FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311840723> ?p ?o ?g. }

• W4311840723 abstract "Abstract Background Individuals who are socioeconomically disadvantaged are at increased risk for aging-related diseases and perform less well on tests of cognitive function. The Weathering Hypothesis proposes that these disparities in physical and cognitive health arise from an acceleration of biological processes of aging. Theories of how life adversity is biologically embedded identify epigenetic alterations, including DNA methylation (DNAm), as a mechanistic interface between the environment and health. Consistent with the Weathering hypothesis and theories of biological embedding, recently developed DNAm algorithms have revealed profiles reflective of more advanced aging and lower cognitive function among socioeconomically-at-risk groups. These DNAm algorithms were developed using blood-DNA, but social and behavioral science research commonly collect saliva or cheek-swab DNA. This discrepancy is a potential barrier to research to elucidate mechanisms through which socioeconomic disadvantage affects aging and cognition. We therefore tested if social gradients observed in blood-DNAm measures could be reproduced using buccal-cell DNA obtained from cheek swabs. Results We analyzed three DNAm measures of biological aging and one DNAm measure of cognitive performance, all of which showed socioeconomic gradients in previous studies: the PhenoAge and GrimAge DNAm clocks, DunedinPACE, and Epigenetic- g . We first computed blood-buccal cross-tissue correlations in n=21 adults (GEO111165). Cross-tissue correlations were low-to-moderate across ( r =.25 to r =.48). We next conducted analyses of socioeconomic gradients using buccal DNAm data from SOEP-G (n=1128, 57% female; age mean=42 yrs, SD=21.56, range 0-72). Associations of socioeconomic status with DNAm measures of aging were in the expected direction, but were smaller as compared to reports from blood DNAm datasets ( r =-.08 to r =-.13). Conclusions Our findings are consistent with the hypothesis that socioeconomic disadvantage is associated with DNAm indicators of worse physical and cognitive health. However, relatively low cross-tissue correlations and attenuated effect-sizes for socioeconomic gradients in buccal DNAm compared with reports from analysis of blood DNAm suggest that, in order to take full advantage of buccal-DNA samples, DNAm algorithms customized to buccal DNAm are needed." @default.
• W4311840723 created "2022-12-31" @default.
• W4311840723 creator A5019619685 @default.
• W4311840723 creator A5023712106 @default.
• W4311840723 creator A5030302493 @default.
• W4311840723 creator A5030354937 @default.
• W4311840723 creator A5032824352 @default.
• W4311840723 creator A5048442961 @default.
• W4311840723 creator A5052804210 @default.
• W4311840723 creator A5054917521 @default.
• W4311840723 date "2022-12-07" @default.
• W4311840723 modified "2023-10-02" @default.
• W4311840723 title "Associations of Socioeconomic Disparities With Buccal DNA-Methylation Measures Of Biological Aging" @default.
• W4311840723 cites W2013128137 @default.
• W4311840723 cites W2054059225 @default.
• W4311840723 cites W2081182312 @default.
• W4311840723 cites W2101870168 @default.
• W4311840723 cites W2126104386 @default.
• W4311840723 cites W2126525177 @default.
• W4311840723 cites W2154704794 @default.
• W4311840723 cites W2171346943 @default.
• W4311840723 cites W2258445125 @default.
• W4311840723 cites W2407182836 @default.
• W4311840723 cites W2505166506 @default.
• W4311840723 cites W2529024004 @default.
• W4311840723 cites W2786180994 @default.
• W4311840723 cites W2806514843 @default.
• W4311840723 cites W2912654909 @default.
• W4311840723 cites W2913887378 @default.
• W4311840723 cites W2949100461 @default.
• W4311840723 cites W2951545629 @default.
• W4311840723 cites W2980520436 @default.
• W4311840723 cites W2992862671 @default.
• W4311840723 cites W3011777860 @default.
• W4311840723 cites W3026126635 @default.
