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- W4311812069 abstract "Platelets are known for their indispensable role in haemostasis and thrombosis. During oxidative stress, alteration in platelet function contributes towards multiple health complications. To date, various synthesized compounds have shown antiplatelet activity however, their uses are still ambiguous as these compounds display multiple side effects. Commercially used curcumin is a mixture of curcumin, demethoxy curcumin and bisdemethoxy curcumin. Majority of the studies demonstrate the effect of crude curcumin lacking specific understanding on the effect of pure curcumin. Therefore, in this study, curcumin was purified from crude curcumin mixture and examined against oxidative stress-induced platelet apoptosis and activation. Purified curcumin restored the AAPH-induced platelet apoptotic markers like reactive oxygen species, intracellular calcium level, mitochondrial membrane potential, cardiolipin peroxidation, cytochrome c release from mitochondria to the cytosol, and phosphatidyl serine externalization. Further, it inhibited agonists-induced platelet activation and aggregation, demonstrating its antiplatelet activity. Western blot analysis confirms the protective effect of purified curcumin against oxidative stress-induced platelet apoptosis and activation via down regulation of MAPKs protein activation including ASK1, JNK, p-38. This suggests that purified curcumin could be a potential therapeutic bioactive molecule to treat oxidative stress-induced platelet activation, apoptosis, and associated complications." @default.
- W4311812069 created "2022-12-28" @default.
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- W4311812069 date "2022-12-07" @default.
- W4311812069 modified "2023-09-26" @default.
- W4311812069 title "Oxidative stress induced platelet apoptosis/activation: alleviation by purified curcumin via ASK1-JNK/p-38 pathway" @default.
- W4311812069 doi "https://doi.org/10.22541/au.167042415.57243026/v1" @default.
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