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• W4311795716 abstract "Cariprazine, a D3 preferring D3/D2 partial dopamine agonist, has shown to be effective in the treatment of acute psychosis as well as other symptom domains in schizophrenia spectrum disorders. There is also evidence suggesting a specific anti-hostility effect, starting from the first week of treatment. However, the substance has not yet been evaluated in offender populations with SSD. A 48-year-old male offender patient with SSD suffered an acute exacerbation with paranoid delusions and aggressiveness towards other patients and staff members after reduction of his paliperidone dosage due to side effects. He had had multiple treatment attempts with other antipsychotic substances and now vehemently refused the recommended clozapine. However, he was willing to try cariprazine as he expected less side effects. The patient stabilized after establishing cariprazine in cross-titration with paliperidone and bridging with low-dose haloperidol to ensure the prompt effect. With this pharmacotherapeutic approach, positive symptoms as well as hostility and aggressiveness remitted. The case illustrates the potential benefit of cariprazine in acutely exacerbated schizophrenic offenders to effectively treat psychotic symptomatology while sparing typical and atypical antipsychotics and promoting compliance due to fewer expected side effects. Due to their good efficacy even regarding aggression, the authors advocate an increased use of partial dopamine agonists in difficult, long-term courses, especially in offender patients who have already undergone various frustrating therapy attempts." @default.
• W4311795716 created "2022-12-28" @default.
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• W4311795716 date "2023-06-01" @default.
• W4311795716 modified "2023-10-14" @default.
• W4311795716 title "Cariprazine in offender patient with acute psychosis and aggressive behavior: Case report" @default.
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• W4311795716 doi "https://doi.org/10.1016/j.psycr.2022.100094" @default.
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