Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311860136> ?p ?o ?g. }
- W4311860136 endingPage "2083" @default.
- W4311860136 startingPage "2069" @default.
- W4311860136 abstract "Abstract Optimal performance of the central nervous system (CNS) depends on dynamic, multidirectional communication between different cell types both within and without the CNS to maintain the homeostatic environment. Ageing, in turn, is associated with CNS disequilibrium resulting in suboptimal functioning of its cells and potential cognitive impairment. Emerging evidence indicates that inter‐organ communication influences the functioning of CNS cell types, which are subject to age‐ and environment‐dependent alterations. Endurance exercise has specifically been demonstrated to have a marked impact on neuroimmune communications, particularly those involving microglia, the resident macrophages of the CNS parenchyma, as well as microglia–astrocyte interactions in rodents. Via its action on CNS glial cells, regular aerobic exercise has been shown to provide an adaptive advantage against perturbations to homeostasis, such as immunological challenge or ageing. In light of the accumulating evidence and evolutionary reasoning it may be argued that recurrent exercise‐associated inter‐organ signalling is necessary for the optimisation of glial function and hence CNS equilibrium. This, in turn, would imply that the absence of exercise‐derived mediators and dysregulated inter‐organ communication associated with a sedentary lifestyle may contribute to CNS dyshomeostasis, which is accelerated during ageing. As well as exploring the evidence of the impact of exercise on glial function, here we suggest potential next steps in identifying the mechanistic underpinnings of these effects and the potential importance of sex differences. image" @default.
- W4311860136 created "2023-01-01" @default.
- W4311860136 creator A5009560918 @default.
- W4311860136 creator A5035288942 @default.
- W4311860136 creator A5086085700 @default.
- W4311860136 date "2022-12-18" @default.
- W4311860136 modified "2023-10-11" @default.
- W4311860136 title "Exercise‐induced modulation of neuroinflammation in ageing" @default.
- W4311860136 cites W1514204750 @default.
- W4311860136 cites W1515023627 @default.
- W4311860136 cites W1531365070 @default.
- W4311860136 cites W1544249031 @default.
- W4311860136 cites W1579300888 @default.
- W4311860136 cites W1597116068 @default.
- W4311860136 cites W1920112865 @default.
- W4311860136 cites W1959902108 @default.
- W4311860136 cites W1963663193 @default.
- W4311860136 cites W1969619562 @default.
- W4311860136 cites W1983102049 @default.
- W4311860136 cites W1989049076 @default.
- W4311860136 cites W1992383112 @default.
- W4311860136 cites W1993152909 @default.
- W4311860136 cites W2001725826 @default.
- W4311860136 cites W2016927879 @default.
- W4311860136 cites W2023572776 @default.
- W4311860136 cites W2031811366 @default.
- W4311860136 cites W2035072797 @default.
- W4311860136 cites W2035471044 @default.
- W4311860136 cites W2047745765 @default.
- W4311860136 cites W2050015055 @default.
- W4311860136 cites W2050048961 @default.
- W4311860136 cites W2059109913 @default.
- W4311860136 cites W2059143929 @default.
- W4311860136 cites W2066191550 @default.
- W4311860136 cites W2070476787 @default.
- W4311860136 cites W2080127654 @default.
- W4311860136 cites W2088101528 @default.
- W4311860136 cites W2089621097 @default.
- W4311860136 cites W2094660330 @default.
- W4311860136 cites W2095293130 @default.
- W4311860136 cites W2098685543 @default.
- W4311860136 cites W2117415152 @default.
- W4311860136 cites W2118884820 @default.
- W4311860136 cites W2123716968 @default.
- W4311860136 cites W2125363991 @default.
- W4311860136 cites W2127684472 @default.
- W4311860136 cites W2128895419 @default.
- W4311860136 cites W2129155846 @default.
- W4311860136 cites W2129231920 @default.
- W4311860136 cites W2130853169 @default.
- W4311860136 cites W2131196982 @default.
- W4311860136 cites W2136855986 @default.
- W4311860136 cites W2141091113 @default.
- W4311860136 cites W2144041807 @default.
- W4311860136 cites W2145890122 @default.
- W4311860136 cites W2147515151 @default.
- W4311860136 cites W2148764339 @default.
- W4311860136 cites W2151003930 @default.
- W4311860136 cites W2157554312 @default.
- W4311860136 cites W2163410184 @default.
- W4311860136 cites W2165302236 @default.
- W4311860136 cites W2167498879 @default.
- W4311860136 cites W2177834950 @default.
- W4311860136 cites W2191169263 @default.
- W4311860136 cites W2254521523 @default.
- W4311860136 cites W2326950591 @default.
- W4311860136 cites W2333123302 @default.
- W4311860136 cites W2505997744 @default.
- W4311860136 cites W2520720701 @default.
- W4311860136 cites W2522038806 @default.
- W4311860136 cites W2525374103 @default.
- W4311860136 cites W2528335443 @default.
- W4311860136 cites W2565533470 @default.
- W4311860136 cites W2584889633 @default.
- W4311860136 cites W2597537821 @default.
- W4311860136 cites W2612808369 @default.
- W4311860136 cites W2614586381 @default.
- W4311860136 cites W2753593979 @default.
- W4311860136 cites W2765155499 @default.
- W4311860136 cites W2766890970 @default.
- W4311860136 cites W2772820943 @default.
- W4311860136 cites W2774942753 @default.
- W4311860136 cites W2782804476 @default.
- W4311860136 cites W2787301818 @default.
- W4311860136 cites W2800808913 @default.
- W4311860136 cites W2804794646 @default.
- W4311860136 cites W2808882111 @default.
- W4311860136 cites W2884081989 @default.
- W4311860136 cites W2888795447 @default.
- W4311860136 cites W2897300390 @default.
- W4311860136 cites W2909217338 @default.
- W4311860136 cites W2910358458 @default.
- W4311860136 cites W2922129951 @default.
- W4311860136 cites W2931439260 @default.
- W4311860136 cites W2937273526 @default.
- W4311860136 cites W2942242324 @default.
- W4311860136 cites W2942979371 @default.
- W4311860136 cites W2947647528 @default.