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• W4311821652 abstract "Abstract Purpose Sagittal malalignment is a risk factor for mechanical complications after surgery for adult spinal deformity (ASD). Spinal loads, modulated by sagittal alignment, may explain this relationship. The aims of this study were to investigate the relationships between: (1) postoperative changes in loads at the proximal segment and realignment, and (2) absolute postoperative loads and postoperative alignment measures. Methods A previously validated musculoskeletal model of the whole spine was applied to study a clinical sample of 205 patients with ASD. Based on clinical and radiographic data, pre-and postoperative patient-specific alignments were simulated to predict loads at the proximal segment adjacent to the spinal fusion. Results Weak-to-moderate associations were found between pre-to-postop changes in lumbar lordosis, LL ( r = − 0.23, r = − 0.43; p < 0.001), global tilt, GT ( r = 0.26, r = 0.38; p < 0.001) and the Global Alignment and Proportion score, GAP ( r = 0.26, r = 0.37; p < 0.001), and changes in compressive and shear forces at the proximal segment. GAP score parameters, thoracic kyphosis measurements and the slope of upper instrumented vertebra were associated with changes in shear. In patients with T10-pelvis fusion, moderate-to-strong associations were found between postoperative sagittal alignment measures and compressive and shear loads, with GT showing the strongest correlations ( r = 0.75, r = 0.73, p < 0.001). Conclusions Spinal loads were estimated for patient-specific full spinal alignment profiles in a large cohort of patients with ASD pre-and postoperatively. Loads on the proximal segments were greater in association with sagittal malalignment and malorientation of proximal vertebra. Future work should explore whether they provide a causative mechanism explaining the associated risk of proximal junction complications." @default.
• W4311821652 created "2022-12-29" @default.
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• W4311821652 date "2022-12-17" @default.
• W4311821652 modified "2023-10-18" @default.
• W4311821652 title "Association between sagittal alignment and loads at the adjacent segment in the fused spine: a combined clinical and musculoskeletal modeling study of 205 patients with adult spinal deformity" @default.
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• W4311821652 doi "https://doi.org/10.1007/s00586-022-07477-4" @default.
• W4311821652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36526952" @default.
• W4311821652 hasPublicationYear "2022" @default.
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