FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311858090> ?p ?o ?g. }

• W4311858090 abstract "Background Polyunsaturated fatty acids (PUFAs) are closely related to osteoporosis. To test their causal relationship, we conducted a Mendelian randomization (MR) analysis. Methods We analyzed the causal relationship between four PUFAs measures, n-3 PUFAs (n-3), n-6 PUFAs (n-6), the ratio of n-3 PUFAs to total fatty acids (n-3 pct), and the ratio of n-6 PUFAs to n-3 PUFAs (n-6 to n-3), and five measures of osteoporosis, including estimated bone mineral density (eBMD), forearm (FA) BMD, femoral neck (FN) BMD, lumbar spine (LS) BMD, and fracture, using two-sample MR analysis. In order to verify the direct effect between PUFAs and BMD, we chose interleukin-6 (IL-6), tumor necrosis factor-β (TNF-β), and bone morphogenetic proteins 7 (BMP-7), three markers or cytokines strongly related to BMD, as possible confounding factors, and analyzed the possible causal relationships between them and PUFAs or BMD by MR. Inverse variance weighting (IVW), MR-Egger, weighted and weighted median were conducted. MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) and MR-Egger regression methods were used to evaluate the potential pleiotropy of instrumental variables (IVs) and outliers were identified by MR-PRESSO. Cochran’s Q statistic was used to detect the heterogeneity among IVs. Leave-one-out sensitivity analysis was used to find SNPs that have a significant impact on the results. All results were corrected by the Bonferroni correction. Results The IVW results showed that n-3 PUFAs (OR = 1.030, 95% CI: 1.013, 1.047, P = 0.001) and n-6 PUFAs (OR = 1.053, 95% CI: 1.034, 1.072, P &lt; 0.001) were positively correlated with eBMD, while n-6 to n-3 (OR = 0.947, 95% CI: 0.924, 0.970, P &lt; 0.001) were negatively correlated with eBMD. These casual relationships still existed after Bonferroni correction. There were positive effects of n-3 PUFAs on FA BMD (OR = 1.090, 95% CI: 1.011, 1.176, P = 0.025) and LS BMD (OR = 1.056, 95% CI: 1.011, 1.104, P = 0.014), n-3 pct on eBMD (OR = 1.028, 95% CI: 1.002, 1.055, P = 0.035) and FA BMD (OR = 1.090, 95% CI: 1.011, 1.174, P = 0.025), n-6 to n-3 on LS BMD (OR = 1.071, 95% CI: 1.021, 1.124, P = 0.005); negative effects of n-3 pct on fracture (OR = 0.953, 95% CI: 0.918, 0.988, P = 0.009) and n-6 to n-3 on FA BMD (OR = 0.910, 95% CI: 0.837, 0.988, P = 0.025). However, these causal effects all disappeared after Bonferroni correction (all P &gt; 0.0025). None of IL-6, TNF-β, and BMP-7 had a causal effect on PUFA and BMD simultaneously (all P &gt; 0.05). Conclusion Evidence from this MR study supports the genetically predicted causal effects of n-3, n-6, n-3 pct, and n-6 to n-3 on eBMD. In addition, n-3 not only associate with FA BMD and LS BMD through its own level and n-6 to n-3, but also link to fracture through n-3 pct." @default.
• W4311858090 created "2023-01-01" @default.
• W4311858090 creator A5020651996 @default.
• W4311858090 creator A5024185697 @default.
• W4311858090 creator A5036665578 @default.
• W4311858090 creator A5040523461 @default.
• W4311858090 creator A5049078993 @default.
• W4311858090 creator A5057503770 @default.
• W4311858090 creator A5068559731 @default.
• W4311858090 creator A5082557728 @default.
• W4311858090 date "2022-12-08" @default.
• W4311858090 modified "2023-10-05" @default.
• W4311858090 title "Causal effect of polyunsaturated fatty acids on bone mineral density and fracture" @default.
• W4311858090 cites W1882326031 @default.
• W4311858090 cites W1902575419 @default.
• W4311858090 cites W1966247104 @default.
