Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311871033> ?p ?o ?g. }
- W4311871033 abstract "The functional state of chimeric antigen receptor T (CAR T) cells determines their efficacy in vivo. Exhausted CAR T cells exhibit decreased proliferative capacity, impaired anti-tumor activity, and attenuated persistence. CAR T cell exhaustion has been recognized as a vital cause of nonresponse and relapse after CAR T cell therapy. However, the triggers and mechanisms leading to CAR T cell exhaustion remain blurry and complicated. Therefore, it is essential to clear the regulation network of CAR T cell exhaustion and explore potent solutions. Here, we review the diverse inducers of CAR T cell exhaustion in terms of manufacture process and immunosuppressive tumor microenvironment. In addition to the admitted immune checkpoint blockade, we also describe promising strategies that may reverse CAR T cell exhaustion including targeting the tumor microenvironment, epigenetics and transcriptomics." @default.
- W4311871033 created "2023-01-01" @default.
- W4311871033 creator A5053780153 @default.
- W4311871033 creator A5055471482 @default.
- W4311871033 creator A5091497699 @default.
- W4311871033 date "2022-12-08" @default.
- W4311871033 modified "2023-10-01" @default.
- W4311871033 title "Mechanisms of CAR T cell exhaustion and current counteraction strategies" @default.
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- W4311871033 doi "https://doi.org/10.3389/fcell.2022.1034257" @default.
- W4311871033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36568989" @default.
- W4311871033 hasPublicationYear "2022" @default.
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