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- W4311857800 abstract "Mixed gangliocytoma-adenoma (MGA) is a rare tumor of pituitary gland. It's difficult to distinguish it from pituitary adenoma by clinical manifestations, imaging features or serological testing. Thus, the histopathological examination is still the golden standard for diagnosis. Besides, studies on molecular level are still lacking.In this case report, we described a 28-year-old male with MGA presenting as acromegaly, who suffered staging operation and post-operation gamma knife radiosurgery, but finally died of secondary hyperglycemic hyperosmolar collapse. A complete data including clinical, histopathological, ultrastructural and single-cell transcriptome level information were collected and analyzed.This case report detailed the only clinical and molecular report of MGA following operation and radiotherapy. Complete clinical data enhanced the understanding of the diagnosis and treatment of this disease. Besides, the single-cell transcriptome sequencing analysis further disclosed the intra-tumoral heterogeneity and provided support for subsequent basic research." @default.
- W4311857800 created "2023-01-01" @default.
- W4311857800 creator A5003753200 @default.
- W4311857800 creator A5043422077 @default.
- W4311857800 creator A5048814254 @default.
- W4311857800 date "2022-12-08" @default.
- W4311857800 modified "2023-09-30" @default.
- W4311857800 title "Case report: Clinical and single-cell transcriptome sequencing analysis of a mixed gangliocytoma-adenoma presenting as acromegaly" @default.
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- W4311857800 doi "https://doi.org/10.3389/fonc.2022.1088803" @default.
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