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- W4311764543 abstract "Currently, cancer ranks as the second leading cause of death worldwide, and at the same time, the burden of cancer continues to increase. The underlying molecular pathways involved in the initiation and development of cancer are the subject of considerable research worldwide. Further understanding of these pathways may lead to new cancer treatments. Growing data suggest that Tribble's homolog 3 (TRIB3) is essential in oncogenesis in many types of cancer. The mammalian tribbles family's proteins regulate various cellular and physiological functions, such as the cell cycle, stress response, signal transduction, propagation, development, differentiation, immunity, inflammatory processes, and metabolism. To exert their activities, Tribbles proteins must alter key signaling pathways, including the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3 kinase (PI3K)/AKT pathways. Recent evidence supports that TRIB3 dysregulation has been linked to various diseases, including tumor development and chemoresistance. It has been speculated that TRIB3 may either promote or inhibit the onset and development of cancer. However, it is still unclear how TRIB3 performs this dual function in cancer. In this review, we present and discuss the most recent data on the role of TRIB3 in cancer pathophysiology and chemoresistance. Furthermore, we describe in detail the molecular mechanism TRIB3 regulates in cancer." @default.
- W4311764543 created "2022-12-28" @default.
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- W4311764543 date "2023-01-01" @default.
- W4311764543 modified "2023-09-29" @default.
- W4311764543 title "The functions and molecular mechanisms of Tribbles homolog 3 (TRIB3) implicated in the pathophysiology of cancer" @default.
- W4311764543 cites W1458331036 @default.
- W4311764543 cites W1480785638 @default.
- W4311764543 cites W1481314844 @default.
- W4311764543 cites W1490956705 @default.
- W4311764543 cites W1516501920 @default.
- W4311764543 cites W1534160952 @default.
- W4311764543 cites W1591533704 @default.
- W4311764543 cites W1651776210 @default.
- W4311764543 cites W1747816738 @default.
- W4311764543 cites W1757407923 @default.
- W4311764543 cites W1822129302 @default.
- W4311764543 cites W1864729394 @default.
- W4311764543 cites W1923724713 @default.
- W4311764543 cites W1960908597 @default.
- W4311764543 cites W1964460778 @default.
- W4311764543 cites W1966975625 @default.
- W4311764543 cites W1968486675 @default.
- W4311764543 cites W1974993526 @default.
- W4311764543 cites W1976047739 @default.
- W4311764543 cites W1977452730 @default.
- W4311764543 cites W1980471295 @default.
- W4311764543 cites W1984485637 @default.
- W4311764543 cites W1985453548 @default.
- W4311764543 cites W1988575331 @default.
- W4311764543 cites W1988588903 @default.
- W4311764543 cites W1990720544 @default.
- W4311764543 cites W1991642946 @default.
- W4311764543 cites W1993987570 @default.
- W4311764543 cites W1996405087 @default.
- W4311764543 cites W1996749709 @default.
- W4311764543 cites W1998166655 @default.
- W4311764543 cites W1998217509 @default.
- W4311764543 cites W1998664010 @default.
- W4311764543 cites W2003291148 @default.
- W4311764543 cites W2004125175 @default.
- W4311764543 cites W2004810143 @default.
- W4311764543 cites W2006778876 @default.
- W4311764543 cites W2007115502 @default.
- W4311764543 cites W2007857578 @default.
- W4311764543 cites W2009598346 @default.
- W4311764543 cites W2012507368 @default.
- W4311764543 cites W2013559520 @default.
- W4311764543 cites W2013966205 @default.
- W4311764543 cites W2017369330 @default.
- W4311764543 cites W2019771009 @default.
- W4311764543 cites W2024683587 @default.
- W4311764543 cites W2025064480 @default.
- W4311764543 cites W2026493214 @default.
- W4311764543 cites W2026691651 @default.
- W4311764543 cites W2028339433 @default.
- W4311764543 cites W2028376685 @default.
- W4311764543 cites W2029187086 @default.
- W4311764543 cites W2029653702 @default.
- W4311764543 cites W2030205108 @default.
- W4311764543 cites W2030617924 @default.
- W4311764543 cites W2031359784 @default.
- W4311764543 cites W2036353825 @default.
- W4311764543 cites W2037100826 @default.
- W4311764543 cites W2039031880 @default.
- W4311764543 cites W2040255749 @default.
- W4311764543 cites W2041098455 @default.
- W4311764543 cites W2042256057 @default.
- W4311764543 cites W2045031715 @default.
- W4311764543 cites W2045326722 @default.
- W4311764543 cites W2045348536 @default.
- W4311764543 cites W2046481308 @default.
- W4311764543 cites W2057274775 @default.
- W4311764543 cites W2058237671 @default.
- W4311764543 cites W2062765055 @default.
- W4311764543 cites W2063767155 @default.
- W4311764543 cites W2070300060 @default.
- W4311764543 cites W2071943997 @default.
- W4311764543 cites W2073283919 @default.
- W4311764543 cites W2073686472 @default.
- W4311764543 cites W2075026880 @default.
- W4311764543 cites W2075162479 @default.
- W4311764543 cites W2075711878 @default.
- W4311764543 cites W2077312273 @default.
- W4311764543 cites W2080100430 @default.
- W4311764543 cites W2082761274 @default.
- W4311764543 cites W2083235235 @default.