Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311854913> ?p ?o ?g. }
- W4311854913 abstract "ABSTRACT Maintenance of genome integrity is essential for cell viability and depends on complete and accurate DNA replication. However, G4/R-loops may provide significant obstacles for DNA replication, as they can cause collisions between replication fork and the transcription machinery. Hence, cells require mechanisms to counteract the presence of persistent G4/R-loops, most of which remain poorly understood. Here, we demonstrate an involvement of the Werner helicase-interacting protein 1 (WRNIP1) in preventing DNA damage induced by G4/R-loop-associated transcription-replication conflicts. We discovered that the ubiquitin-binding domain of WRNIP1 is required to efficiently avoid pathological persistence of G4/R-loops upon replication stress. Also, we observed that G4s reside within R-loops and that WRNIP1 colocalises with these structures. Furthermore, WRNIP1 plays a role in restarting replication from transcription-induced fork stalling. More importantly, we characterized the interplay between WRNIP1 and the DNA helicase FANCJ in counteracting R-loop-dependent G4 formation in response to replication stress. Collectively, our findings propose a mechanisms whereby WRNIP1, contributing to stabilise FANCJ to G4 sites, mitigates the G4/R-loop-mediated transcription-replication conflicts and protects against DNA damage accumulation." @default.
- W4311854913 created "2023-01-01" @default.
- W4311854913 creator A5006069239 @default.
- W4311854913 creator A5018420071 @default.
- W4311854913 creator A5042421399 @default.
- W4311854913 creator A5051539650 @default.
- W4311854913 creator A5076795630 @default.
- W4311854913 creator A5076905892 @default.
- W4311854913 date "2022-12-18" @default.
- W4311854913 modified "2023-10-12" @default.
- W4311854913 title "WRNIP1 PREVENTS G4/R-LOOP-ASSOCIATED GENOMIC INSTABILITY" @default.
- W4311854913 cites W1549591813 @default.
- W4311854913 cites W1564224574 @default.
- W4311854913 cites W1823908009 @default.
- W4311854913 cites W1914649288 @default.
- W4311854913 cites W1967154926 @default.
- W4311854913 cites W1968789240 @default.
- W4311854913 cites W1972011626 @default.
- W4311854913 cites W1976736675 @default.
- W4311854913 cites W1982225118 @default.
- W4311854913 cites W1983127291 @default.
- W4311854913 cites W1991754576 @default.
- W4311854913 cites W2021110075 @default.
- W4311854913 cites W2021191052 @default.
- W4311854913 cites W2024222737 @default.
- W4311854913 cites W2027573386 @default.
- W4311854913 cites W2031670770 @default.
- W4311854913 cites W2035300822 @default.
- W4311854913 cites W2042374693 @default.
- W4311854913 cites W2043375872 @default.
- W4311854913 cites W2043745733 @default.
- W4311854913 cites W2057675493 @default.
- W4311854913 cites W2060121057 @default.
- W4311854913 cites W2065884484 @default.
- W4311854913 cites W2067133520 @default.
- W4311854913 cites W2078403259 @default.
- W4311854913 cites W2078411081 @default.
- W4311854913 cites W2099649920 @default.
- W4311854913 cites W2100440853 @default.
- W4311854913 cites W2103694115 @default.
- W4311854913 cites W2104301158 @default.
- W4311854913 cites W2107455041 @default.
- W4311854913 cites W2115001760 @default.
- W4311854913 cites W2118517251 @default.
- W4311854913 cites W2125700027 @default.
- W4311854913 cites W2126398144 @default.
- W4311854913 cites W2128824335 @default.
- W4311854913 cites W2136220863 @default.
- W4311854913 cites W2155773930 @default.
- W4311854913 cites W2192508404 @default.
- W4311854913 cites W2212660163 @default.
- W4311854913 cites W2275411324 @default.
- W4311854913 cites W2320692565 @default.
- W4311854913 cites W2340421620 @default.
- W4311854913 cites W2340594125 @default.
- W4311854913 cites W2409124218 @default.
- W4311854913 cites W2463453322 @default.
- W4311854913 cites W2500686989 @default.
- W4311854913 cites W2518351913 @default.
- W4311854913 cites W2582425945 @default.
- W4311854913 cites W2743954317 @default.
- W4311854913 cites W2757691983 @default.
- W4311854913 cites W2765655531 @default.
- W4311854913 cites W2784889917 @default.
- W4311854913 cites W2888533280 @default.
- W4311854913 cites W2907750653 @default.
- W4311854913 cites W2908967709 @default.
- W4311854913 cites W2909481675 @default.
- W4311854913 cites W2912993287 @default.
- W4311854913 cites W2913346540 @default.
- W4311854913 cites W2944977287 @default.
- W4311854913 cites W2952849134 @default.
- W4311854913 cites W2966334511 @default.
- W4311854913 cites W2979457360 @default.
- W4311854913 cites W2979531443 @default.
- W4311854913 cites W3005240446 @default.
- W4311854913 cites W3008572902 @default.
- W4311854913 cites W3017349264 @default.
- W4311854913 cites W3039144759 @default.
- W4311854913 cites W3047264471 @default.
- W4311854913 cites W3130338251 @default.
- W4311854913 cites W3159185663 @default.
- W4311854913 cites W3164813515 @default.
- W4311854913 cites W3199678763 @default.
- W4311854913 doi "https://doi.org/10.1101/2022.12.17.520882" @default.
- W4311854913 hasPublicationYear "2022" @default.
- W4311854913 type Work @default.
- W4311854913 citedByCount "0" @default.
- W4311854913 crossrefType "posted-content" @default.
- W4311854913 hasAuthorship W4311854913A5006069239 @default.
- W4311854913 hasAuthorship W4311854913A5018420071 @default.
- W4311854913 hasAuthorship W4311854913A5042421399 @default.
- W4311854913 hasAuthorship W4311854913A5051539650 @default.
- W4311854913 hasAuthorship W4311854913A5076795630 @default.
- W4311854913 hasAuthorship W4311854913A5076905892 @default.
- W4311854913 hasBestOaLocation W43118549131 @default.
- W4311854913 hasConcept C104317684 @default.
- W4311854913 hasConcept C104690221 @default.
- W4311854913 hasConcept C138885662 @default.
- W4311854913 hasConcept C143425029 @default.