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- W4311793863 abstract "Two compounds 1 and 2 were isolated from the culture broth of Lepista luscina. This is the first time that compound 1 was isolated from a natural source. The structure of compound 1 was identified via 1D and 2D NMR and HRESIMS data. Compounds 1 and 2 along with 8-nitrotryptanthrin (4) were evaluated for their biological activities using the A549 lung cancer cell line. As a result, 1 and 2 inhibited the expression of Axl and immune checkpoint molecules. In addition, compounds 1, 2 and 4 were tested for HIF inhibitory activity. Compound 2 demonstrated statistically significant HIF inhibitory effects on NIH3T3 cells and 1 and 2 against ARPE19 cells." @default.
- W4311793863 created "2022-12-28" @default.
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- W4311793863 date "2022-12-15" @default.
- W4311793863 modified "2023-10-14" @default.
- W4311793863 title "Axl, Immune Checkpoint Molecules and HIF Inhibitors from the Culture Broth of Lepista luscina" @default.
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- W4311793863 doi "https://doi.org/10.3390/molecules27248925" @default.
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