Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311856051> ?p ?o ?g. }
- W4311856051 endingPage "2426" @default.
- W4311856051 startingPage "2426" @default.
- W4311856051 abstract "During sexual reproduction/conjugation of the ciliate Tetrahymena thermophila, the germinal micronucleus undergoes meiosis resulting in four haploid micronuclei (hMICs). All hMICs undergo post-meiotic DNA double-strand break (PM-DSB) formation, cleaving their genome. DNA lesions are subsequently repaired in only one ‘selected’ hMIC, which eventually produces gametic pronuclei. DNA repair in the selected hMIC involves chromatin remodeling by switching from the heterochromatic to the euchromatic state of its genome. Here, we demonstrate that, among the 15 Tetrahymena Snf2 family proteins, a core of the ATP-dependent chromatin remodeling complex in Tetrahymena, the germline nucleus specific Iswi in Tetrahymena IswiGTt and Rad5Tt is crucial for the generation of gametic pronuclei. In either gene knockout, the selected hMIC which shows euchromatin markers such as lysine-acetylated histone H3 does not appear, but all hMICs in which markers for DNA lesions persist are degraded, indicating that both IswiGTt and Rad5Tt have important roles in repairing PM-DSB DNA lesions and remodeling chromatin for the euchromatic state in the selected hMIC." @default.
- W4311856051 created "2023-01-01" @default.
- W4311856051 creator A5014560003 @default.
- W4311856051 creator A5017531312 @default.
- W4311856051 creator A5030565648 @default.
- W4311856051 creator A5062873438 @default.
- W4311856051 date "2022-12-07" @default.
- W4311856051 modified "2023-10-09" @default.
- W4311856051 title "Snf2 Proteins Are Required to Generate Gamete Pronuclei in Tetrahymena thermophila" @default.
- W4311856051 cites W1514415814 @default.
- W4311856051 cites W1577051069 @default.
- W4311856051 cites W1644710420 @default.
- W4311856051 cites W1979613471 @default.
- W4311856051 cites W1999011979 @default.
- W4311856051 cites W2000099078 @default.
- W4311856051 cites W2002428253 @default.
- W4311856051 cites W2004129040 @default.
- W4311856051 cites W2005377536 @default.
- W4311856051 cites W2007881673 @default.
- W4311856051 cites W2020372610 @default.
- W4311856051 cites W2025999920 @default.
- W4311856051 cites W2029214081 @default.
- W4311856051 cites W2038385761 @default.
- W4311856051 cites W2038608145 @default.
- W4311856051 cites W2038860354 @default.
- W4311856051 cites W2039502138 @default.
- W4311856051 cites W2050488981 @default.
- W4311856051 cites W2054027807 @default.
- W4311856051 cites W2055980504 @default.
- W4311856051 cites W2059854688 @default.
- W4311856051 cites W2068535893 @default.
- W4311856051 cites W2069164065 @default.
- W4311856051 cites W2074655992 @default.
- W4311856051 cites W2080890492 @default.
- W4311856051 cites W2083245183 @default.
- W4311856051 cites W2083367733 @default.
- W4311856051 cites W2089017035 @default.
- W4311856051 cites W2098460664 @default.
- W4311856051 cites W2102165823 @default.
- W4311856051 cites W2118342658 @default.
- W4311856051 cites W2118937292 @default.
- W4311856051 cites W2127774996 @default.
- W4311856051 cites W2129161084 @default.
- W4311856051 cites W2129697647 @default.
- W4311856051 cites W2135553363 @default.
- W4311856051 cites W2138215634 @default.
- W4311856051 cites W2140428119 @default.
- W4311856051 cites W2142460487 @default.
- W4311856051 cites W2145699080 @default.
- W4311856051 cites W2145929363 @default.
- W4311856051 cites W2145968307 @default.
- W4311856051 cites W2149989570 @default.
- W4311856051 cites W2151046309 @default.
- W4311856051 cites W2156821248 @default.
- W4311856051 cites W2156970346 @default.
- W4311856051 cites W2157031657 @default.
- W4311856051 cites W2159704743 @default.
- W4311856051 cites W2161520095 @default.
- W4311856051 cites W2163956111 @default.
- W4311856051 cites W2251100806 @default.
- W4311856051 cites W2419464547 @default.
- W4311856051 cites W2499618563 @default.
- W4311856051 cites W2515047160 @default.
- W4311856051 cites W2625089910 @default.
- W4311856051 cites W2735741666 @default.
- W4311856051 cites W2789841853 @default.
- W4311856051 cites W2803407896 @default.
- W4311856051 cites W2949867654 @default.
- W4311856051 cites W2990186378 @default.
- W4311856051 cites W2994758372 @default.
- W4311856051 cites W3016563974 @default.
- W4311856051 cites W3181033353 @default.
- W4311856051 cites W3186553798 @default.
- W4311856051 cites W3213664491 @default.
- W4311856051 doi "https://doi.org/10.3390/microorganisms10122426" @default.
- W4311856051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36557679" @default.
- W4311856051 hasPublicationYear "2022" @default.
- W4311856051 type Work @default.
- W4311856051 citedByCount "0" @default.
- W4311856051 crossrefType "journal-article" @default.
- W4311856051 hasAuthorship W4311856051A5014560003 @default.
- W4311856051 hasAuthorship W4311856051A5017531312 @default.
- W4311856051 hasAuthorship W4311856051A5030565648 @default.
- W4311856051 hasAuthorship W4311856051A5062873438 @default.
- W4311856051 hasBestOaLocation W43118560511 @default.
- W4311856051 hasConcept C100924687 @default.
- W4311856051 hasConcept C103435993 @default.
- W4311856051 hasConcept C104317684 @default.
- W4311856051 hasConcept C110758877 @default.
- W4311856051 hasConcept C167227067 @default.
- W4311856051 hasConcept C2777166614 @default.
- W4311856051 hasConcept C28748434 @default.
- W4311856051 hasConcept C54355233 @default.
- W4311856051 hasConcept C552990157 @default.
- W4311856051 hasConcept C56683836 @default.
- W4311856051 hasConcept C64927066 @default.
- W4311856051 hasConcept C83640560 @default.
- W4311856051 hasConcept C86803240 @default.