• W4311858090 cites W1972992681 @default.
• W4311858090 cites W1980371179 @default.
• W4311858090 cites W1982906652 @default.
• W4311858090 cites W1986633025 @default.
• W4311858090 cites W2001636656 @default.
• W4311858090 cites W2003790100 @default.
• W4311858090 cites W2006599766 @default.
• W4311858090 cites W2009288080 @default.
• W4311858090 cites W2031580166 @default.
• W4311858090 cites W2039913230 @default.
• W4311858090 cites W2046583479 @default.
• W4311858090 cites W2050772573 @default.
• W4311858090 cites W2062098709 @default.
• W4311858090 cites W2065083861 @default.
• W4311858090 cites W2081145904 @default.
• W4311858090 cites W2083593619 @default.
• W4311858090 cites W2085030821 @default.
• W4311858090 cites W2086593312 @default.
• W4311858090 cites W2088067037 @default.
• W4311858090 cites W2094356408 @default.
• W4311858090 cites W2097091269 @default.
• W4311858090 cites W2099026444 @default.
• W4311858090 cites W2106036991 @default.
• W4311858090 cites W2110396808 @default.
• W4311858090 cites W2113699335 @default.
• W4311858090 cites W2115438773 @default.
• W4311858090 cites W2116225262 @default.
• W4311858090 cites W2127598220 @default.
• W4311858090 cites W2136938277 @default.
• W4311858090 cites W2149592885 @default.
• W4311858090 cites W2150651546 @default.
• W4311858090 cites W2152799367 @default.
• W4311858090 cites W2154683361 @default.
• W4311858090 cites W2159003998 @default.
• W4311858090 cites W2166317809 @default.
• W4311858090 cites W2168584580 @default.
• W4311858090 cites W2169101435 @default.
• W4311858090 cites W2170259364 @default.
• W4311858090 cites W2171960277 @default.
• W4311858090 cites W2233974801 @default.
• W4311858090 cites W2257516528 @default.
• W4311858090 cites W2324862792 @default.
• W4311858090 cites W2411293705 @default.
• W4311858090 cites W2488281607 @default.
• W4311858090 cites W2566908060 @default.
• W4311858090 cites W2732630371 @default.
• W4311858090 cites W2767428727 @default.
• W4311858090 cites W2768238915 @default.
• W4311858090 cites W2803072880 @default.
• W4311858090 cites W2803761335 @default.
• W4311858090 cites W2805712258 @default.
• W4311858090 cites W2897073365 @default.
• W4311858090 cites W2904039649 @default.
• W4311858090 cites W2912904861 @default.
• W4311858090 cites W2938352109 @default.
• W4311858090 cites W2939859838 @default.
• W4311858090 cites W2950598813 @default.
• W4311858090 cites W2990451375 @default.
• W4311858090 cites W3011178617 @default.
• W4311858090 cites W3025880719 @default.
• W4311858090 cites W3035003081 @default.
• W4311858090 cites W3048546677 @default.
• W4311858090 cites W3083607101 @default.
• W4311858090 cites W3096594614 @default.
• W4311858090 cites W3151342826 @default.
• W4311858090 cites W3159102563 @default.
• W4311858090 cites W3172993534 @default.
• W4311858090 cites W3174763921 @default.
• W4311858090 cites W3177775180 @default.
• W4311858090 cites W3214966511 @default.
• W4311858090 cites W4211221406 @default.
• W4311858090 cites W4220998288 @default.
• W4311858090 cites W4255760144 @default.
• W4311858090 cites W4282549953 @default.
• W4311858090 cites W4283221287 @default.
• W4311858090 cites W4283721028 @default.
• W4311858090 cites W4285733494 @default.
• W4311858090 cites W4286493070 @default.
• W4311858090 doi "https://doi.org/10.3389/fnut.2022.1014847" @default.
• W4311858090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36570136" @default.
• W4311858090 hasPublicationYear "2022" @default.
• W4311858090 type Work @default.
• W4311858090 citedByCount "2" @default.
• W4311858090 countsByYear W43118580902023 @default.

• next