FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311872728> ?p ?o ?g. }

• W4311872728 abstract "Introduction This study was conducted to evaluate the predictive values of volumetric parameters and radiomic features (RFs) extracted from pretreatment 68Ga-PSMA PET and baseline clinical parameters in response to 177Lu-PSMA therapy. Materials and methods In this retrospective multicenter study, mCRPC patients undergoing 177Lu-PSMA therapy were enrolled. According to the outcome of therapy, the patients were classified into two groups including positive biochemical response (BCR) (≥ 50% reduction in the serum PSA value) and negative BCR (&lt; 50%). Sixty-five RFs, eight volumetric parameters, and also seventeen clinical parameters were evaluated for the prediction of BCR. In addition, the impact of such parameters on overall survival (OS) was evaluated. Results 33 prostate cancer patients with a median age of 69 years (range: 49-89) were enrolled. BCR was observed in 22 cases (66%), and 16 cases (48.5%) died during the follow-up time. The results of Spearman correlation test indicated a significant relationship between BCR and treatment cycle, administered dose, HISTO energy, GLCM entropy, and GLZLM LZLGE (p&lt;0.05). In addition, according to the Mann-Whitney U test, age, cycle, dose, GLCM entropy, and GLZLM LZLGE were significantly different between BCR and non BCR patients (p&lt;0.05). According to the ROC curve analysis for feature selection for prediction of BCR, GLCM entropy, age, treatment cycle, and administered dose showed acceptable results (p&lt;0.05). According to SVM for assessing the best model for prediction of response to therapy, GLCM entropy alone showed the highest predictive performance in treatment planning. For the entire cohort, the Kaplan-Meier test revealed a median OS of 21 months (95% CI: 12.12-29.88). The median OS was estimated at 26 months (95% CI: 17.43-34.56) for BCR patients and 13 months (95% CI: 9.18-16.81) for non BCR patients. Among all variables included in the Kaplan Meier, the only response to therapy was statistically significant (p=0.01). Conclusion This exploratory study showed that the heterogeneity parameter of pretreatment 68Ga-PSMA PET images might be a potential predictive value for response to 177Lu-PSMA therapy in mCRPC; however, further prospective studies need to be carried out to verify these findings." @default.
• W4311872728 created "2023-01-02" @default.
• W4311872728 creator A5009774150 @default.
• W4311872728 creator A5026041687 @default.
• W4311872728 creator A5032276703 @default.
• W4311872728 creator A5034422165 @default.
• W4311872728 creator A5038394289 @default.
• W4311872728 creator A5048541207 @default.
• W4311872728 creator A5056308686 @default.
• W4311872728 creator A5059480753 @default.
• W4311872728 creator A5062424480 @default.
• W4311872728 creator A5064777652 @default.
• W4311872728 creator A5071586528 @default.
• W4311872728 creator A5079511375 @default.
• W4311872728 date "2022-12-08" @default.
• W4311872728 modified "2023-10-14" @default.
• W4311872728 title "Predictive and prognostic potential of pretreatment 68Ga-PSMA PET tumor heterogeneity index in patients with metastatic castration-resistant prostate cancer treated with 177Lu-PSMA" @default.
• W4311872728 cites W1546799663 @default.
• W4311872728 cites W1997274003 @default.
• W4311872728 cites W2009936243 @default.
• W4311872728 cites W2026616100 @default.
• W4311872728 cites W2033973189 @default.
• W4311872728 cites W2069399470 @default.
• W4311872728 cites W2080232352 @default.
• W4311872728 cites W2302508993 @default.
• W4311872728 cites W2315998085 @default.
• W4311872728 cites W2515351720 @default.
• W4311872728 cites W2532226140 @default.
• W4311872728 cites W2612027160 @default.
• W4311872728 cites W2763355946 @default.
• W4311872728 cites W2781993955 @default.
• W4311872728 cites W2789890745 @default.
• W4311872728 cites W2809848353 @default.
