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• W4311872724 abstract "To date, no interventional trial has assessed the efficacy and safety of vonoprazan and high-dose (500 mg four times daily, 2000 mg/day) amoxicillin dual therapy in terms of Helicobacter pylori eradication. We explored whether this was an appropriate first-line treatment.This prospective, dual-center, single-arm interventional study was performed in Japan. Twenty H. pylori-positive patients lacking any eradication history were treated with vonoprazan 20 mg twice daily and amoxicillin 500 mg four times daily (qid) for 7 days. Eradication was evaluated using a stool H. pylori antigen test. We evaluated safety using patient questionnaires. This study was registered in the jRCT database (jRCT031200128).The intention-to-treat and per-protocol eradication rates were 90% (95% confidence interval [CI] 68.3-98.8%, n = 20) and 94.4% (95% CI 72.7-99.9%, n = 18) respectively. No significant adverse event was recorded.Vonoprazan/high-dose amoxicillin dual therapy can be a safe standard first-line therapy. We are now undergoing a randomized controlled trial comparing dual therapy and vonoprazan-based triple therapy." @default.
• W4311872724 created "2023-01-02" @default.
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• W4311872724 date "2022-12-08" @default.
• W4311872724 modified "2023-10-05" @default.
• W4311872724 title "Vonoprazan and high‐dose amoxicillin dual therapy for <i>Helicobacter pylori</i> first‐line eradication: A single‐arm, interventional study" @default.
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• W4311872724 doi "https://doi.org/10.1002/jgh3.12852" @default.
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