FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311852678> ?p ?o ?g. }

• W4311852678 endingPage "2309" @default.
• W4311852678 startingPage "2309" @default.
• W4311852678 abstract "Pulmonary neuroendocrine neoplasms (PNENs) are currently classified into four major histotypes, including typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC), and small cell lung carcinoma (SCLC). This classification was designed to be applied to surgical specimens mostly anchored in morphological parameters, resulting in considerable overlapping among PNENs, which may result in important challenges for clinicians’ decisions in the case of small biopsies. Since PNENs originate from the neuroectodermic cells, epithelial-to-mesenchymal transition (EMT) gene expression shows promise as biomarkers involved in the genotypic transformation of neuroectodermic cells, including mutation burden with the involvement of chromatin remodeling genes, apoptosis, and mitosis rate, leading to modification in final cellular phenotype. In this situation, additional markers also applicable to biopsy specimens, which correlate PNENs subtypes with systemic treatment response, are much needed, and current potential candidates are neurogenic EMT genes. This study investigated EMT genes expression and its association with PNENs histotypes in tumor tissues from 24 patients with PNENs. PCR Array System for 84 EMT-related genes selected 15 differentially expressed genes among the PNENs, allowing to discriminate TC from AC, LCNEC from AC, and SCLC from AC. Functional enrichment analysis of the EMT genes differentially expressed among PNENs subtypes showed that they are involved in cellular proliferation, extracellular matrix degradation, regulation of cell apoptosis, oncogenesis, and tumor cell invasion. Interestingly, four EMT genes (MAP1B, SNAI2, MMP2, WNT5A) are also involved in neurological diseases, in brain metastasis, and interact with platinum-based chemotherapy and tyrosine–kinase inhibitors. Collectively, these findings emerge as an important ancillary tool to improve the strategies of histologic diagnosis in PNENs and unveil the four EMT genes that can play an important role in driving chemical response in PNENs." @default.
• W4311852678 created "2023-01-01" @default.
• W4311852678 creator A5041225203 @default.
• W4311852678 creator A5048212818 @default.
• W4311852678 creator A5059076123 @default.
• W4311852678 creator A5065272990 @default.
• W4311852678 creator A5067843548 @default.
• W4311852678 creator A5073960544 @default.
• W4311852678 creator A5079456845 @default.
• W4311852678 creator A5087718065 @default.
• W4311852678 date "2022-12-07" @default.
• W4311852678 modified "2023-10-01" @default.
• W4311852678 title "Proposing Specific Neuronal Epithelial-to-Mesenchymal Transition Genes as an Ancillary Tool for Differential Diagnosis among Pulmonary Neuroendocrine Neoplasms" @default.
• W4311852678 cites W1964081206 @default.
• W4311852678 cites W1965416393 @default.
• W4311852678 cites W1969709966 @default.
• W4311852678 cites W1994231692 @default.
• W4311852678 cites W2006525401 @default.
• W4311852678 cites W2007917102 @default.
• W4311852678 cites W2010619056 @default.
• W4311852678 cites W2022469979 @default.
• W4311852678 cites W2035757068 @default.
• W4311852678 cites W2042283360 @default.
• W4311852678 cites W2049135828 @default.
• W4311852678 cites W2049915173 @default.
• W4311852678 cites W2061823019 @default.
• W4311852678 cites W2062532896 @default.
• W4311852678 cites W2066693278 @default.
• W4311852678 cites W2090914063 @default.
• W4311852678 cites W2102024523 @default.
• W4311852678 cites W2107277218 @default.
• W4311852678 cites W2109260416 @default.
• W4311852678 cites W2119907371 @default.
• W4311852678 cites W2123398154 @default.
• W4311852678 cites W2126681854 @default.
• W4311852678 cites W2149301055 @default.
• W4311852678 cites W2154589460 @default.
• W4311852678 cites W2164252602 @default.
• W4311852678 cites W2166555967 @default.
• W4311852678 cites W2192080449 @default.
• W4311852678 cites W2228221433 @default.
• W4311852678 cites W2255743805 @default.
• W4311852678 cites W2564674425 @default.
• W4311852678 cites W2568104907 @default.
• W4311852678 cites W2608160487 @default.
• W4311852678 cites W2611497676 @default.
• W4311852678 cites W2757966597 @default.
• W4311852678 cites W2763813381 @default.
• W4311852678 cites W2783999618 @default.
• W4311852678 cites W2788637603 @default.
• W4311852678 cites W2792828274 @default.
• W4311852678 cites W2799468356 @default.
• W4311852678 cites W2888018398 @default.
• W4311852678 cites W2900569176 @default.
• W4311852678 cites W2914562159 @default.
• W4311852678 cites W2916047525 @default.
• W4311852678 cites W2925662714 @default.
• W4311852678 cites W2928432651 @default.
• W4311852678 cites W2928665623 @default.
• W4311852678 cites W2980138052 @default.
• W4311852678 cites W2987617989 @default.
• W4311852678 cites W2991029237 @default.
• W4311852678 cites W2993090100 @default.
• W4311852678 cites W3021105336 @default.
• W4311852678 cites W3030771474 @default.
• W4311852678 cites W3092051613 @default.
• W4311852678 cites W3092107707 @default.
• W4311852678 cites W3126702996 @default.
• W4311852678 cites W3197880486 @default.
• W4311852678 cites W3215921195 @default.
• W4311852678 cites W4223612990 @default.
• W4311852678 cites W4226443083 @default.
• W4311852678 cites W4232078888 @default.
• W4311852678 cites W4242747250 @default.
• W4311852678 cites W4367590677 @default.
• W4311852678 cites W4376453862 @default.
• W4311852678 cites W3023111168 @default.
• W4311852678 doi "https://doi.org/10.3390/genes13122309" @default.
• W4311852678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36553576" @default.
• W4311852678 hasPublicationYear "2022" @default.
• W4311852678 type Work @default.
• W4311852678 citedByCount "0" @default.
• W4311852678 crossrefType "journal-article" @default.
• W4311852678 hasAuthorship W4311852678A5041225203 @default.
• W4311852678 hasAuthorship W4311852678A5048212818 @default.
• W4311852678 hasAuthorship W4311852678A5059076123 @default.
• W4311852678 hasAuthorship W4311852678A5065272990 @default.
• W4311852678 hasAuthorship W4311852678A5067843548 @default.
• W4311852678 hasAuthorship W4311852678A5073960544 @default.
• W4311852678 hasAuthorship W4311852678A5079456845 @default.
• W4311852678 hasAuthorship W4311852678A5087718065 @default.
• W4311852678 hasBestOaLocation W43118526781 @default.
• W4311852678 hasConcept C104317684 @default.
• W4311852678 hasConcept C121608353 @default.
• W4311852678 hasConcept C134018914 @default.
• W4311852678 hasConcept C2779013556 @default.
• W4311852678 hasConcept C2779066768 @default.
• W4311852678 hasConcept C502942594 @default.

• next