• W4311872728 cites W2889646458 @default.
• W4311872728 cites W2889726085 @default.
• W4311872728 cites W2937444132 @default.
• W4311872728 cites W2950030754 @default.
• W4311872728 cites W2951387977 @default.
• W4311872728 cites W2981468397 @default.
• W4311872728 cites W3005237187 @default.
• W4311872728 cites W3007254442 @default.
• W4311872728 cites W3035720666 @default.
• W4311872728 cites W3046865842 @default.
• W4311872728 cites W3047132415 @default.
• W4311872728 cites W3115784662 @default.
• W4311872728 cites W3125281938 @default.
• W4311872728 cites W3133507743 @default.
• W4311872728 cites W3137730786 @default.
• W4311872728 cites W3162586049 @default.
• W4311872728 cites W3183560055 @default.
• W4311872728 cites W3186286798 @default.
• W4311872728 cites W3189516440 @default.
• W4311872728 cites W3210394817 @default.
• W4311872728 cites W4225535790 @default.
• W4311872728 doi "https://doi.org/10.3389/fonc.2022.1066926" @default.
• W4311872728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36568244" @default.
• W4311872728 hasPublicationYear "2022" @default.
• W4311872728 type Work @default.
• W4311872728 citedByCount "2" @default.
• W4311872728 countsByYear W43118727282023 @default.
• W4311872728 crossrefType "journal-article" @default.
• W4311872728 hasAuthorship W4311872728A5009774150 @default.
• W4311872728 hasAuthorship W4311872728A5026041687 @default.
• W4311872728 hasAuthorship W4311872728A5032276703 @default.
• W4311872728 hasAuthorship W4311872728A5034422165 @default.
• W4311872728 hasAuthorship W4311872728A5038394289 @default.
• W4311872728 hasAuthorship W4311872728A5048541207 @default.
• W4311872728 hasAuthorship W4311872728A5056308686 @default.
• W4311872728 hasAuthorship W4311872728A5059480753 @default.
• W4311872728 hasAuthorship W4311872728A5062424480 @default.
• W4311872728 hasAuthorship W4311872728A5064777652 @default.
• W4311872728 hasAuthorship W4311872728A5071586528 @default.
• W4311872728 hasAuthorship W4311872728A5079511375 @default.
• W4311872728 hasBestOaLocation W43118727281 @default.
• W4311872728 hasConcept C121608353 @default.
• W4311872728 hasConcept C126322002 @default.
• W4311872728 hasConcept C126894567 @default.
• W4311872728 hasConcept C12868164 @default.
• W4311872728 hasConcept C143998085 @default.
• W4311872728 hasConcept C2777008409 @default.
• W4311872728 hasConcept C2779466945 @default.
• W4311872728 hasConcept C2780192828 @default.
• W4311872728 hasConcept C2989005 @default.
• W4311872728 hasConcept C3019719930 @default.
• W4311872728 hasConcept C71924100 @default.
• W4311872728 hasConceptScore W4311872728C121608353 @default.
• W4311872728 hasConceptScore W4311872728C126322002 @default.
• W4311872728 hasConceptScore W4311872728C126894567 @default.
• W4311872728 hasConceptScore W4311872728C12868164 @default.
• W4311872728 hasConceptScore W4311872728C143998085 @default.
• W4311872728 hasConceptScore W4311872728C2777008409 @default.
• W4311872728 hasConceptScore W4311872728C2779466945 @default.
• W4311872728 hasConceptScore W4311872728C2780192828 @default.
• W4311872728 hasConceptScore W4311872728C2989005 @default.
• W4311872728 hasConceptScore W4311872728C3019719930 @default.
• W4311872728 hasConceptScore W4311872728C71924100 @default.
• W4311872728 hasLocation W43118727281 @default.
• W4311872728 hasLocation W43118727282 @default.
• W4311872728 hasLocation W43118727283 @default.
• W4311872728 hasOpenAccess W4311872728 @default.

• next