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- W4311863315 endingPage "501" @default.
- W4311863315 startingPage "484" @default.
- W4311863315 abstract "Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent deacetylase, is a cellular regulator that has received extensive attention in recent years and regarded as a sensor of cellular energy and metabolism. The accumulated evidence suggests that SIRT1 is involved in the development of endocrine and metabolic diseases. In a variety of organisms, SIRT1 regulates gene expression through the deacetylation of histone, transcription factors, and lysine residues of other modified proteins including several metabolic and endocrine signal transcription factors, thereby enhancing the therapeutic effects of endocrine and metabolic diseases. These evidences indicate that targeting SIRT1 has promising applications in the treatment of endocrine and metabolic diseases. This review focuses on the role of SIRT1 in endocrine and metabolic diseases. First, we describe the background and structure of SIRT1. Then, we outline the role of SIRT1 in endocrine and metabolic diseases such as hyperuricemia, diabetes, hypertension, hyperlipidemia, osteoporosis, and polycystic ovarian syndrome. Subsequently, the SIRT1 agonists and inhibitors in the above diseases are summarized and future research directions are proposed. Overall, the information presents here may highlight the potential of SIRT1 as a future biomarker and therapeutic target for endocrine and metabolic diseases." @default.
- W4311863315 created "2023-01-01" @default.
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- W4311863315 date "2023-01-01" @default.
- W4311863315 modified "2023-10-16" @default.
- W4311863315 title "Novel Role of the SIRT1 in Endocrine and Metabolic Diseases" @default.
- W4311863315 cites W1418192292 @default.
- W4311863315 cites W1508727117 @default.
- W4311863315 cites W1566019730 @default.
- W4311863315 cites W1588051322 @default.
- W4311863315 cites W1791865091 @default.
- W4311863315 cites W1929991616 @default.
- W4311863315 cites W1968213511 @default.
- W4311863315 cites W1968583736 @default.
- W4311863315 cites W1969408132 @default.
- W4311863315 cites W1969454293 @default.
- W4311863315 cites W1971554340 @default.
- W4311863315 cites W1972556189 @default.
- W4311863315 cites W1973163466 @default.
- W4311863315 cites W1974547058 @default.
- W4311863315 cites W1981682594 @default.
- W4311863315 cites W1985308585 @default.
- W4311863315 cites W1985599023 @default.
- W4311863315 cites W1987616871 @default.
- W4311863315 cites W1988012917 @default.
- W4311863315 cites W1991274029 @default.
- W4311863315 cites W1996094302 @default.
- W4311863315 cites W1996842235 @default.
- W4311863315 cites W1997145913 @default.
- W4311863315 cites W2001686534 @default.
- W4311863315 cites W2001722745 @default.
- W4311863315 cites W2002724633 @default.
- W4311863315 cites W2005526533 @default.
- W4311863315 cites W2007541295 @default.
- W4311863315 cites W2007842741 @default.
- W4311863315 cites W2008816560 @default.
- W4311863315 cites W2008997630 @default.
- W4311863315 cites W2010992748 @default.
- W4311863315 cites W2011030822 @default.
- W4311863315 cites W2012417173 @default.
- W4311863315 cites W2013466700 @default.
- W4311863315 cites W2014236527 @default.
- W4311863315 cites W2014610203 @default.
- W4311863315 cites W2015107929 @default.
- W4311863315 cites W2016587814 @default.
- W4311863315 cites W2020222860 @default.
- W4311863315 cites W2021631452 @default.
- W4311863315 cites W2021868734 @default.
- W4311863315 cites W2025674512 @default.
- W4311863315 cites W2026168844 @default.
- W4311863315 cites W2027238333 @default.
- W4311863315 cites W2027616087 @default.
- W4311863315 cites W2028625066 @default.
- W4311863315 cites W2032978056 @default.
- W4311863315 cites W2036691084 @default.
- W4311863315 cites W2041295404 @default.
- W4311863315 cites W2043932983 @default.
- W4311863315 cites W2044626025 @default.
- W4311863315 cites W2046205800 @default.
- W4311863315 cites W2048025500 @default.
- W4311863315 cites W2061914685 @default.
- W4311863315 cites W2062360005 @default.
- W4311863315 cites W2071298886 @default.
- W4311863315 cites W2072103472 @default.
- W4311863315 cites W2078023359 @default.
- W4311863315 cites W2078985284 @default.
- W4311863315 cites W2082340869 @default.
- W4311863315 cites W2084347969 @default.
- W4311863315 cites W2089963587 @default.
- W4311863315 cites W2092621283 @default.
- W4311863315 cites W2094807579 @default.
- W4311863315 cites W2099020218 @default.
- W4311863315 cites W2099267774 @default.
- W4311863315 cites W2099760082 @default.
- W4311863315 cites W2100076759 @default.
- W4311863315 cites W2100784798 @default.
- W4311863315 cites W2102536188 @default.
- W4311863315 cites W2104035332 @default.
- W4311863315 cites W2109138478 @default.
- W4311863315 cites W2110118637 @default.
- W4311863315 cites W2112936536 @default.
- W4311863315 cites W2114102299 @default.
- W4311863315 cites W2114957061 @default.
- W4311863315 cites W2115292404 @default.
- W4311863315 cites W2115750021 @default.
- W4311863315 cites W2116350182 @default.
- W4311863315 cites W2121839388 @default.