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• W4311778832 endingPage "130291" @default.
• W4311778832 startingPage "130291" @default.
• W4311778832 abstract "The use of ionizing radiations in radiotherapy is an effective and very common cancer treatment after surgery. Although ionizing-radiation DNA damages are extensively investigated, little is known about their effects on the other nuclear components, since their variations when studied in whole cells can be difficult to decouple from those of the cytoplasmatic structures. The organization of nuclear components plays a functional role since they are directly involved in some of the nuclear response to chemical or physical stimuli. For this reason, studying the X-ray effects on nuclear components is a crucial step in radiobiology.We have used Atomic Force Microscopy (AFM) and micro-FTIR to examine the biomechanical and biochemical properties of hydrated fixed nuclei isolated from neuroblastoma (SH-SY5Y) cells irradiated by 2, 4, 6 and 8 Gy X-ray doses.The experimental results have shown that, already at 2 Gy irradiation dose, the nuclei exhibit not only a DNA damage, but also relevant alterations of lipid saturation, protein secondary structure arrangement and a significant decrease in nuclear stiffness, which indicate a remarkable chromatin decondensation.The present work demonstrates that a multi-technique approach, able to disclose multiple features, can be helpful to achieve a comprehensive picture of the X-ray irradiation effects of the nuclear components and distinguish them from those occurring at the level of cytoplasm." @default.
• W4311778832 created "2022-12-28" @default.
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• W4311778832 date "2023-03-01" @default.
• W4311778832 modified "2023-09-27" @default.
• W4311778832 title "X-rays induced alterations in mechanical and biochemical properties of isolated SH-SY5Y nuclei" @default.
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• W4311778832 doi "https://doi.org/10.1016/j.bbagen.2022.130291" @default.
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