Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311858205> ?p ?o ?g. }
- W4311858205 abstract "CD36 is highly expressed in diverse tumor types and its expression correlates with advanced stages, poor prognosis, and reduced survival. In cancer cells, CD36: 1) increases fatty acid uptake, reprogramming lipid metabolism; 2) favors cancer cell proliferation, and 3) promotes epithelial-mesenchymal transition. Furthermore, CD36 expression correlates with the expression of cancer stem cell markers and CD36 + cancer cells display increased stemness functional properties, including clonogenicity, chemo- and radioresistance, and metastasis-initiating capability, suggesting CD36 is a marker of the cancer stem cell population. Thus, CD36 has been pointed as a potential therapeutic target in cancer. At present, at least three different types of molecules have been developed for reducing CD36-mediated functions: blocking monoclonal antibodies, small-molecule inhibitors, and compounds that knock-down CD36 expression. Herein, we review the role of CD36 in cancer progression, its participation in stemness control, as well as the efficacy of reported CD36 inhibitors in cancer cell cultures and animal models. Overall, the evidence compiled points that CD36 is a valid target for the development of new anti-cancer therapies." @default.
- W4311858205 created "2023-01-01" @default.
- W4311858205 creator A5036720067 @default.
- W4311858205 creator A5037388106 @default.
- W4311858205 creator A5046491065 @default.
- W4311858205 creator A5083165818 @default.
- W4311858205 date "2022-12-08" @default.
- W4311858205 modified "2023-10-13" @default.
- W4311858205 title "Role of CD36 in cancer progression, stemness, and targeting" @default.
- W4311858205 cites W1549631663 @default.
- W4311858205 cites W1656032348 @default.
- W4311858205 cites W1972938311 @default.
- W4311858205 cites W1978041336 @default.
- W4311858205 cites W1978527450 @default.
- W4311858205 cites W1978574835 @default.
- W4311858205 cites W1982229884 @default.
- W4311858205 cites W2007427970 @default.
- W4311858205 cites W2012153991 @default.
- W4311858205 cites W2016153546 @default.
- W4311858205 cites W2024597415 @default.
- W4311858205 cites W2026480865 @default.
- W4311858205 cites W2039872271 @default.
- W4311858205 cites W2041237929 @default.
- W4311858205 cites W2049409827 @default.
- W4311858205 cites W2053153144 @default.
- W4311858205 cites W2059095761 @default.
- W4311858205 cites W2064760068 @default.
- W4311858205 cites W2069931679 @default.
- W4311858205 cites W2071357722 @default.
- W4311858205 cites W2073126673 @default.
- W4311858205 cites W2079613095 @default.
- W4311858205 cites W2086713016 @default.
- W4311858205 cites W2097505836 @default.
- W4311858205 cites W2101332957 @default.
- W4311858205 cites W2107542389 @default.
- W4311858205 cites W2112703519 @default.
- W4311858205 cites W2121940835 @default.
- W4311858205 cites W2129974585 @default.
- W4311858205 cites W2130133905 @default.
- W4311858205 cites W2135272175 @default.
- W4311858205 cites W2140088548 @default.
- W4311858205 cites W2144479616 @default.
- W4311858205 cites W2146374265 @default.
- W4311858205 cites W2146971577 @default.
- W4311858205 cites W2151848257 @default.
- W4311858205 cites W2165261425 @default.
- W4311858205 cites W2196756223 @default.
- W4311858205 cites W2293238893 @default.
- W4311858205 cites W2305197880 @default.
- W4311858205 cites W2405125912 @default.
- W4311858205 cites W2460079669 @default.
- W4311858205 cites W2473447250 @default.
- W4311858205 cites W2516779680 @default.
- W4311858205 cites W2524443653 @default.
- W4311858205 cites W2560396365 @default.
- W4311858205 cites W2586169194 @default.
- W4311858205 cites W2590361390 @default.
- W4311858205 cites W2600452401 @default.
- W4311858205 cites W2734141593 @default.
- W4311858205 cites W2735749161 @default.
- W4311858205 cites W2742242827 @default.
- W4311858205 cites W2775901890 @default.
- W4311858205 cites W2786004990 @default.
- W4311858205 cites W2791850957 @default.
- W4311858205 cites W2793124274 @default.
- W4311858205 cites W2800195175 @default.
- W4311858205 cites W2805632139 @default.
- W4311858205 cites W2808105555 @default.
- W4311858205 cites W2890074591 @default.
- W4311858205 cites W2900489601 @default.
- W4311858205 cites W2903961424 @default.
- W4311858205 cites W2904384577 @default.
- W4311858205 cites W2909129516 @default.
- W4311858205 cites W2913214687 @default.
- W4311858205 cites W2921955101 @default.
- W4311858205 cites W2937672062 @default.
- W4311858205 cites W2940616254 @default.
- W4311858205 cites W2941184640 @default.
- W4311858205 cites W2962908114 @default.
- W4311858205 cites W2971698053 @default.
- W4311858205 cites W2972396522 @default.
- W4311858205 cites W2979459823 @default.
- W4311858205 cites W2982093765 @default.
- W4311858205 cites W2995654976 @default.
- W4311858205 cites W3001536266 @default.
- W4311858205 cites W3006222581 @default.
- W4311858205 cites W3007883076 @default.
- W4311858205 cites W3010368316 @default.
- W4311858205 cites W3021040864 @default.
- W4311858205 cites W3024628788 @default.
- W4311858205 cites W3033903233 @default.
- W4311858205 cites W3039050968 @default.
- W4311858205 cites W3039560322 @default.
- W4311858205 cites W3045830102 @default.
- W4311858205 cites W3045990787 @default.
- W4311858205 cites W3082548205 @default.
- W4311858205 cites W3087320494 @default.
- W4311858205 cites W3121176046 @default.
- W4311858205 cites W3128646645 @default.
- W4311858205 cites W3137347659 @default.