FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311847764> ?p ?o ?g. }

• W4311847764 abstract "Background There is little evidence of the effectiveness of switching from the endothelin receptor antagonists (ERAs) bosentan and ambrisentan to a novel ERA, macitentan, in patients with pulmonary arterial hypertension (PAH). Therefore, a systematic review and meta-analysis was performed to evaluate the efficacy and safety of patients with PAH switching from other ERAs to macitentan. Methods We retrieved the relevant literature published before January 2022 for the meta-analysis from the PubMed, EMBASE, and Cochrane Library databases. Efficacy included changes in the 6-min walk distance (6MWD), World Health Organization functional class (WHO-FC), N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, hemodynamics, echocardiography and survival. Results Nine studies, consisting of 408 PAH patients, that met the inclusion criteria were included. The switch from bosentan or ambrisentan to macitentan effectively increased the 6MWD by 20.71 m (95% CI: 10.35-31.07, P &lt; 0.00001, I 2 = 0%). Six months after conversion, the tricuspid annular plane systolic excursion was found to improve from 19.0 ± 4.0 to 21.0 ± 5.0 mm in adults and from 16.00 ± 5.0 to 18.25 ± 4.8 mm in children. Ordinal logistic regression showed that the WHO-FC significantly improved by 0.412 (95% CI: 0.187-0.908, P = 0.028). The switch did not show significant improvement in NT-proBNP levels. In addition, the switch was well tolerated. Conclusion The switch from bosentan or ambrisentan to macitentan significantly increased the 6MWD in PAH patients, improved the WHO-FC, and exerted safety benefits. The effects of the switch on NT-proBNP levels, hemodynamics, and echocardiography still need to be further confirmed. Systematic review registration [ https://www.crd.york.ac.uk/prospero/ ], identifier [CRD42021292554]." @default.
• W4311847764 created "2023-01-01" @default.
• W4311847764 creator A5004517509 @default.
• W4311847764 creator A5004888439 @default.
• W4311847764 creator A5018426593 @default.
• W4311847764 creator A5028859676 @default.
• W4311847764 creator A5037682713 @default.
• W4311847764 creator A5042673299 @default.
• W4311847764 creator A5047441348 @default.
• W4311847764 creator A5048212986 @default.
• W4311847764 creator A5062071376 @default.
• W4311847764 creator A5065037360 @default.
• W4311847764 creator A5068252474 @default.
• W4311847764 creator A5068359884 @default.
• W4311847764 creator A5069624559 @default.
• W4311847764 creator A5081121607 @default.
• W4311847764 creator A5085680442 @default.
• W4311847764 date "2022-12-07" @default.
• W4311847764 modified "2023-09-27" @default.
• W4311847764 title "Efficacy and safety of switching from bosentan or ambrisentan to macitentan in pulmonary arterial hypertension: A systematic review and meta-analysis" @default.
• W4311847764 cites W1866413456 @default.
• W4311847764 cites W1974227996 @default.
• W4311847764 cites W1977124407 @default.
• W4311847764 cites W1985895863 @default.
• W4311847764 cites W2025896576 @default.
• W4311847764 cites W2039662407 @default.
• W4311847764 cites W2048443661 @default.
• W4311847764 cites W2057857083 @default.
• W4311847764 cites W2077788923 @default.
• W4311847764 cites W2138649273 @default.
• W4311847764 cites W2140319297 @default.
• W4311847764 cites W2143132974 @default.
• W4311847764 cites W2156098321 @default.
• W4311847764 cites W2158862125 @default.
• W4311847764 cites W2171240223 @default.
• W4311847764 cites W246286872 @default.
• W4311847764 cites W2512568142 @default.
• W4311847764 cites W2531336280 @default.
• W4311847764 cites W2552146067 @default.
• W4311847764 cites W2594878748 @default.
• W4311847764 cites W2773538245 @default.
• W4311847764 cites W2798237497 @default.
• W4311847764 cites W2901628454 @default.
• W4311847764 cites W2904385559 @default.
• W4311847764 cites W2937085952 @default.
• W4311847764 cites W2978795816 @default.
• W4311847764 cites W2996845266 @default.
• W4311847764 cites W2998467255 @default.
• W4311847764 cites W3016192486 @default.
• W4311847764 cites W3018945078 @default.
• W4311847764 cites W3212536322 @default.
• W4311847764 cites W4210635558 @default.
• W4311847764 cites W4294215472 @default.
• W4311847764 doi "https://doi.org/10.3389/fcvm.2022.977110" @default.
• W4311847764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36568539" @default.
• W4311847764 hasPublicationYear "2022" @default.
• W4311847764 type Work @default.
• W4311847764 citedByCount "0" @default.
• W4311847764 crossrefType "journal-article" @default.
• W4311847764 hasAuthorship W4311847764A5004517509 @default.
• W4311847764 hasAuthorship W4311847764A5004888439 @default.
• W4311847764 hasAuthorship W4311847764A5018426593 @default.
• W4311847764 hasAuthorship W4311847764A5028859676 @default.
• W4311847764 hasAuthorship W4311847764A5037682713 @default.
• W4311847764 hasAuthorship W4311847764A5042673299 @default.
• W4311847764 hasAuthorship W4311847764A5047441348 @default.
• W4311847764 hasAuthorship W4311847764A5048212986 @default.
• W4311847764 hasAuthorship W4311847764A5062071376 @default.
• W4311847764 hasAuthorship W4311847764A5065037360 @default.
• W4311847764 hasAuthorship W4311847764A5068252474 @default.
• W4311847764 hasAuthorship W4311847764A5068359884 @default.
• W4311847764 hasAuthorship W4311847764A5069624559 @default.
• W4311847764 hasAuthorship W4311847764A5081121607 @default.
• W4311847764 hasAuthorship W4311847764A5085680442 @default.
• W4311847764 hasBestOaLocation W43118477641 @default.
• W4311847764 hasConcept C126322002 @default.
• W4311847764 hasConcept C144980905 @default.
• W4311847764 hasConcept C164705383 @default.
• W4311847764 hasConcept C170493617 @default.
• W4311847764 hasConcept C2776345702 @default.
• W4311847764 hasConcept C2776478404 @default.
• W4311847764 hasConcept C2780263000 @default.
• W4311847764 hasConcept C2780930700 @default.
• W4311847764 hasConcept C2781109936 @default.
• W4311847764 hasConcept C71924100 @default.
• W4311847764 hasConcept C95190672 @default.
• W4311847764 hasConceptScore W4311847764C126322002 @default.
• W4311847764 hasConceptScore W4311847764C144980905 @default.
• W4311847764 hasConceptScore W4311847764C164705383 @default.
• W4311847764 hasConceptScore W4311847764C170493617 @default.
• W4311847764 hasConceptScore W4311847764C2776345702 @default.
• W4311847764 hasConceptScore W4311847764C2776478404 @default.
• W4311847764 hasConceptScore W4311847764C2780263000 @default.
• W4311847764 hasConceptScore W4311847764C2780930700 @default.
• W4311847764 hasConceptScore W4311847764C2781109936 @default.
• W4311847764 hasConceptScore W4311847764C71924100 @default.
• W4311847764 hasConceptScore W4311847764C95190672 @default.
• W4311847764 hasLocation W43118477641 @default.
• W4311847764 hasLocation W43118477642 @default.
• W4311847764 hasLocation W43118477643 @default.

• next