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• W4311798435 abstract "Abstract Background Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a refractory and recurrent subtype of B-cell ALL enriched with kinase-activating rearrangements. Incomplete understanding of the heterogeneity within the tumor cells presents a major challenge for the diagnosis and therapy of Ph-like ALL. Methods Single-cell RNA sequencing (scRNA-seq) was performed on 10,273 bone marrow mononuclear cells obtained from one patient with Ph-like ALL at diagnosis and after relapse. Integrative single-cell analysis was performed on this Ph-like ALL patient and two Ph + ALL patients at diagnosis and relapse from a previous study. Results scRNA-seq analysis exhibited a comprehensive cell atlas of one Ph-like ALL patient with a novel TPR - PDGFRB fusion gene at diagnosis and relapse. Twelve heterogeneous B-cell clusters, four with strong MKI67 expression indicating highly proliferating B cells, were identified. A relapse-enriched B-cell subset associated with poor prognosis was discovered, implicating the transcriptomic evolution during disease progression. Integrative single-cell analysis was performed on Ph-like ALL and Ph + ALL patients, and revealed Ph-like specific B-cell subpopulations and common CD8 + T cells characterized by the expression of the inhibitory receptor KLRB1 . Conclusions Collectively, scRNA-seq of Ph-like ALL with a novel TPR-PDGFRB fusion gene provides valuable insights into the underlying heterogeneity associated with disease progression and offers useful information for the development of immunotherapeutic techniques in the future." @default.
• W4311798435 created "2022-12-28" @default.
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• W4311798435 date "2022-12-15" @default.
• W4311798435 modified "2023-10-13" @default.
• W4311798435 title "Single-cell heterogeneity and dynamic evolution of Ph-like acute lymphoblastic leukemia patient with novel TPR-PDGFRB fusion gene" @default.
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• W4311798435 doi "https://doi.org/10.21203/rs.3.rs-2372797/v1" @default.
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