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- W4311807805 abstract "Abstract Immunotherapy has changed the treatment landscape for multiple cancer types. In the recent decade, great progress has been made in immunotherapy, including immune checkpoint inhibitors, adoptive T-cell therapy, and cancer vaccines. ICIs work by reversing tumor-induced immunosuppression, resulting in robust activation of the immune system and lasting immune responses. Whereas, their clinical use faces several challenges, especially the low response rate in most patients. As an increasing number of studies have focused on membrane immune checkpoint protein trafficking and degradation, which interferes with response to immunotherapy, it is necessary to summarize the mechanism regulating those transmembrane domain proteins translocated into the cytoplasm and degraded via lysosome. In addition, other immune-related transmembrane domain proteins such as T-cell receptor and major histocompatibility are associated with neoantigen presentation. The endosomal-lysosomal system can also regulate TCR and neoantigen-MHC complexes on the membrane to affect the efficacy of adoptive T-cell therapy and cancer vaccines. In conclusion, we discuss the process of surface delivery, internalization, recycling, and degradation of immune checkpoint proteins, TCR, and neoantigen-MHC complexes on the endosomal-lysosomal system in biology for optimizing cancer immunotherapy." @default.
- W4311807805 created "2022-12-28" @default.
- W4311807805 creator A5000067270 @default.
- W4311807805 creator A5068926554 @default.
- W4311807805 creator A5078128649 @default.
- W4311807805 date "2022-12-17" @default.
- W4311807805 modified "2023-10-05" @default.
- W4311807805 title "Membrane protein trafficking in the anti-tumor immune response: work of endosomal-lysosomal system" @default.
- W4311807805 cites W1510281083 @default.
- W4311807805 cites W1525994514 @default.
- W4311807805 cites W1541594543 @default.
- W4311807805 cites W1574766328 @default.
- W4311807805 cites W1867861530 @default.
- W4311807805 cites W1954997335 @default.
- W4311807805 cites W1968409779 @default.
- W4311807805 cites W1968959087 @default.
- W4311807805 cites W1970654655 @default.
- W4311807805 cites W1973200579 @default.
- W4311807805 cites W1973487419 @default.
- W4311807805 cites W1983235169 @default.
- W4311807805 cites W1984288819 @default.
- W4311807805 cites W1990741894 @default.
- W4311807805 cites W1990903265 @default.
- W4311807805 cites W1991752238 @default.
- W4311807805 cites W1992249154 @default.
- W4311807805 cites W1992336474 @default.
- W4311807805 cites W1994668150 @default.
- W4311807805 cites W1998434423 @default.
- W4311807805 cites W2003127011 @default.
- W4311807805 cites W2003683256 @default.
- W4311807805 cites W2005574904 @default.
- W4311807805 cites W2007056945 @default.
- W4311807805 cites W2008602824 @default.
- W4311807805 cites W2012072132 @default.
- W4311807805 cites W2012952808 @default.
- W4311807805 cites W2015163655 @default.
- W4311807805 cites W2015929445 @default.
- W4311807805 cites W2019196882 @default.
- W4311807805 cites W2021472146 @default.
- W4311807805 cites W2023086378 @default.
- W4311807805 cites W2034602668 @default.
- W4311807805 cites W2037370520 @default.
- W4311807805 cites W2045700382 @default.
- W4311807805 cites W2047989143 @default.
- W4311807805 cites W2055060861 @default.
- W4311807805 cites W2055786440 @default.
- W4311807805 cites W2055792519 @default.
- W4311807805 cites W2058295413 @default.
- W4311807805 cites W2071544457 @default.
- W4311807805 cites W2079696222 @default.
- W4311807805 cites W2080415741 @default.
- W4311807805 cites W2085437402 @default.
- W4311807805 cites W2091686762 @default.
- W4311807805 cites W2094028293 @default.
- W4311807805 cites W2094854776 @default.
- W4311807805 cites W2097696241 @default.
- W4311807805 cites W2098950776 @default.
- W4311807805 cites W2104043925 @default.
- W4311807805 cites W2104391163 @default.
- W4311807805 cites W2105580296 @default.
- W4311807805 cites W2114356820 @default.
- W4311807805 cites W2117355105 @default.
- W4311807805 cites W2117396050 @default.
- W4311807805 cites W2124516459 @default.
- W4311807805 cites W2125938085 @default.
- W4311807805 cites W2128194054 @default.
- W4311807805 cites W2131258235 @default.
- W4311807805 cites W2132836791 @default.
- W4311807805 cites W2137960852 @default.
- W4311807805 cites W2140461742 @default.
- W4311807805 cites W2147360261 @default.
- W4311807805 cites W2148351021 @default.
- W4311807805 cites W2155464214 @default.
- W4311807805 cites W2156312157 @default.
- W4311807805 cites W2159362168 @default.
- W4311807805 cites W2161714636 @default.
- W4311807805 cites W2162451799 @default.
- W4311807805 cites W2163909866 @default.
- W4311807805 cites W2166155213 @default.
- W4311807805 cites W2167016115 @default.
- W4311807805 cites W2168548277 @default.
- W4311807805 cites W2169599832 @default.
- W4311807805 cites W2169963308 @default.
- W4311807805 cites W2258185499 @default.
- W4311807805 cites W2263759961 @default.
- W4311807805 cites W2301161050 @default.
- W4311807805 cites W2312836697 @default.
- W4311807805 cites W2334354575 @default.
- W4311807805 cites W2436945295 @default.
- W4311807805 cites W2505392698 @default.
- W4311807805 cites W2523905541 @default.
- W4311807805 cites W2530161529 @default.
- W4311807805 cites W2568848023 @default.
- W4311807805 cites W2593331663 @default.
- W4311807805 cites W2620742429 @default.
- W4311807805 cites W2707748297 @default.
- W4311807805 cites W2749553776 @default.
- W4311807805 cites W2767723643 @default.
- W4311807805 cites W2778188986 @default.
- W4311807805 cites W2787095966 @default.