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- W4311842066 abstract "Abstract Interactions between coinfecting pathogens have the potential to alter the course of infection and can act as a source of phenotypic variation in susceptibility between hosts. This phenotypic variation may influence the evolution of host-pathogen interactions within host species and interfere with patterns in the outcomes of infection across host species. Here, we examine experimental coinfections of two Cripaviruses – Cricket Paralysis Virus (CrPV), and Drosophila C Virus (DCV) –across a panel of 25 Drosophila melanogaster inbred lines and 47 Drosophilidae host species. We find that interactions between these viruses alter viral loads across D. melanogaster genotypes, with a ~3 fold increase in the viral load of DCV and a ~2.5 fold decrease in CrPV in coinfection compared to single infection, but we find little evidence of a host genetic basis for these effects. Across host species, we find no evidence of systematic changes in susceptibility during coinfection, with no interaction between DCV and CrPV detected in the majority of host species. These results suggest that phenotypic variation in coinfection interactions within host species can occur independently of natural host genetic variation in susceptibility, and that patterns of susceptibility across host species to single infections can be robust to the added complexity of coinfection." @default.
- W4311842066 created "2023-01-01" @default.
- W4311842066 creator A5010626017 @default.
- W4311842066 creator A5060938344 @default.
- W4311842066 creator A5066314509 @default.
- W4311842066 creator A5068774511 @default.
- W4311842066 creator A5089064654 @default.
- W4311842066 date "2022-12-07" @default.
- W4311842066 modified "2023-10-16" @default.
- W4311842066 title "Investigating the outcomes of virus coinfection within and across host species" @default.
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