Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311873427> ?p ?o ?g. }
- W4311873427 abstract "Stem cells with the capacity of self-renewal and differentiation play pivotal roles in normal tissues and malignant tumors. Whereas stem cells are supposed to be genetically identical to their non-stem cell counterparts, cell stemness is deliberately regulated by a dynamic network of molecular mechanisms. Reversible post-translational protein modifications (PTMs) are rapid and reversible non-genetic processes that regulate essentially all physiological and pathological process. Numerous studies have reported the involvement of post-translational protein modifications in the acquirement and maintenance of cell stemness. Recent studies underscore the importance of protein sumoylation, i.e., the covalent attachment of the small ubiquitin-like modifiers (SUMO), as a critical post-translational protein modification in the stem cell populations in development and tumorigenesis. In this review, we summarize the functions of protein sumoylation in different kinds of normal and cancer stem cells. In addition, we describe the upstream regulators and the downstream effectors of protein sumoylation associated with cell stemness. We also introduce the translational studies aiming at sumoylation to target stem cells for disease treatment. Finally, we propose future directions for sumoylation studies in stem cells." @default.
- W4311873427 created "2023-01-02" @default.
- W4311873427 creator A5010959889 @default.
- W4311873427 creator A5028427087 @default.
- W4311873427 creator A5050147790 @default.
- W4311873427 creator A5082943131 @default.
- W4311873427 creator A5087848765 @default.
- W4311873427 date "2022-12-19" @default.
- W4311873427 modified "2023-10-01" @default.
- W4311873427 title "Protein sumoylation in normal and cancer stem cells" @default.
- W4311873427 cites W1528469482 @default.
- W4311873427 cites W1569027868 @default.
- W4311873427 cites W1846100490 @default.
- W4311873427 cites W1895732574 @default.
- W4311873427 cites W1964420018 @default.
- W4311873427 cites W1964611614 @default.
- W4311873427 cites W1964924844 @default.
- W4311873427 cites W1973776098 @default.
- W4311873427 cites W1975059674 @default.
- W4311873427 cites W1977179273 @default.
- W4311873427 cites W1977783851 @default.
- W4311873427 cites W1978693761 @default.
- W4311873427 cites W1989748254 @default.
- W4311873427 cites W1998294296 @default.
- W4311873427 cites W1999057135 @default.
- W4311873427 cites W2003299661 @default.
- W4311873427 cites W2009289802 @default.
- W4311873427 cites W2014643937 @default.
- W4311873427 cites W2020772572 @default.
- W4311873427 cites W2021044341 @default.
- W4311873427 cites W2022159597 @default.
- W4311873427 cites W2022249676 @default.
- W4311873427 cites W2028224002 @default.
- W4311873427 cites W2029194185 @default.
- W4311873427 cites W2035117805 @default.
- W4311873427 cites W2039490714 @default.
- W4311873427 cites W2043927273 @default.
- W4311873427 cites W2044559213 @default.
- W4311873427 cites W2047359222 @default.
- W4311873427 cites W2052211018 @default.
- W4311873427 cites W2073148985 @default.
- W4311873427 cites W2073590048 @default.
- W4311873427 cites W2084501381 @default.
- W4311873427 cites W2085649942 @default.
- W4311873427 cites W2089884508 @default.
- W4311873427 cites W2092857000 @default.
- W4311873427 cites W2094860066 @default.
- W4311873427 cites W2095839088 @default.
- W4311873427 cites W2102663142 @default.
- W4311873427 cites W2105247225 @default.
- W4311873427 cites W2105341311 @default.
- W4311873427 cites W2131426079 @default.
- W4311873427 cites W2134690343 @default.
- W4311873427 cites W2140484442 @default.
- W4311873427 cites W2145408676 @default.
- W4311873427 cites W2156022148 @default.
- W4311873427 cites W2158958901 @default.
- W4311873427 cites W2164467344 @default.
- W4311873427 cites W2191924043 @default.
- W4311873427 cites W2290873962 @default.
- W4311873427 cites W2310962685 @default.
- W4311873427 cites W2403686943 @default.
- W4311873427 cites W2473726130 @default.
- W4311873427 cites W2495454688 @default.
- W4311873427 cites W2557380926 @default.
- W4311873427 cites W2575706220 @default.
- W4311873427 cites W2581489880 @default.
- W4311873427 cites W2593074826 @default.
- W4311873427 cites W2605881103 @default.
- W4311873427 cites W2611197650 @default.
- W4311873427 cites W2729264850 @default.
- W4311873427 cites W2766585192 @default.
- W4311873427 cites W2772414594 @default.
- W4311873427 cites W2782519578 @default.
- W4311873427 cites W2797325437 @default.
- W4311873427 cites W2807426970 @default.
- W4311873427 cites W2807709055 @default.
- W4311873427 cites W2883163517 @default.
- W4311873427 cites W2883743258 @default.
- W4311873427 cites W2885330316 @default.
- W4311873427 cites W2895888408 @default.
- W4311873427 cites W2898290173 @default.
- W4311873427 cites W2900829812 @default.
- W4311873427 cites W2905380570 @default.
- W4311873427 cites W2907262475 @default.
- W4311873427 cites W2913395593 @default.
- W4311873427 cites W2914795103 @default.
- W4311873427 cites W2925210893 @default.
- W4311873427 cites W2946890982 @default.
- W4311873427 cites W2951289222 @default.
- W4311873427 cites W2956906556 @default.
- W4311873427 cites W2968185949 @default.
- W4311873427 cites W2982897014 @default.
- W4311873427 cites W2992974073 @default.
- W4311873427 cites W3021148844 @default.
- W4311873427 cites W3033323818 @default.
- W4311873427 cites W3037001968 @default.
- W4311873427 cites W3041157803 @default.
- W4311873427 cites W3085988699 @default.
- W4311873427 cites W3087249279 @default.