Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311862330> ?p ?o ?g. }
- W4311862330 endingPage "1835" @default.
- W4311862330 startingPage "1835" @default.
- W4311862330 abstract "Diffuse large B-cell lymphoma (DLBCL), the most common type of Non-Hodgkin's Lymphoma (NHL), has a lethal nature. Thus, the establishment of a novel model to predict the prognosis of DLBCL and guide its therapy is an urgency. Meanwhile, pyroptosis is engaged in the progression of DLBCL with further investigations required to reveal the underlying mechanism.LASSO regression was conducted to establish a risk model based on those PRGs. External datasets, RT-qPCR and IHC images from The Human Protein Alta (HPA) database were utilized to validate the model. ssGSEA was utilized to estimate the score of immune components in DLBCL.A model based on 8 PRGs was established to generate a risk score. Validation of the model confirmed its robust performance. The risk score was associated with advanced clinical stages and shorter overall survivals. Two novel second-line chemotherapies were found to be potential treatments for high-risk patients. The risk score was also found to be correlated with immune components in DLBCL.This novel model can be utilized in clinical practices to predict the prognosis of DLBCL and guide the treatment of patients at high risk, providing an overview of immune regulatory program via pyroptosis in DLBCL." @default.
- W4311862330 created "2023-01-01" @default.
- W4311862330 creator A5008581678 @default.
- W4311862330 creator A5013305484 @default.
- W4311862330 creator A5026622910 @default.
- W4311862330 creator A5073505323 @default.
- W4311862330 date "2022-12-08" @default.
- W4311862330 modified "2023-09-26" @default.
- W4311862330 title "A Novel and Validated 8-Pyroptosis-Related Genes Based Risk Prediction Model for Diffuse Large B Cell Lymphoma" @default.
- W4311862330 cites W1020989877 @default.
- W4311862330 cites W1517889790 @default.
- W4311862330 cites W1963867859 @default.
- W4311862330 cites W1984660431 @default.
- W4311862330 cites W2107972068 @default.
- W4311862330 cites W2127936722 @default.
- W4311862330 cites W2147246240 @default.
- W4311862330 cites W2155381255 @default.
- W4311862330 cites W2159707944 @default.
- W4311862330 cites W2163818477 @default.
- W4311862330 cites W2168420784 @default.
- W4311862330 cites W2265419075 @default.
- W4311862330 cites W2517997111 @default.
- W4311862330 cites W2523249281 @default.
- W4311862330 cites W2562685286 @default.
- W4311862330 cites W2767190628 @default.
- W4311862330 cites W2768847879 @default.
- W4311862330 cites W2797584152 @default.
- W4311862330 cites W2895833591 @default.
- W4311862330 cites W2921072067 @default.
- W4311862330 cites W2945525000 @default.
- W4311862330 cites W2989083977 @default.
- W4311862330 cites W3011682876 @default.
- W4311862330 cites W3111627896 @default.
- W4311862330 cites W3134205746 @default.
- W4311862330 cites W3136050350 @default.
- W4311862330 cites W3137135974 @default.
- W4311862330 cites W3142080073 @default.
- W4311862330 cites W3200608395 @default.
- W4311862330 cites W3212281051 @default.
- W4311862330 cites W4210530293 @default.
- W4311862330 cites W4221048790 @default.
- W4311862330 cites W4226005224 @default.
- W4311862330 cites W4291511795 @default.
- W4311862330 cites W4292458142 @default.
- W4311862330 doi "https://doi.org/10.3390/biom12121835" @default.
- W4311862330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36551263" @default.
- W4311862330 hasPublicationYear "2022" @default.
- W4311862330 type Work @default.
- W4311862330 citedByCount "0" @default.
- W4311862330 crossrefType "journal-article" @default.
- W4311862330 hasAuthorship W4311862330A5008581678 @default.
- W4311862330 hasAuthorship W4311862330A5013305484 @default.
- W4311862330 hasAuthorship W4311862330A5026622910 @default.
- W4311862330 hasAuthorship W4311862330A5073505323 @default.
- W4311862330 hasBestOaLocation W43118623301 @default.
- W4311862330 hasConcept C112930515 @default.
- W4311862330 hasConcept C126322002 @default.
- W4311862330 hasConcept C136764020 @default.
- W4311862330 hasConcept C143998085 @default.
- W4311862330 hasConcept C203014093 @default.
- W4311862330 hasConcept C2778559949 @default.
- W4311862330 hasConcept C2779338263 @default.
- W4311862330 hasConcept C2986432223 @default.
- W4311862330 hasConcept C37616216 @default.
- W4311862330 hasConcept C41008148 @default.
- W4311862330 hasConcept C50382708 @default.
- W4311862330 hasConcept C71924100 @default.
- W4311862330 hasConcept C8891405 @default.
- W4311862330 hasConceptScore W4311862330C112930515 @default.
- W4311862330 hasConceptScore W4311862330C126322002 @default.
- W4311862330 hasConceptScore W4311862330C136764020 @default.
- W4311862330 hasConceptScore W4311862330C143998085 @default.
- W4311862330 hasConceptScore W4311862330C203014093 @default.
- W4311862330 hasConceptScore W4311862330C2778559949 @default.
- W4311862330 hasConceptScore W4311862330C2779338263 @default.
- W4311862330 hasConceptScore W4311862330C2986432223 @default.
- W4311862330 hasConceptScore W4311862330C37616216 @default.
- W4311862330 hasConceptScore W4311862330C41008148 @default.
- W4311862330 hasConceptScore W4311862330C50382708 @default.
- W4311862330 hasConceptScore W4311862330C71924100 @default.
- W4311862330 hasConceptScore W4311862330C8891405 @default.
- W4311862330 hasIssue "12" @default.
- W4311862330 hasLocation W43118623301 @default.
- W4311862330 hasLocation W43118623302 @default.
- W4311862330 hasLocation W43118623303 @default.
- W4311862330 hasLocation W43118623304 @default.
- W4311862330 hasOpenAccess W4311862330 @default.
- W4311862330 hasPrimaryLocation W43118623301 @default.
- W4311862330 hasRelatedWork W2386146283 @default.
- W4311862330 hasRelatedWork W2985798777 @default.
- W4311862330 hasRelatedWork W3131814850 @default.
- W4311862330 hasRelatedWork W3134135558 @default.
- W4311862330 hasRelatedWork W3156052029 @default.
- W4311862330 hasRelatedWork W3200659145 @default.
- W4311862330 hasRelatedWork W3209608268 @default.
- W4311862330 hasRelatedWork W4205198487 @default.
- W4311862330 hasRelatedWork W4250817001 @default.
- W4311862330 hasRelatedWork W4288684817 @default.