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- W4311792043 endingPage "1821" @default.
- W4311792043 startingPage "1821" @default.
- W4311792043 abstract "Methionine constitutes a central hub of intracellular metabolic adaptations leading to an extended longevity (maximum lifespan). The present study follows a comparative approach analyzing methionine and related metabolite and amino acid profiles using an LC-MS/MS platform in the hearts of seven mammalian species with a longevity ranging from 3.8 to 57 years. Our findings demonstrate the existence of species-specific heart phenotypes associated with high longevity characterized by: (i) low concentration of methionine and its related sulphur-containing metabolites; (ii) low amino acid pool; and (iii) low choline concentration. Our results support the existence of heart metabotypes characterized by a down-regulation in long-lived species, supporting the idea that in longevity, less is more." @default.
- W4311792043 created "2022-12-28" @default.
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- W4311792043 date "2022-12-14" @default.
- W4311792043 modified "2023-10-09" @default.
- W4311792043 title "Methionine Metabolism Is Down-Regulated in Heart of Long-Lived Mammals" @default.
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- W4311792043 doi "https://doi.org/10.3390/biology11121821" @default.
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