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- W4311792315 endingPage "6189" @default.
- W4311792315 startingPage "6189" @default.
- W4311792315 abstract "Prostate cancer-associated deaths arise from disease progression and metastasis. Metastasis to the liver is associated with the worst clinical outcomes for prostate cancer patients, and these metastatic tumors can be particularly resistant to the currently widely used chemotherapy and hormonal therapies, such as anti-androgens which block androgen synthesis or directly target the androgen receptor. The incidence of liver metastases is reportedly increasing, with a potential correlation with use of anti-androgen therapies. A key player in prostate cancer progression and therapeutic response is the microenvironment of the tumor(s). This is a dynamic and adaptive collection of cells and proteins, which impart signals and stimuli that can alter biological processes within prostate cancer cells. Investigation in the prostate primary site has demonstrated that cells of the microenvironment are also responsive to hormones and hormonal therapies. In this review, we collate information about what happens when cancer moves to the liver: the types of prostate cancer cells that metastasize there, the response of resident mesenchymal cells of the liver, and how the interactions between the cancer cells and the microenvironment may be altered by hormonal therapy." @default.
- W4311792315 created "2022-12-28" @default.
- W4311792315 creator A5024566237 @default.
- W4311792315 creator A5053097935 @default.
- W4311792315 creator A5069423381 @default.
- W4311792315 creator A5086871685 @default.
- W4311792315 date "2022-12-15" @default.
- W4311792315 modified "2023-09-27" @default.
- W4311792315 title "Liver Microenvironment Response to Prostate Cancer Metastasis and Hormonal Therapy" @default.
- W4311792315 cites W1209284060 @default.
- W4311792315 cites W1484020898 @default.
- W4311792315 cites W1491373660 @default.
- W4311792315 cites W1495945591 @default.
- W4311792315 cites W1529267387 @default.
- W4311792315 cites W1565099141 @default.
- W4311792315 cites W1588197864 @default.
- W4311792315 cites W1589305623 @default.
- W4311792315 cites W1601681275 @default.
- W4311792315 cites W1654478997 @default.
- W4311792315 cites W1766890167 @default.
- W4311792315 cites W1916924456 @default.
- W4311792315 cites W1961220543 @default.
- W4311792315 cites W1963765725 @default.
- W4311792315 cites W1966134512 @default.
- W4311792315 cites W1967497738 @default.
- W4311792315 cites W1969866157 @default.
- W4311792315 cites W1970318111 @default.
- W4311792315 cites W1972838370 @default.
- W4311792315 cites W1973979075 @default.
- W4311792315 cites W1974834539 @default.
- W4311792315 cites W1976550982 @default.
- W4311792315 cites W1980750965 @default.
- W4311792315 cites W1985727076 @default.
- W4311792315 cites W1988902108 @default.
- W4311792315 cites W1991761103 @default.
- W4311792315 cites W1994047807 @default.
- W4311792315 cites W1999742227 @default.
- W4311792315 cites W2000299716 @default.
- W4311792315 cites W2002876239 @default.
- W4311792315 cites W2003021334 @default.
- W4311792315 cites W2003985632 @default.
- W4311792315 cites W2005557095 @default.
- W4311792315 cites W2006138763 @default.
- W4311792315 cites W2013094945 @default.
- W4311792315 cites W2017403197 @default.
- W4311792315 cites W2018718014 @default.
- W4311792315 cites W2020914260 @default.
- W4311792315 cites W2021680341 @default.
- W4311792315 cites W2026648161 @default.
- W4311792315 cites W2027515382 @default.
- W4311792315 cites W2034187845 @default.
- W4311792315 cites W2034791386 @default.
- W4311792315 cites W2037557604 @default.
- W4311792315 cites W2039015433 @default.
- W4311792315 cites W2045176719 @default.
- W4311792315 cites W2048380563 @default.
- W4311792315 cites W2050739087 @default.
- W4311792315 cites W2050950623 @default.
- W4311792315 cites W2051908389 @default.
- W4311792315 cites W2055346449 @default.
- W4311792315 cites W2056952167 @default.
- W4311792315 cites W2066024733 @default.
- W4311792315 cites W2080266804 @default.
- W4311792315 cites W2083942517 @default.
- W4311792315 cites W2085311752 @default.
- W4311792315 cites W2087693130 @default.
- W4311792315 cites W2088318211 @default.
- W4311792315 cites W2090722648 @default.
- W4311792315 cites W2090772441 @default.
- W4311792315 cites W2091134364 @default.
- W4311792315 cites W2100465174 @default.
- W4311792315 cites W2115124692 @default.
- W4311792315 cites W2117733417 @default.
- W4311792315 cites W2121023961 @default.
- W4311792315 cites W2122273161 @default.
- W4311792315 cites W2125942853 @default.
- W4311792315 cites W2130933657 @default.
- W4311792315 cites W2132241298 @default.
- W4311792315 cites W2132966617 @default.
- W4311792315 cites W2139788242 @default.
- W4311792315 cites W2148643283 @default.
- W4311792315 cites W2153047557 @default.
- W4311792315 cites W2156196736 @default.
- W4311792315 cites W2156281856 @default.
- W4311792315 cites W2157230165 @default.
- W4311792315 cites W2157592394 @default.
- W4311792315 cites W2161439053 @default.
- W4311792315 cites W2165088640 @default.
- W4311792315 cites W2165611177 @default.
- W4311792315 cites W2165963682 @default.
- W4311792315 cites W2166339241 @default.
- W4311792315 cites W2166370088 @default.
- W4311792315 cites W2166918329 @default.
- W4311792315 cites W2168108459 @default.
- W4311792315 cites W2252849995 @default.
- W4311792315 cites W2296253991 @default.
- W4311792315 cites W2307793755 @default.
- W4311792315 cites W2336583997 @default.