Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311847582> ?p ?o ?g. }
- W4311847582 abstract "The extracellular matrix (ECM), a complex set of fibrillar proteins and proteoglycans, supports the renal parenchyma and provides biomechanical and biochemical cues critical for spatial-temporal patterning of cell development and acquisition of specialized functions. As in vitro models progress towards biomimicry, more attention is paid to reproducing ECM-mediated stimuli. ECM’s role in in vitro models of renal function and disease used to investigate kidney injury and regeneration is discussed. Availability, affordability, and lot-to-lot consistency are the main factors determining the selection of materials to recreate ECM in vitro. While simpler components can be synthesized in vitro , others must be isolated from animal or human tissues, either as single isolated components or as complex mixtures, such as Matrigel or decellularized formulations. Synthetic polymeric materials with dynamic and instructive capacities are also being explored for cell mechanical support to overcome the issues with natural products. ECM components can be used as simple 2D coatings or complex 3D scaffolds combining natural and synthetic materials. The goal is to recreate the biochemical signals provided by glycosaminoglycans and other signaling molecules, together with the stiffness, elasticity, segmentation, and dimensionality of the original kidney tissue, to support the specialized functions of glomerular, tubular, and vascular compartments. ECM mimicking also plays a central role in recent developments aiming to reproduce renal tissue in vitro or even in therapeutical strategies to regenerate renal function. Bioprinting of renal tubules, recellularization of kidney ECM scaffolds, and development of kidney organoids are examples. Future solutions will probably combine these technologies." @default.
- W4311847582 created "2023-01-01" @default.
- W4311847582 creator A5020650531 @default.
- W4311847582 creator A5038852662 @default.
- W4311847582 creator A5067640936 @default.
- W4311847582 creator A5068703156 @default.
- W4311847582 date "2022-12-07" @default.
- W4311847582 modified "2023-09-30" @default.
- W4311847582 title "Role of extracellular matrix components and structure in new renal models in vitro" @default.
- W4311847582 cites W1599473995 @default.
- W4311847582 cites W1731768350 @default.
- W4311847582 cites W1802574002 @default.
- W4311847582 cites W1862989971 @default.
- W4311847582 cites W1912639232 @default.
- W4311847582 cites W1963963106 @default.
- W4311847582 cites W1965446404 @default.
- W4311847582 cites W1965707694 @default.
- W4311847582 cites W1966431015 @default.
- W4311847582 cites W1967540288 @default.
- W4311847582 cites W1971163936 @default.
- W4311847582 cites W1972537518 @default.
- W4311847582 cites W1977179045 @default.
- W4311847582 cites W1979478822 @default.
- W4311847582 cites W1981364695 @default.
- W4311847582 cites W1983586766 @default.
- W4311847582 cites W1984294894 @default.
- W4311847582 cites W1986340915 @default.
- W4311847582 cites W1988442935 @default.
- W4311847582 cites W1994066928 @default.
- W4311847582 cites W1997412782 @default.
- W4311847582 cites W1999155904 @default.
- W4311847582 cites W2000274930 @default.
- W4311847582 cites W2004895836 @default.
- W4311847582 cites W2008434851 @default.
- W4311847582 cites W2009948849 @default.
- W4311847582 cites W2010088518 @default.
- W4311847582 cites W2011033546 @default.
- W4311847582 cites W2013680209 @default.
- W4311847582 cites W2018469888 @default.
- W4311847582 cites W2020399602 @default.
- W4311847582 cites W2022422012 @default.
- W4311847582 cites W2026465123 @default.
- W4311847582 cites W2027573748 @default.
- W4311847582 cites W2033569916 @default.
- W4311847582 cites W2036164570 @default.
- W4311847582 cites W2038591291 @default.
- W4311847582 cites W2045295282 @default.
- W4311847582 cites W2052700237 @default.
- W4311847582 cites W2056229778 @default.
- W4311847582 cites W2058229406 @default.
- W4311847582 cites W2074987291 @default.
- W4311847582 cites W2075695335 @default.
- W4311847582 cites W2081302563 @default.
- W4311847582 cites W2088061290 @default.
- W4311847582 cites W2092071393 @default.
- W4311847582 cites W2092490016 @default.
- W4311847582 cites W2103565029 @default.
- W4311847582 cites W2114698242 @default.
- W4311847582 cites W2115742652 @default.
- W4311847582 cites W2125326130 @default.
- W4311847582 cites W2146921193 @default.
- W4311847582 cites W2160615561 @default.
- W4311847582 cites W2163461914 @default.
- W4311847582 cites W2168539681 @default.
- W4311847582 cites W2169832556 @default.
- W4311847582 cites W2176166968 @default.
- W4311847582 cites W2187985754 @default.
- W4311847582 cites W2192723508 @default.
- W4311847582 cites W2208526105 @default.
- W4311847582 cites W2294427682 @default.
- W4311847582 cites W2298769293 @default.
- W4311847582 cites W2330583061 @default.
- W4311847582 cites W2336452123 @default.
- W4311847582 cites W2429460165 @default.
- W4311847582 cites W2430420587 @default.
- W4311847582 cites W2465744247 @default.
- W4311847582 cites W2530360197 @default.
- W4311847582 cites W2564377385 @default.
- W4311847582 cites W2564975634 @default.
- W4311847582 cites W2578859604 @default.
- W4311847582 cites W2592729020 @default.
- W4311847582 cites W2594061930 @default.
- W4311847582 cites W2599147137 @default.
- W4311847582 cites W2616798177 @default.
- W4311847582 cites W2736162067 @default.
- W4311847582 cites W2755543626 @default.
- W4311847582 cites W2763938157 @default.
- W4311847582 cites W2767871975 @default.
- W4311847582 cites W2769418381 @default.
- W4311847582 cites W2771630260 @default.
- W4311847582 cites W2791909710 @default.
- W4311847582 cites W2793858243 @default.
- W4311847582 cites W2802405809 @default.
- W4311847582 cites W2867094291 @default.
- W4311847582 cites W2897076273 @default.
- W4311847582 cites W2899098466 @default.
- W4311847582 cites W2903334041 @default.
- W4311847582 cites W2904971642 @default.
- W4311847582 cites W2907545141 @default.
- W4311847582 cites W2912021608 @default.