Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311764520> ?p ?o ?g. }
- W4311764520 endingPage "48382" @default.
- W4311764520 startingPage "48372" @default.
- W4311764520 abstract "Photodynamic therapy (PDT) is an effective treatment modality for various cancer types. However, tumor recurrence and metastasis stemming from residual cancer cells after PDT pose serious problems. In this study, a simple multifunctional PTX@Ce6 nanomedicine is prepared using a two-step reprecipitation method. In this core-shell nanostructure, the toxic paclitaxel (PTX) core is embedded into a nontoxic Ce6 shell. An ultralow dose of PTX (1 mg/kg) stimulates the differentiation of marrow-derived suppressor cells (MDSCs) into mature dendritic cells (DCs), resulting in the restoration of functions of tumor-specific CD8+ T cells and promotion of antitumor immune responses in vivo. Hence, the tumors in mice are eradicated with 100% tumor inhibition rate via combination therapy. Tumor recurrence and metastasis are also effectively inhibited. In addition, the combination therapy with PDT and metronomic chemotherapy based on core-shell PTX@Ce6 nanostructures shows high biosafety in treated mice. This study can aid in developing new cancer treatment modalities for eradicating tumors, preventing tumor recurrence and metastasis, and reducing the systemic side effects of therapy." @default.
- W4311764520 created "2022-12-28" @default.
- W4311764520 creator A5021412121 @default.
- W4311764520 creator A5034974130 @default.
- W4311764520 creator A5037869670 @default.
- W4311764520 creator A5077459963 @default.
- W4311764520 date "2022-12-15" @default.
- W4311764520 modified "2023-09-27" @default.
- W4311764520 title "Simple Multifunctional PTX@Ce6 Nanomedicine for Eradicating Tumor in the Combination of Photodynamic Therapy and Metronomic Chemotherapy" @default.
- W4311764520 cites W1574056173 @default.
- W4311764520 cites W1976595844 @default.
- W4311764520 cites W1983906625 @default.
- W4311764520 cites W1989673842 @default.
- W4311764520 cites W2002831182 @default.
- W4311764520 cites W2004150448 @default.
- W4311764520 cites W2026250154 @default.
- W4311764520 cites W2026889493 @default.
- W4311764520 cites W2099761318 @default.
- W4311764520 cites W2125066479 @default.
- W4311764520 cites W2130166533 @default.
- W4311764520 cites W2297044638 @default.
- W4311764520 cites W2300197534 @default.
- W4311764520 cites W2329798050 @default.
- W4311764520 cites W2344598639 @default.
- W4311764520 cites W2413359062 @default.
- W4311764520 cites W2554294021 @default.
- W4311764520 cites W2560865180 @default.
- W4311764520 cites W2586843734 @default.
- W4311764520 cites W2590680367 @default.
- W4311764520 cites W2754708902 @default.
- W4311764520 cites W2789818115 @default.
- W4311764520 cites W2796781998 @default.
- W4311764520 cites W2806940039 @default.
- W4311764520 cites W2860296076 @default.
- W4311764520 cites W2900594661 @default.
- W4311764520 cites W2901550388 @default.
- W4311764520 cites W2902590722 @default.
- W4311764520 cites W2903743627 @default.
- W4311764520 cites W2919167033 @default.
- W4311764520 cites W2923949067 @default.
- W4311764520 cites W2950925637 @default.
- W4311764520 cites W2966280214 @default.
- W4311764520 cites W2986913460 @default.
- W4311764520 cites W3016789101 @default.
- W4311764520 cites W3087563930 @default.
- W4311764520 cites W3204360553 @default.
- W4311764520 cites W3209155806 @default.
- W4311764520 cites W4220967419 @default.
- W4311764520 cites W4281630788 @default.
- W4311764520 cites W4283759186 @default.
- W4311764520 cites W4292311318 @default.
- W4311764520 cites W4296058404 @default.
- W4311764520 doi "https://doi.org/10.1021/acsomega.2c06578" @default.
- W4311764520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36591126" @default.
- W4311764520 hasPublicationYear "2022" @default.
- W4311764520 type Work @default.
- W4311764520 citedByCount "1" @default.
- W4311764520 countsByYear W43117645202023 @default.
- W4311764520 crossrefType "journal-article" @default.
- W4311764520 hasAuthorship W4311764520A5021412121 @default.
- W4311764520 hasAuthorship W4311764520A5034974130 @default.
- W4311764520 hasAuthorship W4311764520A5037869670 @default.
- W4311764520 hasAuthorship W4311764520A5077459963 @default.
- W4311764520 hasBestOaLocation W43117645202 @default.
- W4311764520 hasConcept C121608353 @default.
- W4311764520 hasConcept C126322002 @default.
- W4311764520 hasConcept C15083742 @default.
- W4311764520 hasConcept C150903083 @default.
- W4311764520 hasConcept C155672457 @default.
- W4311764520 hasConcept C171250308 @default.
- W4311764520 hasConcept C178790620 @default.
- W4311764520 hasConcept C185592680 @default.
- W4311764520 hasConcept C192562407 @default.
- W4311764520 hasConcept C207001950 @default.
- W4311764520 hasConcept C2776694085 @default.
- W4311764520 hasConcept C2776999253 @default.
- W4311764520 hasConcept C2777292972 @default.
- W4311764520 hasConcept C2779013556 @default.
- W4311764520 hasConcept C2781323092 @default.
- W4311764520 hasConcept C502942594 @default.
- W4311764520 hasConcept C71924100 @default.
- W4311764520 hasConcept C86803240 @default.
- W4311764520 hasConcept C98274493 @default.
- W4311764520 hasConceptScore W4311764520C121608353 @default.
- W4311764520 hasConceptScore W4311764520C126322002 @default.
- W4311764520 hasConceptScore W4311764520C15083742 @default.
- W4311764520 hasConceptScore W4311764520C150903083 @default.
- W4311764520 hasConceptScore W4311764520C155672457 @default.
- W4311764520 hasConceptScore W4311764520C171250308 @default.
- W4311764520 hasConceptScore W4311764520C178790620 @default.
- W4311764520 hasConceptScore W4311764520C185592680 @default.
- W4311764520 hasConceptScore W4311764520C192562407 @default.
- W4311764520 hasConceptScore W4311764520C207001950 @default.
- W4311764520 hasConceptScore W4311764520C2776694085 @default.
- W4311764520 hasConceptScore W4311764520C2776999253 @default.
- W4311764520 hasConceptScore W4311764520C2777292972 @default.
- W4311764520 hasConceptScore W4311764520C2779013556 @default.
- W4311764520 hasConceptScore W4311764520C2781323092 @default.