Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311784531> ?p ?o ?g. }
- W4311784531 endingPage "1489" @default.
- W4311784531 startingPage "1489" @default.
- W4311784531 abstract "Extraintestinal pathogenic Escherichia coli (ExPEC) is a pathogen that causes host extraintestinal diseases. The ST95 E. coli lineage is one of the dominant ExPEC lineages in humans and poultry. In this study, we took advantage of extensive E. coli genomes available through public open-access databases to construct a detailed understanding of the phylogeny and evolution of ST95. We used a high variability of accessory genomes to highlight the diversity and dynamic traits of ST95. Isolates from diverse hosts and geographic sources were randomly located on the phylogenetic tree, which suggested that there is no host specificity for ST95. The time-scaled phylogeny showed that ST95 is an ancient and long-lasting lineage. The virulence genes, resistance genes, and pathogenicity islands (PAIs) were characterized in ST95 pan-genomes to provide novel insights into the pathogenicity and multidrug resistance (MDR) genotypes. We found that a pool of large plasmids drives virulence and MDR. Based on the unique genes in the ST95 pan-genome, we designed a novel multiplex PCR reaction to rapidly detect ST95. Overall, our study addressed a gap in the current understanding of ST95 ExPEC genomes, with significant implications for recognizing the success and spread of ST95." @default.
- W4311784531 created "2022-12-28" @default.
- W4311784531 creator A5002237778 @default.
- W4311784531 creator A5015102287 @default.
- W4311784531 creator A5031207741 @default.
- W4311784531 creator A5039664493 @default.
- W4311784531 creator A5047512762 @default.
- W4311784531 creator A5054851687 @default.
- W4311784531 creator A5054896345 @default.
- W4311784531 creator A5059673434 @default.
- W4311784531 date "2022-12-07" @default.
- W4311784531 modified "2023-09-26" @default.
- W4311784531 title "Genomics Analysis to Identify Multiple Genetic Determinants That Drive the Global Transmission of the Pandemic ST95 Lineage of Extraintestinal Pathogenic Escherichia coli (ExPEC)" @default.
- W4311784531 cites W1706469492 @default.
- W4311784531 cites W1961504819 @default.
- W4311784531 cites W1970813100 @default.
- W4311784531 cites W2011199810 @default.
- W4311784531 cites W2020473257 @default.
- W4311784531 cites W2022014644 @default.
- W4311784531 cites W2024481000 @default.
- W4311784531 cites W2027836512 @default.
- W4311784531 cites W2027999285 @default.
- W4311784531 cites W2030784696 @default.
- W4311784531 cites W2032499375 @default.
- W4311784531 cites W2063855776 @default.
- W4311784531 cites W2073322464 @default.
- W4311784531 cites W2076247828 @default.
- W4311784531 cites W2079742452 @default.
- W4311784531 cites W2080681701 @default.
- W4311784531 cites W2094448747 @default.
- W4311784531 cites W2097005840 @default.
- W4311784531 cites W2099118339 @default.
- W4311784531 cites W2103353800 @default.
- W4311784531 cites W2103933341 @default.
- W4311784531 cites W2116617401 @default.
- W4311784531 cites W2120647897 @default.
- W4311784531 cites W2122673596 @default.
- W4311784531 cites W2124351063 @default.
- W4311784531 cites W2130010389 @default.
- W4311784531 cites W2130362098 @default.
- W4311784531 cites W2133859270 @default.
- W4311784531 cites W2134852597 @default.
- W4311784531 cites W2136125842 @default.
- W4311784531 cites W2139852129 @default.
- W4311784531 cites W2141052558 @default.
- W4311784531 cites W2143325926 @default.
- W4311784531 cites W2149565822 @default.
- W4311784531 cites W2151183612 @default.
- W4311784531 cites W2151279007 @default.
- W4311784531 cites W2153148571 @default.
- W4311784531 cites W2158494127 @default.
- W4311784531 cites W2158921730 @default.
- W4311784531 cites W2160356586 @default.
- W4311784531 cites W2161299179 @default.
- W4311784531 cites W2162039208 @default.
- W4311784531 cites W2170436176 @default.
- W4311784531 cites W2265580406 @default.
- W4311784531 cites W2311395181 @default.
- W4311784531 cites W2372283948 @default.
- W4311784531 cites W2520054452 @default.
- W4311784531 cites W2573868677 @default.
- W4311784531 cites W2577444167 @default.
- W4311784531 cites W2605009741 @default.
- W4311784531 cites W2618257019 @default.
- W4311784531 cites W2622659147 @default.
- W4311784531 cites W2624546196 @default.
- W4311784531 cites W2735197607 @default.
- W4311784531 cites W2735290463 @default.
- W4311784531 cites W2794070260 @default.
- W4311784531 cites W2801159594 @default.
- W4311784531 cites W2897764724 @default.
- W4311784531 cites W2910035050 @default.
- W4311784531 cites W2944064454 @default.
- W4311784531 cites W2950524801 @default.
- W4311784531 cites W2950659867 @default.
- W4311784531 cites W2968322804 @default.
- W4311784531 cites W3010344242 @default.
- W4311784531 cites W3046211486 @default.
- W4311784531 cites W3122638194 @default.
- W4311784531 cites W4236269603 @default.
- W4311784531 cites W4292438825 @default.
- W4311784531 doi "https://doi.org/10.3390/pathogens11121489" @default.
- W4311784531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36558824" @default.
- W4311784531 hasPublicationYear "2022" @default.
- W4311784531 type Work @default.
- W4311784531 citedByCount "1" @default.
- W4311784531 countsByYear W43117845312023 @default.
- W4311784531 crossrefType "journal-article" @default.
- W4311784531 hasAuthorship W4311784531A5002237778 @default.
- W4311784531 hasAuthorship W4311784531A5015102287 @default.
- W4311784531 hasAuthorship W4311784531A5031207741 @default.
- W4311784531 hasAuthorship W4311784531A5039664493 @default.
- W4311784531 hasAuthorship W4311784531A5047512762 @default.
- W4311784531 hasAuthorship W4311784531A5054851687 @default.
- W4311784531 hasAuthorship W4311784531A5054896345 @default.
- W4311784531 hasAuthorship W4311784531A5059673434 @default.
- W4311784531 hasBestOaLocation W43117845311 @default.
- W4311784531 hasConcept C104317684 @default.