FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311850652> ?p ?o ?g. }

• W4311850652 abstract "Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease preferentially affects the optic nerve and the spinal cord. The first attack usually occurs in the third or fourth decade, though patients with disease onset in the fifties or later are not uncommon. This study aimed to investigate the clinical characteristics and prognosis in patients with different age of onset and to explore the correlations between age of onset and clinical characteristics and prognostic outcomes.We retrospectively reviewed the medical records of 298 NMOSD patients diagnosed according to the 2015 updated version of diagnostic criteria. Patients were divided into early-onset NMOSD (EO-NMOSD) (<50 years at disease onset) and late-onset NMOSD (LO-NMOSD) (≥50 years at disease onset) based on the age of disease onset. LO-NMOSD patients were divided into two subgroups: relative-late-onset NMOSD (RLO-NMOSD) (50~70 years at disease onset) and very-late-onset NMOSD (≥70 years at disease onset). Clinical characteristics, laboratory findings, neuroimaging features, and prognostic outcomes were investigated.Compared to EO-NMOSD patients, patients with LO-NMOSD showed more frequent transverse myelitis (TM) (58.20% vs. 36.00%, p = 0.007) while less frequent optic neuritis (ON) (23.10% vs. 34.80%, p = 0.031) and brainstem/cerebral attacks (7.50% vs. 18.30%, p = 0.006) as the first attack. Patients with LO-NMOSD showed less frequent relapses, higher Expanded Disability Status Scale (EDSS) score at the last follow-up, fewer NMOSD-typical brain lesions, and longer segments of spinal cord lesions. Patients with older onset age showed a higher proportion of increased protein levels in cerebrospinal fluid during the acute phase of attacks. Age at disease onset positively correlated with length of spinal cord lesions at first attack and at last follow-up, negatively correlated with ARR-1 (ARR excluding the first attack, calculated from disease onset to final follow-up), irrespective of AQP4-IgG serostatus. Patients with older age at disease onset progressed to severe motor disability sooner, and age of onset positively correlated with EDSS score at the last follow-up, irrespective of AQP4-IgG serostatus.Age of disease onset affects clinical characteristics and prognosis outcomes of patients with NMOSD." @default.
• W4311850652 created "2023-01-01" @default.
• W4311850652 creator A5001427581 @default.
• W4311850652 creator A5010229749 @default.
• W4311850652 creator A5014684602 @default.
• W4311850652 creator A5022821909 @default.
• W4311850652 creator A5030416193 @default.
• W4311850652 creator A5037751722 @default.
• W4311850652 creator A5044396095 @default.
• W4311850652 creator A5048097226 @default.
• W4311850652 creator A5048913550 @default.
• W4311850652 creator A5056904374 @default.
• W4311850652 creator A5059148581 @default.
• W4311850652 creator A5061912127 @default.
• W4311850652 creator A5090519794 @default.
• W4311850652 date "2022-12-08" @default.
• W4311850652 modified "2023-10-18" @default.
• W4311850652 title "Age of onset correlates with clinical characteristics and prognostic outcomes in neuromyelitis optica spectrum disorder" @default.
• W4311850652 cites W1501925426 @default.
• W4311850652 cites W1926927712 @default.
• W4311850652 cites W1977920771 @default.
• W4311850652 cites W1987714137 @default.
• W4311850652 cites W2041825042 @default.
• W4311850652 cites W2082037716 @default.
• W4311850652 cites W2082957927 @default.
• W4311850652 cites W2095982496 @default.
• W4311850652 cites W2107941546 @default.
• W4311850652 cites W2112165124 @default.
• W4311850652 cites W2116461019 @default.
• W4311850652 cites W2128597204 @default.
• W4311850652 cites W2129229339 @default.
• W4311850652 cites W2130830366 @default.
• W4311850652 cites W2134211282 @default.
• W4311850652 cites W2151890979 @default.
• W4311850652 cites W2162560008 @default.
• W4311850652 cites W230955132 @default.
• W4311850652 cites W2543115764 @default.
• W4311850652 cites W2568236047 @default.
• W4311850652 cites W2606458885 @default.
• W4311850652 cites W2901819197 @default.
• W4311850652 cites W2970653686 @default.
• W4311850652 cites W2971527334 @default.
• W4311850652 cites W2974609913 @default.
• W4311850652 cites W2999095672 @default.
• W4311850652 cites W3000110601 @default.
• W4311850652 cites W3012376934 @default.
• W4311850652 cites W3017050357 @default.
• W4311850652 cites W3034091903 @default.
• W4311850652 cites W3087282011 @default.
• W4311850652 cites W3088230068 @default.
• W4311850652 cites W3127250308 @default.
• W4311850652 cites W3158671350 @default.
• W4311850652 cites W3159522992 @default.
• W4311850652 cites W3214777575 @default.
• W4311850652 cites W4200232415 @default.
• W4311850652 cites W4206710086 @default.
• W4311850652 cites W4206912555 @default.
• W4311850652 cites W4224097523 @default.
• W4311850652 doi "https://doi.org/10.3389/fimmu.2022.1056944" @default.
• W4311850652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36569880" @default.
• W4311850652 hasPublicationYear "2022" @default.
• W4311850652 type Work @default.
• W4311850652 citedByCount "0" @default.
• W4311850652 crossrefType "journal-article" @default.
• W4311850652 hasAuthorship W4311850652A5001427581 @default.
• W4311850652 hasAuthorship W4311850652A5010229749 @default.
• W4311850652 hasAuthorship W4311850652A5014684602 @default.
• W4311850652 hasAuthorship W4311850652A5022821909 @default.
• W4311850652 hasAuthorship W4311850652A5030416193 @default.
• W4311850652 hasAuthorship W4311850652A5037751722 @default.
• W4311850652 hasAuthorship W4311850652A5044396095 @default.
• W4311850652 hasAuthorship W4311850652A5048097226 @default.
• W4311850652 hasAuthorship W4311850652A5048913550 @default.
• W4311850652 hasAuthorship W4311850652A5056904374 @default.
• W4311850652 hasAuthorship W4311850652A5059148581 @default.
• W4311850652 hasAuthorship W4311850652A5061912127 @default.
• W4311850652 hasAuthorship W4311850652A5090519794 @default.
• W4311850652 hasBestOaLocation W43118506521 @default.
• W4311850652 hasConcept C118552586 @default.
• W4311850652 hasConcept C126322002 @default.
• W4311850652 hasConcept C187212893 @default.
• W4311850652 hasConcept C195910791 @default.
• W4311850652 hasConcept C2776572573 @default.
• W4311850652 hasConcept C2777154362 @default.
• W4311850652 hasConcept C2777185649 @default.
• W4311850652 hasConcept C2777704947 @default.
• W4311850652 hasConcept C2777767895 @default.
• W4311850652 hasConcept C2779134260 @default.
• W4311850652 hasConcept C2780640218 @default.
• W4311850652 hasConcept C2780775167 @default.
• W4311850652 hasConcept C2781137167 @default.
• W4311850652 hasConcept C71924100 @default.
• W4311850652 hasConceptScore W4311850652C118552586 @default.
• W4311850652 hasConceptScore W4311850652C126322002 @default.
• W4311850652 hasConceptScore W4311850652C187212893 @default.
• W4311850652 hasConceptScore W4311850652C195910791 @default.
• W4311850652 hasConceptScore W4311850652C2776572573 @default.
• W4311850652 hasConceptScore W4311850652C2777154362 @default.
• W4311850652 hasConceptScore W4311850652C2777185649 @default.
• W4311850652 hasConceptScore W4311850652C2777704947 @default.

• next