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• W4311852691 endingPage "3957" @default.
• W4311852691 startingPage "3957" @default.
• W4311852691 abstract "The challenges in making animal models of complex human epilepsy phenotypes with varied aetiology highlights the need to develop alternative disease models that can address the limitations of animal models by effectively recapitulating human pathophysiology. The advances in stem cell technology provide an opportunity to use human iPSCs to make disease-in-a-dish models. The focus of this review is to report the current information and progress in the generation of epileptic patient-specific iPSCs lines, isogenic control cell lines, and neuronal models. These in vitro models can be used to study the underlying pathological mechanisms of epilepsies, anti-seizure medication resistance, and can also be used for drug testing and drug screening with their isogenic control cell lines." @default.
• W4311852691 created "2023-01-01" @default.
• W4311852691 creator A5005944785 @default.
• W4311852691 creator A5015013868 @default.
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• W4311852691 creator A5048517148 @default.
• W4311852691 creator A5050725132 @default.
• W4311852691 creator A5067443324 @default.
• W4311852691 date "2022-12-07" @default.
• W4311852691 modified "2023-10-16" @default.
• W4311852691 title "Human In Vitro Models of Epilepsy Using Embryonic and Induced Pluripotent Stem Cells" @default.
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