FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311782357> ?p ?o ?g. }

• W4311782357 abstract "Leptomeningeal carcinomatosis (LMC) is a rare but devastating complication of advanced cancer. The reported incidence may be underestimated because of the non-specific clinical presentation and the suboptimal accuracy of the confirmation tests. Despite advances in multidisciplinary care, the prognosis for patients with LMC remains poor. Gastric cancer (GC) ranking 9th in incidence among all kinds of malignancies in Taiwan. We aimed to review our experience with LMC in GC patients at a tertiary referral center to analyze the clinical features and survival outcomes. All patients with a malignant diagnosis of cerebrospinal fluid (CSF) cytology at the National Taiwan University Hospital were reviewed from January 2002 to December 2018. The survival analysis was calculated by the Kaplan-Meier method. Univariate and multivariate Cox proportional hazards regression analysis were used to identify factors associated with survival. We identified 18 patients with a diagnosis of GC-related LMC. LMC occurred in approximately 0.45% of GC patients during this period. Nine (50%) were male, and the median age was 58.5 years old. The most frequent neurological symptom of these patients was altered mental status (72.2%), followed by headache (44.4%) and nausea/vomiting (44.4%). Intracranial hypertension was noted in 87.5% with the mean opening pressure to be 385.3 mmCSF. Intrathecal (IT) chemotherapy was administered to nine patients, principally with methotrexate alone (55.6%). Fourteen patients received CSF drainage by ventriculo-peritoneal shunt or external ventricular drainage via Ommaya reservoir for relieving intracranial hypertension. In the univariate Cox proportional hazards regression analysis, the poor ECOG performance status (>2), absence of other metastases, and absence of CSF drainage were all prognostic factors of poor survival. In conclusion, LMC was a rare manifestation of GC and was associated with an extremely poor survival when the performance status was poor at presentation. CSF drainage may have some impact on the survival duration in selected cases with LMC." @default.
• W4311782357 created "2022-12-28" @default.
• W4311782357 creator A5007223711 @default.
• W4311782357 creator A5027426130 @default.
• W4311782357 creator A5033223945 @default.
• W4311782357 creator A5042729036 @default.
• W4311782357 creator A5058880419 @default.
• W4311782357 creator A5069857164 @default.
• W4311782357 creator A5086388622 @default.
• W4311782357 date "2023-03-06" @default.
• W4311782357 modified "2023-10-11" @default.
• W4311782357 title "Cytologically proven leptomeningeal carcinomatosis in gastric cancer patients: Experience in a tertiary referral center" @default.
• W4311782357 cites W1965911653 @default.
• W4311782357 cites W1998488881 @default.
• W4311782357 cites W2012281450 @default.
• W4311782357 cites W2033803151 @default.
• W4311782357 cites W2036782547 @default.
• W4311782357 cites W2037733618 @default.
• W4311782357 cites W2041271575 @default.
• W4311782357 cites W2056224843 @default.
• W4311782357 cites W2059855054 @default.
• W4311782357 cites W2069821963 @default.
• W4311782357 cites W2070226991 @default.
• W4311782357 cites W2086884195 @default.
• W4311782357 cites W2088993386 @default.
• W4311782357 cites W2109538890 @default.
• W4311782357 cites W2113638519 @default.
• W4311782357 cites W2148109672 @default.
• W4311782357 cites W2151855555 @default.
• W4311782357 cites W2170355027 @default.
• W4311782357 cites W2521186644 @default.
• W4311782357 cites W2768584883 @default.
• W4311782357 cites W2790302443 @default.
• W4311782357 cites W4236244375 @default.
• W4311782357 cites W72265911 @default.
• W4311782357 doi "https://doi.org/10.1002/aid2.13357" @default.
• W4311782357 hasPublicationYear "2023" @default.
• W4311782357 type Work @default.
• W4311782357 citedByCount "0" @default.
• W4311782357 crossrefType "journal-article" @default.
• W4311782357 hasAuthorship W4311782357A5007223711 @default.
• W4311782357 hasAuthorship W4311782357A5027426130 @default.
• W4311782357 hasAuthorship W4311782357A5033223945 @default.
• W4311782357 hasAuthorship W4311782357A5042729036 @default.
• W4311782357 hasAuthorship W4311782357A5058880419 @default.
• W4311782357 hasAuthorship W4311782357A5069857164 @default.
• W4311782357 hasAuthorship W4311782357A5086388622 @default.
• W4311782357 hasBestOaLocation W43117823571 @default.
• W4311782357 hasConcept C120665830 @default.
• W4311782357 hasConcept C121332964 @default.
• W4311782357 hasConcept C121608353 @default.
• W4311782357 hasConcept C126322002 @default.
• W4311782357 hasConcept C141071460 @default.
• W4311782357 hasConcept C144301174 @default.
• W4311782357 hasConcept C2780580376 @default.
• W4311782357 hasConcept C2780852908 @default.
• W4311782357 hasConcept C38180746 @default.
• W4311782357 hasConcept C50382708 @default.
• W4311782357 hasConcept C61511704 @default.
• W4311782357 hasConcept C71924100 @default.
• W4311782357 hasConceptScore W4311782357C120665830 @default.
• W4311782357 hasConceptScore W4311782357C121332964 @default.
• W4311782357 hasConceptScore W4311782357C121608353 @default.
• W4311782357 hasConceptScore W4311782357C126322002 @default.
• W4311782357 hasConceptScore W4311782357C141071460 @default.
• W4311782357 hasConceptScore W4311782357C144301174 @default.
• W4311782357 hasConceptScore W4311782357C2780580376 @default.
• W4311782357 hasConceptScore W4311782357C2780852908 @default.
• W4311782357 hasConceptScore W4311782357C38180746 @default.
• W4311782357 hasConceptScore W4311782357C50382708 @default.
• W4311782357 hasConceptScore W4311782357C61511704 @default.
• W4311782357 hasConceptScore W4311782357C71924100 @default.
• W4311782357 hasLocation W43117823571 @default.
• W4311782357 hasOpenAccess W4311782357 @default.
• W4311782357 hasPrimaryLocation W43117823571 @default.
• W4311782357 hasRelatedWork W1784665386 @default.
• W4311782357 hasRelatedWork W2005921017 @default.
• W4311782357 hasRelatedWork W2015534125 @default.
• W4311782357 hasRelatedWork W2040233681 @default.
• W4311782357 hasRelatedWork W2096612642 @default.
• W4311782357 hasRelatedWork W2311539149 @default.
• W4311782357 hasRelatedWork W2359492106 @default.
• W4311782357 hasRelatedWork W2893772422 @default.
• W4311782357 hasRelatedWork W2897728121 @default.
• W4311782357 hasRelatedWork W2999040680 @default.
• W4311782357 isParatext "false" @default.
• W4311782357 isRetracted "false" @default.
• W4311782357 workType "article" @default.