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• W4311791451 endingPage "1822" @default.
• W4311791451 startingPage "1822" @default.
• W4311791451 abstract "Alzheimer's disease (AD), which is characterized by extracellular accumulation of amyloid-beta peptide and intracellular aggregation of hyperphosphorylated tau, is the most common form of dementia. Memory loss, cognitive decline and disorientation are the ultimate consequences of neuronal death, synapse loss and neuroinflammation in AD. In general, there are many brain regions affected but neuronal loss in the locus coeruleus (LC) is one of the earliest indicators of neurodegeneration in AD. Since the LC is the main source of noradrenaline (NA) in the brain, degeneration of the LC in AD leads to decreased NA levels, causing increased neuroinflammation, enhanced amyloid and tau burden, decreased phagocytosis and impairment in cognition and long-term synaptic plasticity. In this review, we summarized current findings on the locus coeruleus-noradrenaline system and consequences of its dysfunction which is now recognized as an important contributor to AD progression." @default.
• W4311791451 created "2022-12-28" @default.
• W4311791451 creator A5078440867 @default.
• W4311791451 creator A5086008614 @default.
• W4311791451 date "2022-12-14" @default.
• W4311791451 modified "2023-09-30" @default.
• W4311791451 title "The Contribution of the Locus Coeruleus–Noradrenaline System Degeneration during the Progression of Alzheimer’s Disease" @default.
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