Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311860185> ?p ?o ?g. }
- W4311860185 abstract "Breast cancer is a complex, highly heterogenous, and dynamic disease and the leading cause of cancer-related death in women worldwide. Evaluation of the heterogeneity of breast cancer and its various subtypes is crucial to identify novel treatment strategies that can overcome the limitations of currently available options. Explant cultures of human mammary tissue have been known to provide important insights for the study of breast cancer structure and phenotype as they include the context of the surrounding microenvironment, allowing for the comprehensive exploration of patient heterogeneity. However, the major limitation of currently available techniques remains the short-term viability of the tissue owing to loss of structural integrity. Here, an ex vivo culture model using star-shaped poly(ethylene glycol) and maleimide-functionalized heparin (PEG-HM) hydrogels to provide structural support to the explant cultures is presented. The mechanical support allows the culture of the human mammary tissue for up to 3 weeks and prevent disintegration of the cellular structures including the epithelium and surrounding stromal tissue. Further, maintenance of epithelial phenotype and hormonal receptors is observed for up to 2 weeks of culture which makes them relevant for testing therapeutic interventions. Through this study, the importance of donor-to-donor variability and intra-patient tissue heterogeneity is reiterated." @default.
- W4311860185 created "2023-01-01" @default.
- W4311860185 creator A5002940759 @default.
- W4311860185 creator A5003215109 @default.
- W4311860185 creator A5009753421 @default.
- W4311860185 creator A5011316999 @default.
- W4311860185 creator A5011486412 @default.
- W4311860185 creator A5027301367 @default.
- W4311860185 creator A5028203908 @default.
- W4311860185 creator A5035534488 @default.
- W4311860185 creator A5042026897 @default.
- W4311860185 creator A5049534595 @default.
- W4311860185 creator A5049598090 @default.
- W4311860185 creator A5052763324 @default.
- W4311860185 creator A5055057497 @default.
- W4311860185 creator A5067782015 @default.
- W4311860185 creator A5074314628 @default.
- W4311860185 creator A5075948104 @default.
- W4311860185 date "2023-01-04" @default.
- W4311860185 modified "2023-10-10" @default.
- W4311860185 title "Exploring the Potential of PEG‐Heparin Hydrogels to Support Long‐Term Ex Vivo Culture of Patient‐Derived Breast Explant Tissues" @default.
- W4311860185 cites W1503890861 @default.
- W4311860185 cites W1519764726 @default.
- W4311860185 cites W1757407923 @default.
- W4311860185 cites W1966608995 @default.
- W4311860185 cites W1974208182 @default.
- W4311860185 cites W1979086975 @default.
- W4311860185 cites W1980324695 @default.
- W4311860185 cites W1996706031 @default.
- W4311860185 cites W2012874533 @default.
- W4311860185 cites W2034269086 @default.
- W4311860185 cites W2041098734 @default.
- W4311860185 cites W2046359623 @default.
- W4311860185 cites W2065204747 @default.
- W4311860185 cites W2082225160 @default.
- W4311860185 cites W2117733417 @default.
- W4311860185 cites W2141705055 @default.
- W4311860185 cites W2162647235 @default.
- W4311860185 cites W2254244961 @default.
- W4311860185 cites W2587991154 @default.
- W4311860185 cites W2591628935 @default.
- W4311860185 cites W2600430749 @default.
- W4311860185 cites W2619354363 @default.
- W4311860185 cites W2754930532 @default.
- W4311860185 cites W2886972375 @default.
- W4311860185 cites W2952481429 @default.
- W4311860185 cites W2971190139 @default.
- W4311860185 cites W2999984340 @default.
- W4311860185 cites W3027676014 @default.
- W4311860185 cites W3049372353 @default.
- W4311860185 cites W3123429969 @default.
- W4311860185 cites W4200381606 @default.
- W4311860185 doi "https://doi.org/10.1002/adhm.202202202" @default.
- W4311860185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36527735" @default.
- W4311860185 hasPublicationYear "2023" @default.
- W4311860185 type Work @default.
- W4311860185 citedByCount "1" @default.
- W4311860185 crossrefType "journal-article" @default.
- W4311860185 hasAuthorship W4311860185A5002940759 @default.
- W4311860185 hasAuthorship W4311860185A5003215109 @default.
- W4311860185 hasAuthorship W4311860185A5009753421 @default.
- W4311860185 hasAuthorship W4311860185A5011316999 @default.
- W4311860185 hasAuthorship W4311860185A5011486412 @default.
- W4311860185 hasAuthorship W4311860185A5027301367 @default.
- W4311860185 hasAuthorship W4311860185A5028203908 @default.
- W4311860185 hasAuthorship W4311860185A5035534488 @default.
- W4311860185 hasAuthorship W4311860185A5042026897 @default.
- W4311860185 hasAuthorship W4311860185A5049534595 @default.
- W4311860185 hasAuthorship W4311860185A5049598090 @default.
- W4311860185 hasAuthorship W4311860185A5052763324 @default.
- W4311860185 hasAuthorship W4311860185A5055057497 @default.
- W4311860185 hasAuthorship W4311860185A5067782015 @default.
- W4311860185 hasAuthorship W4311860185A5074314628 @default.
- W4311860185 hasAuthorship W4311860185A5075948104 @default.
- W4311860185 hasBestOaLocation W43118601851 @default.
- W4311860185 hasConcept C108586683 @default.
- W4311860185 hasConcept C121608353 @default.
- W4311860185 hasConcept C126322002 @default.
- W4311860185 hasConcept C150903083 @default.
- W4311860185 hasConcept C151730666 @default.
- W4311860185 hasConcept C157890192 @default.
- W4311860185 hasConcept C16930146 @default.
- W4311860185 hasConcept C178790620 @default.
- W4311860185 hasConcept C185592680 @default.
- W4311860185 hasConcept C202751555 @default.
- W4311860185 hasConcept C207001950 @default.
- W4311860185 hasConcept C26291073 @default.
- W4311860185 hasConcept C2779343474 @default.
- W4311860185 hasConcept C28483552 @default.
- W4311860185 hasConcept C502942594 @default.
- W4311860185 hasConcept C530470458 @default.
- W4311860185 hasConcept C54355233 @default.
- W4311860185 hasConcept C55493867 @default.
- W4311860185 hasConcept C71924100 @default.
- W4311860185 hasConcept C81885089 @default.
- W4311860185 hasConcept C86803240 @default.
- W4311860185 hasConceptScore W4311860185C108586683 @default.
- W4311860185 hasConceptScore W4311860185C121608353 @default.
- W4311860185 hasConceptScore W4311860185C126322002 @default.
- W4311860185 hasConceptScore W4311860185C150903083 @default.