Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311794927> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W4311794927 endingPage "0" @default.
- W4311794927 startingPage "0" @default.
- W4311794927 abstract "Objective: Monosodium glutamate causes oxidative stress that affects a variety of organ systems, along with the kidney. The aim of this study was to evaluate the protective role of apocynin in kidney degeneration caused by monosodium glutamate using biochemical and histological methods. Materials and Methods: Sprague-Dawley rats (n=32) were used for this study. Four experimental groups were randomly formed: the Control (Cont), Apocynin (APO), Monosodium Glutamate (MSG), and MSG+APO groups. The MSG group received oral administration of MSG (120 mg/kg) for 28 days. The MSG+APO and APO groups received apocynin (25 mg/kg) during the last 5 days of the experiment. Kidney tissue was processed for biochemical and microscopic analyses. Biochemical methods were used to examine the levels of malondialdehyde (MDA) and glutathione (GSH) in the tissue and the activities of myeloperoxidase (MPO) and superoxide dismutase (SOD). Light and electron microscopy were also used to examine for histological changes in kidney tissue. Results: The MSG group was compared with the Cont and APO groups; it was found that MDA and MPO levels were elevated, whereas GSH and SOD activity were decreased. In contrast to the Cont and APO groups, the MSG+APO group showed higher GSH levels, lower MPO activities and increased MDA levels. While apocynin treatment improved renal tissue histology, MSGinduction led to deterioration of renal morphology. Conclusion: The study revealed that MSG increased oxidative damage and renal tissue degeneration. Moreover, apocynin reduced renal damage by modulating the ratio of antioxidants to oxidants." @default.
- W4311794927 created "2022-12-28" @default.
- W4311794927 creator A5004430282 @default.
- W4311794927 creator A5010638637 @default.
- W4311794927 creator A5015903598 @default.
- W4311794927 creator A5038450398 @default.
- W4311794927 creator A5090251293 @default.
- W4311794927 date "2022-12-15" @default.
- W4311794927 modified "2023-10-14" @default.
- W4311794927 title "Effects of Apocynin against Monosodium Glutamate-Induced Oxidative Damage in Rat Kidne" @default.
- W4311794927 doi "https://doi.org/10.26650/eurjbiol.2022.1148934" @default.
- W4311794927 hasPublicationYear "2022" @default.
- W4311794927 type Work @default.
- W4311794927 citedByCount "0" @default.
- W4311794927 crossrefType "journal-article" @default.
- W4311794927 hasAuthorship W4311794927A5004430282 @default.
- W4311794927 hasAuthorship W4311794927A5010638637 @default.
- W4311794927 hasAuthorship W4311794927A5015903598 @default.
- W4311794927 hasAuthorship W4311794927A5038450398 @default.
- W4311794927 hasAuthorship W4311794927A5090251293 @default.
- W4311794927 hasConcept C126322002 @default.
- W4311794927 hasConcept C134018914 @default.
- W4311794927 hasConcept C181199279 @default.
- W4311794927 hasConcept C185592680 @default.
- W4311794927 hasConcept C203565725 @default.
- W4311794927 hasConcept C2775838275 @default.
- W4311794927 hasConcept C2776151105 @default.
- W4311794927 hasConcept C2776914184 @default.
- W4311794927 hasConcept C2776989845 @default.
- W4311794927 hasConcept C2777209548 @default.
- W4311794927 hasConcept C2778401633 @default.
- W4311794927 hasConcept C2779719074 @default.
- W4311794927 hasConcept C2780091579 @default.
- W4311794927 hasConcept C31903555 @default.
- W4311794927 hasConcept C538909803 @default.
- W4311794927 hasConcept C55493867 @default.
- W4311794927 hasConcept C71924100 @default.
- W4311794927 hasConcept C98274493 @default.
- W4311794927 hasConceptScore W4311794927C126322002 @default.
- W4311794927 hasConceptScore W4311794927C134018914 @default.
- W4311794927 hasConceptScore W4311794927C181199279 @default.
- W4311794927 hasConceptScore W4311794927C185592680 @default.
- W4311794927 hasConceptScore W4311794927C203565725 @default.
- W4311794927 hasConceptScore W4311794927C2775838275 @default.
- W4311794927 hasConceptScore W4311794927C2776151105 @default.
- W4311794927 hasConceptScore W4311794927C2776914184 @default.
- W4311794927 hasConceptScore W4311794927C2776989845 @default.
- W4311794927 hasConceptScore W4311794927C2777209548 @default.
- W4311794927 hasConceptScore W4311794927C2778401633 @default.
- W4311794927 hasConceptScore W4311794927C2779719074 @default.
- W4311794927 hasConceptScore W4311794927C2780091579 @default.
- W4311794927 hasConceptScore W4311794927C31903555 @default.
- W4311794927 hasConceptScore W4311794927C538909803 @default.
- W4311794927 hasConceptScore W4311794927C55493867 @default.
- W4311794927 hasConceptScore W4311794927C71924100 @default.
- W4311794927 hasConceptScore W4311794927C98274493 @default.
- W4311794927 hasIssue "0" @default.
- W4311794927 hasLocation W43117949271 @default.
- W4311794927 hasOpenAccess W4311794927 @default.
- W4311794927 hasPrimaryLocation W43117949271 @default.
- W4311794927 hasRelatedWork W1970047356 @default.
- W4311794927 hasRelatedWork W1979862752 @default.
- W4311794927 hasRelatedWork W2028593366 @default.
- W4311794927 hasRelatedWork W2050141250 @default.
- W4311794927 hasRelatedWork W2150928336 @default.
- W4311794927 hasRelatedWork W2372408108 @default.
- W4311794927 hasRelatedWork W2408983143 @default.
- W4311794927 hasRelatedWork W3029281002 @default.
- W4311794927 hasRelatedWork W4311794927 @default.
- W4311794927 hasRelatedWork W4365802299 @default.
- W4311794927 hasVolume "0" @default.
- W4311794927 isParatext "false" @default.
- W4311794927 isRetracted "false" @default.
- W4311794927 workType "article" @default.