Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311852521> ?p ?o ?g. }
- W4311852521 endingPage "8658" @default.
- W4311852521 startingPage "8658" @default.
- W4311852521 abstract "Background: The current study utilizes in silico molecular docking/molecular dynamics to evaluate the binding affinity of apigenin and safranal with 5HT1AR/5HT2AR, followed by assessment of in vivo effects of these compounds on depressive and anxious behavior. Methods: The docking between apigenin and safranal and the 5HT1A and 5HT2A receptors was performed utilizing AutoDock Vina software, while MD and protein-lipid molecular dynamics simulations were executed by AMBER16 software. For in vivo analysis, healthy control (HC), disease control (DC), fluoxetine-, and apigenin-safranal-treated rats were tested for changes in depression and anxiety using the forced swim test (FST) and the elevated plus-maze test (EPMT), respectively. Results: The binding affinity estimations identified the superior interacting capacity of apigenin over safranal for 5HT1A/5HT2A receptors over 200 ns MD simulations. Both compounds exhibit oral bioavailability and absorbance. In the rodent model, there was a significant increase in the overall mobility time in the FST, while in the EPMT, there was a decrease in latency and an increase in the number of entries for the treated and HC rats compared with the DC rats, suggesting a reduction in depressive/anxiety symptoms after treatment. Conclusions: Our analyses suggest apigenin and safranal as prospective medication options to treat depression and anxiety." @default.
- W4311852521 created "2023-01-01" @default.
- W4311852521 creator A5006498731 @default.
- W4311852521 creator A5017864915 @default.
- W4311852521 creator A5021174253 @default.
- W4311852521 creator A5028789314 @default.
- W4311852521 creator A5028829895 @default.
- W4311852521 creator A5040596072 @default.
- W4311852521 creator A5041190641 @default.
- W4311852521 creator A5041840701 @default.
- W4311852521 creator A5063272188 @default.
- W4311852521 creator A5073541188 @default.
- W4311852521 creator A5089504455 @default.
- W4311852521 creator A5090394036 @default.
- W4311852521 date "2022-12-07" @default.
- W4311852521 modified "2023-09-30" @default.
- W4311852521 title "Interactions of Apigenin and Safranal with the 5HT1A and 5HT2A Receptors and Behavioral Effects in Depression and Anxiety: A Molecular Docking, Lipid-Mediated Molecular Dynamics, and In Vivo Analysis" @default.
- W4311852521 cites W1549357029 @default.
- W4311852521 cites W1560035352 @default.
- W4311852521 cites W1577466609 @default.
- W4311852521 cites W165875913 @default.
- W4311852521 cites W1740740888 @default.
- W4311852521 cites W1839303432 @default.
- W4311852521 cites W1886996212 @default.
- W4311852521 cites W1963845609 @default.
- W4311852521 cites W1964362672 @default.
- W4311852521 cites W1966331775 @default.
- W4311852521 cites W1966615954 @default.
- W4311852521 cites W1976161355 @default.
- W4311852521 cites W1987972424 @default.
- W4311852521 cites W1989622995 @default.
- W4311852521 cites W1994733829 @default.
- W4311852521 cites W1995826869 @default.
- W4311852521 cites W1997224604 @default.
- W4311852521 cites W1999490251 @default.
- W4311852521 cites W2013109283 @default.
- W4311852521 cites W2013457279 @default.
- W4311852521 cites W2020184819 @default.
- W4311852521 cites W2021520922 @default.
- W4311852521 cites W2028012695 @default.
- W4311852521 cites W2028701653 @default.
- W4311852521 cites W2033495141 @default.
- W4311852521 cites W2035266068 @default.
- W4311852521 cites W2037987426 @default.
- W4311852521 cites W2041806805 @default.
- W4311852521 cites W2044390612 @default.
- W4311852521 cites W2048622861 @default.
- W4311852521 cites W2052110860 @default.
- W4311852521 cites W2058120274 @default.
- W4311852521 cites W2064070148 @default.
- W4311852521 cites W2067174909 @default.
- W4311852521 cites W2067751371 @default.
- W4311852521 cites W2068417564 @default.
- W4311852521 cites W2068497137 @default.
- W4311852521 cites W2073653054 @default.
- W4311852521 cites W2074457753 @default.
- W4311852521 cites W2103945336 @default.
- W4311852521 cites W2105668062 @default.
- W4311852521 cites W2113347752 @default.
- W4311852521 cites W2114520383 @default.
- W4311852521 cites W2114650590 @default.
- W4311852521 cites W2117458899 @default.
- W4311852521 cites W2124291611 @default.
- W4311852521 cites W2132324173 @default.
- W4311852521 cites W2134967712 @default.
- W4311852521 cites W2147993766 @default.
- W4311852521 cites W2161450017 @default.
- W4311852521 cites W2164270482 @default.
- W4311852521 cites W2169678694 @default.
- W4311852521 cites W2175540148 @default.
- W4311852521 cites W2177317049 @default.
- W4311852521 cites W2197078876 @default.
- W4311852521 cites W2274762642 @default.
- W4311852521 cites W2283292195 @default.
- W4311852521 cites W2336040088 @default.
- W4311852521 cites W2404280981 @default.
- W4311852521 cites W2520075163 @default.
- W4311852521 cites W2553251493 @default.
- W4311852521 cites W2571773383 @default.
- W4311852521 cites W2589770645 @default.
- W4311852521 cites W2737422549 @default.
- W4311852521 cites W2753654430 @default.
- W4311852521 cites W2758858256 @default.
- W4311852521 cites W2762586253 @default.
- W4311852521 cites W2765790877 @default.
- W4311852521 cites W2781803189 @default.
- W4311852521 cites W2795525894 @default.
- W4311852521 cites W2805062243 @default.
- W4311852521 cites W2888290218 @default.
- W4311852521 cites W2890622342 @default.
- W4311852521 cites W2900825389 @default.
- W4311852521 cites W2911542458 @default.
- W4311852521 cites W2914147912 @default.
- W4311852521 cites W2921026906 @default.
- W4311852521 cites W2967342569 @default.
- W4311852521 cites W2981767691 @default.
- W4311852521 cites W2986889442 @default.
- W4311852521 cites W2990455503 @default.