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- W4311856817 endingPage "1785" @default.
- W4311856817 startingPage "1785" @default.
- W4311856817 abstract "In 1981, Wylie Vale, Joachim Spiess, Catherine Rivier, and Jean Rivier reported on the characterization of a 41-amino-acid peptide from ovine hypothalamic extracts with high potency and intrinsic activity stimulating the secretion of adrenocorticotropic hormone and β-endorphin by cultured anterior pituitary cells. With its sequence known, this neuropeptide was determined to be a hormone and consequently named corticotropin-releasing hormone (CRH), although the term corticotropin-releasing factor (CRF) is still used and preferred in some circumstances. Several decades have passed since this seminal contribution that opened a new research era, expanding the understanding of the coding of stress-related processes. The characterization of CRH receptors, the availability of CRH agonists and antagonists, and advanced immunocytochemical staining techniques have provided evidence that CRH plays a role in the regulation of several biological systems. The purpose of this review is to summarize the present knowledge of this 41-amino-acid peptide." @default.
- W4311856817 created "2023-01-01" @default.
- W4311856817 creator A5002036795 @default.
- W4311856817 creator A5009749251 @default.
- W4311856817 creator A5041390788 @default.
- W4311856817 date "2022-12-08" @default.
- W4311856817 modified "2023-10-14" @default.
- W4311856817 title "Corticotropin-Releasing Hormone: Biology and Therapeutic Opportunities" @default.
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- W4311856817 doi "https://doi.org/10.3390/biology11121785" @default.