FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311791767> ?p ?o ?g. }

• W4311791767 abstract "T helper 1 cells (Th1 cells) and T helper 17 cells (Th17 cells) play pivotal roles in the pathogenesis of various autoimmune diseases, including psoriasis and inflammatory bowel disease (IBD). Signal transducer and activator of transcription 1 (STAT1) regulates the Th1 and Th17 cell lineage commitment at an early stage and maintains their immunological functions in vitro and in vivo. The previous strategies to block STAT1 functions to treat autoimmune diseases inhibit Th1 cell activity but simultaneously cause hyper-activation of Th17 cells. Herein, to modulate the functions of pathogenic Th1 and Th17 cells without genetic modification in normal physiological conditions, we generated the nucleus-deliverable form of the transcription modulation domain of STAT1 (ndSTAT1-TMD), which can be transduced into the nucleus of the target cells in a dose- and time-dependent manner without affecting the cell viability and T cell activation signaling events. ndSTAT1-TMD significantly blocked the differentiation of naïve CD4+ T cells into Th1 or Th17 cells via competitive inhibition of endogenous STAT1-mediated transcription, which did not influence Th2 and Treg cell differentiation. When the gene expression profile of Th1 or Th17 cells after ndSTAT1-TMD treatment was analyzed by mRNA sequencing, the expression of the genes involved in the differentiation capacity and the immunological functions of Th1 or Th17 cells were substantially reduced. The therapeutic potential of ndSTAT1-TMD was tested in the animal model of psoriasis and colitis, whose pathogenesis is mainly contributed by Th1 or/and Th17 cells. The symptoms and progression of psoriasis and colitis were significantly alleviated by ndSTAT1-TMD treatment, comparable to anti-IL-17A antibody treatment. In conclusion, our study demonstrates that ndSTAT1-TMD can be a new therapeutic reagent for Th1/17 cell-mediated autoimmune diseases by modulating the functions of pathogenic Th1 and Th17 cells together." @default.
• W4311791767 created "2022-12-28" @default.
• W4311791767 creator A5012624851 @default.
• W4311791767 creator A5026763303 @default.
• W4311791767 creator A5045815542 @default.
• W4311791767 creator A5052808731 @default.
• W4311791767 creator A5057333788 @default.
• W4311791767 creator A5080272277 @default.
• W4311791767 creator A5091261559 @default.
• W4311791767 date "2022-12-15" @default.
• W4311791767 modified "2023-10-17" @default.
• W4311791767 title "Transcriptional inhibition of STAT1 functions in the nucleus alleviates Th1 and Th17 cell-mediated inflammatory diseases" @default.
• W4311791767 cites W1939997832 @default.
• W4311791767 cites W1965785931 @default.
• W4311791767 cites W1969127506 @default.
• W4311791767 cites W1973603971 @default.
• W4311791767 cites W1975569542 @default.
• W4311791767 cites W1986081926 @default.
• W4311791767 cites W1986370046 @default.
• W4311791767 cites W1987784314 @default.
• W4311791767 cites W1991658642 @default.
• W4311791767 cites W1997985184 @default.
• W4311791767 cites W2013015134 @default.
• W4311791767 cites W2013187177 @default.
• W4311791767 cites W2015619258 @default.
• W4311791767 cites W2024346860 @default.
• W4311791767 cites W2028283753 @default.
• W4311791767 cites W2052550272 @default.
• W4311791767 cites W2054254705 @default.
• W4311791767 cites W2057096661 @default.
• W4311791767 cites W2073022365 @default.
• W4311791767 cites W2074644098 @default.
• W4311791767 cites W2088429799 @default.
• W4311791767 cites W2092345398 @default.
• W4311791767 cites W2093811773 @default.
• W4311791767 cites W2099132542 @default.
• W4311791767 cites W2137368119 @default.
• W4311791767 cites W2151910118 @default.
• W4311791767 cites W2155627613 @default.
• W4311791767 cites W2166282414 @default.
• W4311791767 cites W2170886637 @default.
• W4311791767 cites W2214074259 @default.
• W4311791767 cites W2225160522 @default.
• W4311791767 cites W2498179686 @default.
• W4311791767 cites W2562944381 @default.
• W4311791767 cites W2757949543 @default.
• W4311791767 cites W2787845701 @default.
• W4311791767 cites W2806315338 @default.
• W4311791767 cites W2811171873 @default.
• W4311791767 cites W2841059593 @default.
• W4311791767 cites W2887422108 @default.
• W4311791767 cites W2910021187 @default.
• W4311791767 cites W2919011602 @default.
• W4311791767 cites W2948320314 @default.
• W4311791767 cites W3012147355 @default.
• W4311791767 cites W3012307090 @default.
• W4311791767 cites W3041830057 @default.
• W4311791767 cites W3080367034 @default.
• W4311791767 cites W3089832126 @default.
• W4311791767 cites W3091087254 @default.
• W4311791767 cites W3122557039 @default.
• W4311791767 cites W3175465509 @default.
• W4311791767 cites W3194426002 @default.
• W4311791767 cites W4200128258 @default.
• W4311791767 cites W4241203133 @default.
• W4311791767 doi "https://doi.org/10.3389/fimmu.2022.1054472" @default.
• W4311791767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36591260" @default.
• W4311791767 hasPublicationYear "2022" @default.
• W4311791767 type Work @default.
• W4311791767 citedByCount "5" @default.
• W4311791767 countsByYear W43117917672023 @default.
• W4311791767 crossrefType "journal-article" @default.
• W4311791767 hasAuthorship W4311791767A5012624851 @default.
• W4311791767 hasAuthorship W4311791767A5026763303 @default.
• W4311791767 hasAuthorship W4311791767A5045815542 @default.
• W4311791767 hasAuthorship W4311791767A5052808731 @default.
• W4311791767 hasAuthorship W4311791767A5057333788 @default.
• W4311791767 hasAuthorship W4311791767A5080272277 @default.
• W4311791767 hasAuthorship W4311791767A5091261559 @default.
• W4311791767 hasBestOaLocation W43117917671 @default.
• W4311791767 hasConcept C104317684 @default.
• W4311791767 hasConcept C145430368 @default.
• W4311791767 hasConcept C148738053 @default.
• W4311791767 hasConcept C1491633281 @default.
• W4311791767 hasConcept C171958077 @default.
• W4311791767 hasConcept C191732599 @default.
• W4311791767 hasConcept C203014093 @default.
• W4311791767 hasConcept C2777003663 @default.
• W4311791767 hasConcept C2778690821 @default.
• W4311791767 hasConcept C2778923194 @default.
• W4311791767 hasConcept C2780564577 @default.
• W4311791767 hasConcept C502942594 @default.
• W4311791767 hasConcept C54355233 @default.
• W4311791767 hasConcept C62478195 @default.
• W4311791767 hasConcept C86339819 @default.
• W4311791767 hasConcept C86803240 @default.
• W4311791767 hasConcept C95444343 @default.
• W4311791767 hasConceptScore W4311791767C104317684 @default.
• W4311791767 hasConceptScore W4311791767C145430368 @default.
• W4311791767 hasConceptScore W4311791767C148738053 @default.

• next