mechanism of action, anti-infective PROTACs might be advantageous in terms of efficacy, toxicity, and selectivity. Importantly, PROTACs may also overcome the emergence of antimicrobial resistance. Furthermore, anti-infective PROTACs might have the potential to (i) modulate undruggable targets, (ii) recycle inhibitors from classical drug discovery approaches, and (iii) open new scenarios for combination therapies. Here, we try to address these points by discussing selected case studies of antiviral PROTACs and the first-in-class antibacterial PROTACs. Finally, we discuss how the field of PROTAC-mediated TPD might be exploited in parasitic diseases. Since no antiparasitic PROTAC has been reported yet, we also describe the parasite proteasome system. While in its infancy and with many challenges ahead, we hope that PROTAC-mediated protein degradation for infectious diseases may lead to the development of next-generation anti-infective drugs." @default.
- W4311764032 created "2022-12-28" @default.
- W4311764032 creator A5008442547 @default.
- W4311764032 creator A5026851542 @default.
- W4311764032 creator A5033718762 @default.
- W4311764032 creator A5035724638 @default.
- W4311764032 creator A5065488736 @default.
- W4311764032 creator A5069833831 @default.
- W4311764032 creator A5071863016 @default.
- W4311764032 date "2022-12-15" @default.
- W4311764032 modified "2023-10-10" @default.
- W4311764032 title "Targeted Protein Degradation for Infectious Diseases: from Basic Biology to Drug Discovery" @default.
- W4311764032 cites W1521762620 @default.
- W4311764032 cites W1535363390 @default.
- W4311764032 cites W1565539350 @default.
- W4311764032 cites W1762734860 @default.
- W4311764032 cites W1906884173 @default.
- W4311764032 cites W1969403212 @default.
- W4311764032 cites W1970826261 @default.
- W4311764032 cites W1988461431 @default.
- W4311764032 cites W1991841644 @default.
- W4311764032 cites W2007615306 @default.
- W4311764032 cites W2007954622 @default.
- W4311764032 cites W2013030981 @default.
- W4311764032 cites W2023342339 @default.
- W4311764032 cites W2030689174 @default.
- W4311764032 cites W2052972684 @default.
- W4311764032 cites W2053696392 @default.
- W4311764032 cites W2059494851 @default.
- W4311764032 cites W2062609827 @default.
- W4311764032 cites W2080161281 @default.
- W4311764032 cites W2081120309 @default.
- W4311764032 cites W2083378353 @default.
- W4311764032 cites W2084778320 @default.
- W4311764032 cites W2097148041 @default.
- W4311764032 cites W2103151604 @default.
- W4311764032 cites W2134320577 @default.
- W4311764032 cites W2139516496 @default.
- W4311764032 cites W2141211246 @default.
- W4311764032 cites W2146401071 @default.
- W4311764032 cites W2151683271 @default.
- W4311764032 cites W2158427156 @default.
- W4311764032 cites W2184708702 @default.
- W4311764032 cites W2304335366 @default.
- W4311764032 cites W2613065881 @default.
- W4311764032 cites W2621133539 @default.
- W4311764032 cites W2626245267 @default.
- W4311764032 cites W2692768525 @default.
- W4311764032 cites W2767251210 @default.
- W4311764032 cites W2767856718 @default.
- W4311764032 cites W2787000216 @default.
- W4311764032 cites W2807045797 @default.
- W4311764032 cites W2811512821 @default.
- W4311764032 cites W2893986419 @default.
- W4311764032 cites W2920302906 @default.
- W4311764032 cites W2944640816 @default.
- W4311764032 cites W2948628743 @default.
- W4311764032 cites W2966441858 @default.
- W4311764032 cites W2983047568 @default.
- W4311764032 cites W2985586364 @default.
- W4311764032 cites W2988743418 @default.
- W4311764032 cites W2989693255 @default.
- W4311764032 cites W2993071611 @default.
- W4311764032 cites W3011829967 @default.
- W4311764032 cites W3019990654 @default.
- W4311764032 cites W3033150042 @default.
- W4311764032 cites W3035199877 @default.
- W4311764032 cites W3036729042 @default.
- W4311764032 cites W3038943830 @default.
- W4311764032 cites W3082754737 @default.
- W4311764032 cites W3085433450 @default.
- W4311764032 cites W3088195034 @default.
- W4311764032 cites W3091134219 @default.
- W4311764032 cites W3094055260 @default.
- W4311764032 cites W3095840616 @default.
- W4311764032 cites W3095917078 @default.
- W4311764032 cites W3108929519 @default.
- W4311764032 cites W3127132231 @default.
- W4311764032 cites W3153520238 @default.
- W4311764032 cites W3161698207 @default.
- W4311764032 cites W3162028161 @default.
- W4311764032 cites W3163700030 @default.
- W4311764032 cites W3174097400 @default.
- W4311764032 cites W3182488106 @default.
- W4311764032 cites W3183094458 @default.
- W4311764032 cites W3186943259 @default.
- W4311764032 cites W3197910032 @default.
- W4311764032 cites W3215940941 @default.
- W4311764032 cites W3217240477 @default.
- W4311764032 cites W4205379795 @default.
- W4311764032 cites W4205424394 @default.
- W4311764032 cites W4205428265 @default.
- W4311764032 cites W4206677002 @default.
- W4311764032 cites W4210927053 @default.
- W4311764032 cites W4214809923 @default.
- W4311764032 cites W4224227858 @default.
- W4311764032 cites W4224815538 @default.
- W4311764032 cites W4225285629 @default.