FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311771192> ?p ?o ?g. }

• W4311771192 endingPage "106344" @default.
• W4311771192 startingPage "106344" @default.
• W4311771192 abstract "Gefitinib is the first-line treatment for non-small cell lung cancer (NSCLC) harboring EGFR sensitive mutation. However, acquired resistance significantly limits its therapeutic efficacy. CircSETD3 has been reported to promote gefitinib resistance in NSCLC cells, however, its underlying mechanisms have not been fully clarified.The expression of circSETD3 were detected in NSCLC patients who received gefitinib as first-line treatment, including 20 gefitinib-sensitive patients and 20 acquired gefitinib-resistant patients. Cell viability were examined by CCK8 assay. The mRNA and protein levels were detected by qRT-PCR and western blot. Using RNA pull-down assay followed by mass spectrometry to identified proteins that interact with circSETD3. The interaction between circSETD3 and fragile X-related protein-1 (FXR1) were further validated by RNA immunoprecipitation (RIP) and pull-down analysis. Fuorescence in situ hybridization (FISH) and immunofluorescence (IF) assays was used for the identification of sub-location of circSETD3 and FXR1 in cells. The effect of circSETD3 overexpression and knockdown on NSCLC tumor growth to gefitinib sensitivity was detected using the mouse xenograft model.CircSETD3 was significantly upregulated in gefitinib-resistant NSCLC cells, and decreased the gefitinib sensitivity in vitro and in vivo. Mechanically, circSETD3 facilitated FXR1 binding to its downstream mRNA target, epithelial cell-transforming sequence 2 (ECT2), promoting ECT2 mRNA decay, which further inhibited cellular apoptosis.CircSETD3/FXR1/ECT2 axis plays a critical role in the acquired resistance to gefitinib in NSCLC. Our results highlight the potential of circSETD3 as a biomarker and therapeutic target for NSCLC patients with acquired gefitinib resistance." @default.
• W4311771192 created "2022-12-28" @default.
• W4311771192 creator A5000978243 @default.
• W4311771192 creator A5010465278 @default.
• W4311771192 creator A5026827247 @default.
• W4311771192 creator A5031325476 @default.
• W4311771192 creator A5035703876 @default.
• W4311771192 creator A5043606025 @default.
• W4311771192 creator A5063346114 @default.
• W4311771192 creator A5087906150 @default.
• W4311771192 date "2023-01-01" @default.
• W4311771192 modified "2023-10-18" @default.
• W4311771192 title "CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway" @default.
• W4311771192 cites W1755917942 @default.
• W4311771192 cites W1990013637 @default.
• W4311771192 cites W1996113224 @default.
• W4311771192 cites W2003984225 @default.
• W4311771192 cites W2014007356 @default.
• W4311771192 cites W2045179101 @default.
• W4311771192 cites W2080389159 @default.
• W4311771192 cites W2089927164 @default.
• W4311771192 cites W2093613683 @default.
• W4311771192 cites W2112602910 @default.
• W4311771192 cites W2144602805 @default.
• W4311771192 cites W2150780222 @default.
• W4311771192 cites W2152636515 @default.
• W4311771192 cites W2154149901 @default.
• W4311771192 cites W2284415752 @default.
• W4311771192 cites W2438469844 @default.
• W4311771192 cites W2507654187 @default.
• W4311771192 cites W2578187984 @default.
• W4311771192 cites W2729569868 @default.
• W4311771192 cites W2768080158 @default.
• W4311771192 cites W2782993420 @default.
• W4311771192 cites W2810130730 @default.
• W4311771192 cites W2901075415 @default.
• W4311771192 cites W2914861971 @default.
• W4311771192 cites W2922915037 @default.
• W4311771192 cites W2923970004 @default.
• W4311771192 cites W2967043226 @default.
• W4311771192 cites W2995976087 @default.
• W4311771192 cites W3015296087 @default.
• W4311771192 cites W3044219646 @default.
• W4311771192 cites W3087300559 @default.
• W4311771192 cites W3096012700 @default.
• W4311771192 cites W3109268452 @default.
• W4311771192 cites W3117640930 @default.
• W4311771192 cites W3128646645 @default.
• W4311771192 cites W3175224822 @default.
• W4311771192 cites W3184592431 @default.
• W4311771192 cites W3186141998 @default.
• W4311771192 cites W4200074879 @default.
• W4311771192 cites W4200395722 @default.
• W4311771192 cites W4206619735 @default.
• W4311771192 cites W4214761702 @default.
• W4311771192 cites W4224137754 @default.
• W4311771192 doi "https://doi.org/10.1016/j.biocel.2022.106344" @default.
• W4311771192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36503048" @default.
• W4311771192 hasPublicationYear "2023" @default.
• W4311771192 type Work @default.
• W4311771192 citedByCount "1" @default.
• W4311771192 countsByYear W43117711922023 @default.
• W4311771192 crossrefType "journal-article" @default.
• W4311771192 hasAuthorship W4311771192A5000978243 @default.
• W4311771192 hasAuthorship W4311771192A5010465278 @default.
• W4311771192 hasAuthorship W4311771192A5026827247 @default.
• W4311771192 hasAuthorship W4311771192A5031325476 @default.
• W4311771192 hasAuthorship W4311771192A5035703876 @default.
• W4311771192 hasAuthorship W4311771192A5043606025 @default.
• W4311771192 hasAuthorship W4311771192A5063346114 @default.
• W4311771192 hasAuthorship W4311771192A5087906150 @default.
• W4311771192 hasConcept C104317684 @default.
• W4311771192 hasConcept C121608353 @default.
• W4311771192 hasConcept C127561419 @default.
• W4311771192 hasConcept C143998085 @default.
• W4311771192 hasConcept C153911025 @default.
• W4311771192 hasConcept C173396325 @default.
• W4311771192 hasConcept C22615655 @default.
• W4311771192 hasConcept C2776256026 @default.
• W4311771192 hasConcept C2776415932 @default.
• W4311771192 hasConcept C2779438470 @default.
• W4311771192 hasConcept C2780580887 @default.
• W4311771192 hasConcept C502942594 @default.
• W4311771192 hasConcept C53227056 @default.
• W4311771192 hasConcept C54009773 @default.
• W4311771192 hasConcept C54355233 @default.
• W4311771192 hasConcept C71924100 @default.
• W4311771192 hasConcept C81885089 @default.
• W4311771192 hasConcept C86803240 @default.
• W4311771192 hasConceptScore W4311771192C104317684 @default.
• W4311771192 hasConceptScore W4311771192C121608353 @default.
• W4311771192 hasConceptScore W4311771192C127561419 @default.
• W4311771192 hasConceptScore W4311771192C143998085 @default.
• W4311771192 hasConceptScore W4311771192C153911025 @default.
• W4311771192 hasConceptScore W4311771192C173396325 @default.
• W4311771192 hasConceptScore W4311771192C22615655 @default.
• W4311771192 hasConceptScore W4311771192C2776256026 @default.
• W4311771192 hasConceptScore W4311771192C2776415932 @default.

• next