FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311794018> ?p ?o ?g. }

• W4311794018 abstract "Dietary supplementation with marine lipids modulates ruminant milk composition toward a healthier fatty acid profile for consumers, but it also causes milk fat depression (MFD). Because the dairy goat industry is mainly oriented toward cheese manufacturing, MFD can elicit economic losses. There is large individual variation in animal susceptibility with goats more (RESPO+) or less (RESPO-) responsive to diet-induced MFD. Thus, we used RNA-Seq to examine gene expression profiles in mammary cells to elucidate mechanisms underlying MFD in goats and individual variation in the extent of diet-induced MFD. Differentially expression analyses (DEA) and weighted gene co-expression network analysis (WGCNA) of RNA-Seq data were used to study milk somatic cell transcriptome changes in goats consuming a diet supplemented with marine lipids. There were 45 differentially expressed genes (DEGs) between control (no-MFD, before diet-induced MFD) and MFD, and 18 between RESPO+ and RESPO-. Biological processes and pathways such as RNA transcription and Chromatin modifying enzymes were downregulated in MFD compared with controls. Regarding susceptibility to diet-induced MFD, we identified the Triglyceride Biosynthesis pathway upregulated in RESPO- goats. The WGCNA approach identified 9 significant functional modules related to milk fat production and one module to the fat yield decrease in diet-induced MFD. The onset of MFD in dairy goats is influenced by the downregulation of SREBF1, other transcription factors and chromatin-modifying enzymes. A list of DEGs between RESPO+ and RESPO- goats (e.g., DBI and GPD1), and a co-related gene network linked to the decrease in milk fat (ABCD3, FABP3, and PLIN2) was uncovered. Results suggest that alterations in fatty acid transport may play an important role in determining individual variation. These candidate genes should be further investigated." @default.
• W4311794018 created "2022-12-28" @default.
• W4311794018 creator A5024892151 @default.
• W4311794018 creator A5028146288 @default.
• W4311794018 creator A5035644030 @default.
• W4311794018 creator A5054751145 @default.
• W4311794018 creator A5069584644 @default.
• W4311794018 creator A5078504589 @default.
• W4311794018 creator A5078853930 @default.
• W4311794018 date "2022-12-15" @default.
• W4311794018 modified "2023-10-18" @default.
• W4311794018 title "Elucidating genes and gene networks linked to individual susceptibility to milk fat depression in dairy goats" @default.
• W4311794018 cites W1565311713 @default.
• W4311794018 cites W1790705121 @default.
• W4311794018 cites W183563421 @default.
• W4311794018 cites W1903949561 @default.
• W4311794018 cites W1965055200 @default.
• W4311794018 cites W1966327575 @default.
• W4311794018 cites W1984653762 @default.
• W4311794018 cites W1991295161 @default.
• W4311794018 cites W1999574084 @default.
• W4311794018 cites W2035776900 @default.
• W4311794018 cites W2042868600 @default.
• W4311794018 cites W2059111866 @default.
• W4311794018 cites W2070002676 @default.
• W4311794018 cites W2078538450 @default.
• W4311794018 cites W2099987315 @default.
• W4311794018 cites W2116780778 @default.
• W4311794018 cites W2120078011 @default.
• W4311794018 cites W2124649657 @default.
• W4311794018 cites W2127174585 @default.
• W4311794018 cites W2133155330 @default.
• W4311794018 cites W2136741401 @default.
• W4311794018 cites W2138187334 @default.
• W4311794018 cites W2138486337 @default.
• W4311794018 cites W2146008235 @default.
• W4311794018 cites W2146512944 @default.
• W4311794018 cites W2146715616 @default.
• W4311794018 cites W2149846571 @default.
• W4311794018 cites W2151687823 @default.
• W4311794018 cites W2166992789 @default.
• W4311794018 cites W2169456326 @default.
• W4311794018 cites W2175084398 @default.
• W4311794018 cites W2179438025 @default.
• W4311794018 cites W2197124664 @default.
• W4311794018 cites W2266479271 @default.
• W4311794018 cites W2482891957 @default.
• W4311794018 cites W2505295000 @default.
• W4311794018 cites W2604879115 @default.
• W4311794018 cites W2727266493 @default.
• W4311794018 cites W2737660124 @default.
• W4311794018 cites W2897596171 @default.
• W4311794018 cites W2921689872 @default.
• W4311794018 cites W2964468206 @default.
• W4311794018 cites W2972435723 @default.
• W4311794018 cites W2987967574 @default.
• W4311794018 cites W3010726343 @default.
• W4311794018 cites W3015941495 @default.
• W4311794018 cites W3031495659 @default.
• W4311794018 cites W3034853486 @default.
• W4311794018 cites W3088807941 @default.
• W4311794018 cites W3132874218 @default.
• W4311794018 cites W3170719911 @default.
• W4311794018 cites W3187232565 @default.
• W4311794018 cites W3204922674 @default.
• W4311794018 cites W4232909036 @default.
• W4311794018 doi "https://doi.org/10.3389/fvets.2022.1037764" @default.
• W4311794018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36590804" @default.
• W4311794018 hasPublicationYear "2022" @default.
• W4311794018 type Work @default.
• W4311794018 citedByCount "1" @default.
• W4311794018 crossrefType "journal-article" @default.
• W4311794018 hasAuthorship W4311794018A5024892151 @default.
• W4311794018 hasAuthorship W4311794018A5028146288 @default.
• W4311794018 hasAuthorship W4311794018A5035644030 @default.
• W4311794018 hasAuthorship W4311794018A5054751145 @default.
• W4311794018 hasAuthorship W4311794018A5069584644 @default.
• W4311794018 hasAuthorship W4311794018A5078504589 @default.
• W4311794018 hasAuthorship W4311794018A5078853930 @default.
• W4311794018 hasBestOaLocation W43117940181 @default.
• W4311794018 hasConcept C104317684 @default.
• W4311794018 hasConcept C150194340 @default.
• W4311794018 hasConcept C162317418 @default.
• W4311794018 hasConcept C54355233 @default.
• W4311794018 hasConcept C83640560 @default.
• W4311794018 hasConcept C86803240 @default.
• W4311794018 hasConceptScore W4311794018C104317684 @default.
• W4311794018 hasConceptScore W4311794018C150194340 @default.
• W4311794018 hasConceptScore W4311794018C162317418 @default.
• W4311794018 hasConceptScore W4311794018C54355233 @default.
• W4311794018 hasConceptScore W4311794018C83640560 @default.
• W4311794018 hasConceptScore W4311794018C86803240 @default.
• W4311794018 hasFunder F4320335598 @default.
• W4311794018 hasLocation W43117940181 @default.
• W4311794018 hasLocation W43117940182 @default.
• W4311794018 hasLocation W43117940183 @default.
• W4311794018 hasLocation W43117940184 @default.
• W4311794018 hasLocation W43117940185 @default.
• W4311794018 hasOpenAccess W4311794018 @default.
• W4311794018 hasPrimaryLocation W43117940181 @default.

• next