Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311863028> ?p ?o ?g. }
- W4311863028 endingPage "903" @default.
- W4311863028 startingPage "891" @default.
- W4311863028 abstract "Abstract Context Studies using experimental models have demonstrated that prebiotics are involved in antiosteoporotic mechanisms. Objective This study was conducted to determine the impact of supplementation with prebiotics in the basal diet of ovariectomized rats with induced osteoporosis as a preclinical model. Methods A comprehensive systematic search was carried out in the electronic databases PubMed, Science Direct, Web of Science, Scielo, and Google through March 2022 for studies that investigated the impact of prebiotics on bone mineral density (BMD), bone mineral content (BMC), and bone biomechanics. Results The search returned 844 complete articles, abstracts, or book chapters. After detailed screening, 8 studies met the inclusion criteria. Rats (n = 206), were randomly divided between control and treatment groups. Weighted mean differences (WMDs) with the 95%CIs were used to estimate the combined effect size. Compared with the control group, dietary intake of prebiotics significantly increased bone density in the BMD subgroups, with WMDs as follows: 0.03 g/cm3, 95%CI, 0.01–0.05, P < 0.00001, n = 46; and 0.00 g/cm2, 95%CI, 0.00–0.02, P < 0.00001, n = 81; total BMD: WMD, 0.01, 95%CI, 0.01–0.02, P < 0.00001, n = 127; bone content in BMC: WMD, 0.02 g, 95%CI, 0.00–0.04, P = 0.05, n = 107; and the 3-point-bend test: WMD, 15.20 N, 95%CI, 5.92–24.47, P = 0.00001, n = 120. Conclusion Prebiotics improve indicators of osteoporosis, BMD, BMC, and bone biomechanics in ovariectomized rats. More studies are needed to increase the level of evidence. Systemic Review Registration Systematic Review Protocol for Animal Intervention Studies" @default.
- W4311863028 created "2023-01-01" @default.
- W4311863028 creator A5001631409 @default.
- W4311863028 creator A5017648644 @default.
- W4311863028 creator A5032143453 @default.
- W4311863028 creator A5063016951 @default.
- W4311863028 creator A5065093556 @default.
- W4311863028 creator A5068528008 @default.
- W4311863028 creator A5072955792 @default.
- W4311863028 creator A5081526230 @default.
- W4311863028 date "2022-12-06" @default.
- W4311863028 modified "2023-10-16" @default.
- W4311863028 title "Prebiotics improve osteoporosis indicators in a preclinical model: systematic review with meta-analysis" @default.
- W4311863028 cites W1236775670 @default.
- W4311863028 cites W1512024602 @default.
- W4311863028 cites W1531070430 @default.
- W4311863028 cites W1682365470 @default.
- W4311863028 cites W1854981564 @default.
- W4311863028 cites W1950977525 @default.
- W4311863028 cites W1953108821 @default.
- W4311863028 cites W1960324740 @default.
- W4311863028 cites W1972295589 @default.
- W4311863028 cites W1981624282 @default.
- W4311863028 cites W1983453825 @default.
- W4311863028 cites W1984640787 @default.
- W4311863028 cites W1986300508 @default.
- W4311863028 cites W1991761975 @default.
- W4311863028 cites W1999172324 @default.
- W4311863028 cites W2002231140 @default.
- W4311863028 cites W2002604531 @default.
- W4311863028 cites W2024660450 @default.
- W4311863028 cites W2026674030 @default.
- W4311863028 cites W2027251089 @default.
- W4311863028 cites W2030520823 @default.
- W4311863028 cites W2041751047 @default.
- W4311863028 cites W2043023589 @default.
- W4311863028 cites W2047176148 @default.
- W4311863028 cites W2048786430 @default.
- W4311863028 cites W2052032846 @default.
- W4311863028 cites W2059573662 @default.
- W4311863028 cites W2060972268 @default.
- W4311863028 cites W2066291487 @default.
- W4311863028 cites W2067233247 @default.
- W4311863028 cites W2075825857 @default.
- W4311863028 cites W2086442345 @default.
- W4311863028 cites W2087683309 @default.
- W4311863028 cites W2095211990 @default.
- W4311863028 cites W2100045956 @default.
- W4311863028 cites W2108677891 @default.
- W4311863028 cites W2115444192 @default.
- W4311863028 cites W2116972096 @default.
- W4311863028 cites W2120772838 @default.
- W4311863028 cites W2130916057 @default.
- W4311863028 cites W2139542843 @default.
- W4311863028 cites W2144081914 @default.
- W4311863028 cites W2152593913 @default.
- W4311863028 cites W2161374186 @default.
- W4311863028 cites W2306208570 @default.
- W4311863028 cites W2403549948 @default.
- W4311863028 cites W2484307946 @default.
- W4311863028 cites W2559809466 @default.
- W4311863028 cites W2627092521 @default.
- W4311863028 cites W2732630371 @default.
- W4311863028 cites W2755198076 @default.
- W4311863028 cites W2767047143 @default.
- W4311863028 cites W2778082937 @default.
- W4311863028 cites W2790194570 @default.
- W4311863028 cites W2805011372 @default.
- W4311863028 cites W2805199058 @default.
- W4311863028 cites W2806145046 @default.
- W4311863028 cites W2888996163 @default.
- W4311863028 cites W2901898635 @default.
- W4311863028 cites W2910397657 @default.
- W4311863028 cites W2914747969 @default.
- W4311863028 cites W2923700276 @default.
- W4311863028 cites W2940747379 @default.
- W4311863028 cites W2945294321 @default.
- W4311863028 cites W2954347477 @default.
- W4311863028 cites W2971983803 @default.
- W4311863028 cites W2994283760 @default.
- W4311863028 cites W2995739843 @default.
- W4311863028 cites W3001069296 @default.
- W4311863028 cites W3001377667 @default.
- W4311863028 cites W3011598538 @default.
- W4311863028 cites W3024806705 @default.
- W4311863028 cites W3024889933 @default.
- W4311863028 cites W3026454306 @default.
- W4311863028 cites W3029149893 @default.
- W4311863028 cites W3034368928 @default.
- W4311863028 cites W3041328799 @default.
- W4311863028 cites W3082293306 @default.
- W4311863028 cites W3082895404 @default.
- W4311863028 cites W3100724913 @default.
- W4311863028 cites W3112413644 @default.
- W4311863028 cites W3134566001 @default.
- W4311863028 cites W3153284922 @default.
- W4311863028 cites W4205189017 @default.
- W4311863028 cites W4205892246 @default.