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- W4311784529 endingPage "181" @default.
- W4311784529 startingPage "181" @default.
- W4311784529 abstract "New tools for cancer diagnosis are being studied since early diagnosis can be crucial for a successful treatment. In this context, the use of NMR probes constitutes an efficient method of diagnosis. In this study, we investigated the use of ciprofloxacin to indirectly label the overexpression of topoisomerase-II enzymes by changes in 19F NMR chemical shifts of ciprofloxacin. Increased topoisomerase-II expression has been associated with cancer occurrence, mainly with aggressive forms of breast cancer, thus constituting a promising molecular target for new tumor cell identifiers. Using DFT calculations, we performed a spectroscopy analysis of ciprofloxacin in different chemical environments and evaluated the solvent and enzymatic effects. Our results show that ciprofloxacin forms a stable complex with the enzyme, and the main intermolecular interactions between ciprofloxacin and human topoisomerase-IIβ are hydrogen bonds, followed by π-π stacking and electrostatic interactions. Additionally, a shift of 6.04 ppm occurs in the 19F NMR signal when ciprofloxacin interacts with the human topoisomerase-IIβ enzyme, and this parameter may be an indirect marker indicating the overexpression of these enzymes in the body." @default.
- W4311784529 created "2022-12-28" @default.
- W4311784529 creator A5004074361 @default.
- W4311784529 creator A5025614915 @default.
- W4311784529 creator A5039385963 @default.
- W4311784529 date "2022-12-07" @default.
- W4311784529 modified "2023-09-25" @default.
- W4311784529 title "Structural Parameters of the Interaction between Ciprofloxacin and Human Topoisomerase-II β Enzyme: Toward New 19F NMR Chemical Shift Probes" @default.
- W4311784529 cites W1031578623 @default.
- W4311784529 cites W1977056311 @default.
- W4311784529 cites W1993077801 @default.
- W4311784529 cites W1995299716 @default.
- W4311784529 cites W1997173539 @default.
- W4311784529 cites W2006961769 @default.
- W4311784529 cites W2011108031 @default.
- W4311784529 cites W2011215428 @default.
- W4311784529 cites W2013849397 @default.
- W4311784529 cites W2014368703 @default.
- W4311784529 cites W2015428714 @default.
- W4311784529 cites W2016865664 @default.
- W4311784529 cites W2031368566 @default.
- W4311784529 cites W2037788435 @default.
- W4311784529 cites W2054164390 @default.
- W4311784529 cites W2062941476 @default.
- W4311784529 cites W2066036121 @default.
- W4311784529 cites W2069006374 @default.
- W4311784529 cites W2069151403 @default.
- W4311784529 cites W2069799411 @default.
- W4311784529 cites W2078524843 @default.
- W4311784529 cites W2079427933 @default.
- W4311784529 cites W2080705284 @default.
- W4311784529 cites W2084301258 @default.
- W4311784529 cites W2085572439 @default.
- W4311784529 cites W2090494804 @default.
- W4311784529 cites W2112421352 @default.
- W4311784529 cites W2113149246 @default.
- W4311784529 cites W2114824589 @default.
- W4311784529 cites W2129551734 @default.
- W4311784529 cites W2130479394 @default.
- W4311784529 cites W2137005453 @default.
- W4311784529 cites W2149808586 @default.
- W4311784529 cites W2154501720 @default.
- W4311784529 cites W2159105945 @default.
- W4311784529 cites W2253239516 @default.
- W4311784529 cites W2328072679 @default.
- W4311784529 cites W2371051054 @default.
- W4311784529 cites W2444389690 @default.
- W4311784529 cites W2462461068 @default.
- W4311784529 cites W2506629934 @default.
- W4311784529 cites W2521395027 @default.
- W4311784529 cites W2561001816 @default.
- W4311784529 cites W2566677301 @default.
- W4311784529 cites W2733589273 @default.
- W4311784529 cites W2735138317 @default.
- W4311784529 cites W2735577028 @default.
- W4311784529 cites W2765613843 @default.
- W4311784529 cites W2767954326 @default.
- W4311784529 cites W2772009304 @default.
- W4311784529 cites W2793674003 @default.
- W4311784529 cites W2796938019 @default.
- W4311784529 cites W2799775155 @default.
- W4311784529 cites W2799817815 @default.
- W4311784529 cites W2804152636 @default.
- W4311784529 cites W2883704341 @default.
- W4311784529 cites W2883932299 @default.
- W4311784529 cites W2884394723 @default.
- W4311784529 cites W2886673231 @default.
- W4311784529 cites W2889646458 @default.
- W4311784529 cites W2891327450 @default.
- W4311784529 cites W2895983693 @default.
- W4311784529 cites W2901263919 @default.
- W4311784529 cites W2906784387 @default.
- W4311784529 cites W2915922642 @default.
- W4311784529 cites W2922776263 @default.
- W4311784529 cites W2944239405 @default.
- W4311784529 cites W2947124871 @default.
- W4311784529 cites W2965047448 @default.
- W4311784529 cites W2983652719 @default.
- W4311784529 cites W3023892068 @default.
- W4311784529 cites W3036892618 @default.
- W4311784529 cites W3044830147 @default.
- W4311784529 cites W3046334741 @default.
- W4311784529 cites W3049235280 @default.
- W4311784529 cites W3092180128 @default.
- W4311784529 cites W3094555664 @default.
- W4311784529 cites W3114271647 @default.
- W4311784529 cites W3124611890 @default.
- W4311784529 cites W3138720114 @default.
- W4311784529 cites W3186222806 @default.
- W4311784529 cites W3193024485 @default.
- W4311784529 cites W3198396493 @default.
- W4311784529 cites W3203120412 @default.
- W4311784529 cites W4205651769 @default.
- W4311784529 cites W4206006610 @default.
- W4311784529 cites W4225547375 @default.
- W4311784529 cites W4226116867 @default.
- W4311784529 cites W4238806222 @default.
- W4311784529 cites W4240035468 @default.