• W4311840723 cites W3047728892 @default.
• W4311840723 cites W3135495407 @default.
• W4311840723 cites W3136411224 @default.
• W4311840723 cites W3158806857 @default.
• W4311840723 cites W3162861464 @default.
• W4311840723 cites W3194073634 @default.
• W4311840723 cites W3212161190 @default.
• W4311840723 cites W4205380741 @default.
• W4311840723 cites W4210713911 @default.
• W4311840723 cites W4220696576 @default.
• W4311840723 cites W4285492214 @default.
• W4311840723 doi "https://doi.org/10.1101/2022.12.07.519438" @default.
• W4311840723 hasPublicationYear "2022" @default.
• W4311840723 type Work @default.
• W4311840723 citedByCount "1" @default.
• W4311840723 countsByYear W43118407232023 @default.
• W4311840723 crossrefType "posted-content" @default.
• W4311840723 hasAuthorship W4311840723A5019619685 @default.
• W4311840723 hasAuthorship W4311840723A5023712106 @default.
• W4311840723 hasAuthorship W4311840723A5030302493 @default.
• W4311840723 hasAuthorship W4311840723A5030354937 @default.
• W4311840723 hasAuthorship W4311840723A5032824352 @default.
• W4311840723 hasAuthorship W4311840723A5048442961 @default.
• W4311840723 hasAuthorship W4311840723A5052804210 @default.
• W4311840723 hasAuthorship W4311840723A5054917521 @default.
• W4311840723 hasBestOaLocation W43118407231 @default.
• W4311840723 hasConcept C104317684 @default.
• W4311840723 hasConcept C118552586 @default.
• W4311840723 hasConcept C144024400 @default.
• W4311840723 hasConcept C147077947 @default.
• W4311840723 hasConcept C149923435 @default.
• W4311840723 hasConcept C150194340 @default.
• W4311840723 hasConcept C15744967 @default.
• W4311840723 hasConcept C167871757 @default.
• W4311840723 hasConcept C169900460 @default.
• W4311840723 hasConcept C190727270 @default.
• W4311840723 hasConcept C2775921022 @default.
• W4311840723 hasConcept C2908647359 @default.
• W4311840723 hasConcept C41091548 @default.
• W4311840723 hasConcept C42407357 @default.
• W4311840723 hasConcept C54355233 @default.
• W4311840723 hasConcept C71924100 @default.
• W4311840723 hasConcept C74909509 @default.
• W4311840723 hasConcept C86803240 @default.
• W4311840723 hasConcept C99454951 @default.
• W4311840723 hasConceptScore W4311840723C104317684 @default.
• W4311840723 hasConceptScore W4311840723C118552586 @default.
• W4311840723 hasConceptScore W4311840723C144024400 @default.
• W4311840723 hasConceptScore W4311840723C147077947 @default.
• W4311840723 hasConceptScore W4311840723C149923435 @default.
• W4311840723 hasConceptScore W4311840723C150194340 @default.
• W4311840723 hasConceptScore W4311840723C15744967 @default.
• W4311840723 hasConceptScore W4311840723C167871757 @default.
• W4311840723 hasConceptScore W4311840723C169900460 @default.
• W4311840723 hasConceptScore W4311840723C190727270 @default.
• W4311840723 hasConceptScore W4311840723C2775921022 @default.
• W4311840723 hasConceptScore W4311840723C2908647359 @default.
• W4311840723 hasConceptScore W4311840723C41091548 @default.
• W4311840723 hasConceptScore W4311840723C42407357 @default.
• W4311840723 hasConceptScore W4311840723C54355233 @default.
• W4311840723 hasConceptScore W4311840723C71924100 @default.
• W4311840723 hasConceptScore W4311840723C74909509 @default.
• W4311840723 hasConceptScore W4311840723C86803240 @default.
• W4311840723 hasConceptScore W4311840723C99454951 @default.
• W4311840723 hasLocation W43118407231 @default.

• next