Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311881500> ?p ?o ?g. }
- W4311881500 abstract "The directed migration of cellular clusters enables morphogenesis, wound healing and collective cancer invasion. Gradients of substrate stiffness direct the migration of cellular clusters in a process called collective durotaxis, but the underlying mechanisms remain unclear. Here we unveil a connection between collective durotaxis and the wetting properties of cellular clusters. We show that clusters of cancer cells dewet soft substrates and wet stiff ones. At intermediate stiffness—at the crossover from low to high wettability—clusters on uniform-stiffness substrates become maximally motile, and clusters on stiffness gradients exhibit optimal durotaxis. Durotactic velocity increases with cluster size, stiffness gradient and actomyosin activity. We demonstrate this behaviour on substrates coated with the cell–cell adhesion protein E-cadherin and then establish its generality on substrates coated with extracellular matrix. We develop an active wetting model that explains collective durotaxis in terms of a balance between in-plane active traction and tissue contractility and out-of-plane surface tension. Finally, we show that the distribution of cluster displacements has a heavy tail, with infrequent but large cellular hops that contribute to durotactic migration. Our study demonstrates a physical mechanism of collective durotaxis, through both cell–cell and cell–substrate adhesion ligands, based on the wetting properties of active droplets. Substrate stiffness influences cellular cluster migration through collective durotaxis. Now, the underlying mechanism of this process is explained by considering the wetting dynamics of the clusters." @default.
- W4311881500 created "2023-01-02" @default.
- W4311881500 creator A5005024990 @default.
- W4311881500 creator A5007165670 @default.
- W4311881500 creator A5026108546 @default.
- W4311881500 creator A5027994094 @default.
- W4311881500 creator A5038482358 @default.
- W4311881500 creator A5038786709 @default.
- W4311881500 creator A5066691130 @default.
- W4311881500 creator A5069927259 @default.
- W4311881500 creator A5085198855 @default.
- W4311881500 creator A5090541007 @default.
- W4311881500 creator A5091417446 @default.
- W4311881500 date "2022-12-08" @default.
- W4311881500 modified "2023-10-16" @default.
- W4311881500 title "Stiffness-dependent active wetting enables optimal collective cell durotaxis" @default.
- W4311881500 cites W1626095167 @default.
- W4311881500 cites W1869516088 @default.
- W4311881500 cites W1971739638 @default.
- W4311881500 cites W1986197523 @default.
- W4311881500 cites W1988344228 @default.
- W4311881500 cites W1990905558 @default.
- W4311881500 cites W2003331194 @default.
- W4311881500 cites W2011650280 @default.
- W4311881500 cites W2011684391 @default.
- W4311881500 cites W2012325092 @default.
- W4311881500 cites W2014809662 @default.
- W4311881500 cites W2018258430 @default.
- W4311881500 cites W2023305433 @default.
- W4311881500 cites W2024250498 @default.
- W4311881500 cites W2029046412 @default.
- W4311881500 cites W2035336687 @default.
- W4311881500 cites W2040923825 @default.
- W4311881500 cites W2045213514 @default.
- W4311881500 cites W2048263630 @default.
- W4311881500 cites W2055919941 @default.
- W4311881500 cites W2057499308 @default.
- W4311881500 cites W2064701030 @default.
- W4311881500 cites W2069202441 @default.
- W4311881500 cites W2069485614 @default.
- W4311881500 cites W2079790070 @default.
- W4311881500 cites W2079861054 @default.
- W4311881500 cites W2080056117 @default.
- W4311881500 cites W2081910439 @default.
- W4311881500 cites W2082231922 @default.
- W4311881500 cites W2083796374 @default.
- W4311881500 cites W2089109453 @default.
- W4311881500 cites W2093395964 @default.
- W4311881500 cites W2097970956 @default.
- W4311881500 cites W2102726388 @default.
- W4311881500 cites W2105762638 @default.
- W4311881500 cites W2124186838 @default.
- W4311881500 cites W2129232821 @default.
- W4311881500 cites W2131328415 @default.
- W4311881500 cites W2133566253 @default.
- W4311881500 cites W2138183010 @default.
- W4311881500 cites W2141075109 @default.
- W4311881500 cites W2147599162 @default.
- W4311881500 cites W2155143412 @default.
- W4311881500 cites W2161708949 @default.
- W4311881500 cites W2273560121 @default.
- W4311881500 cites W2327893020 @default.
- W4311881500 cites W2339643912 @default.
- W4311881500 cites W2415012192 @default.
- W4311881500 cites W2423234228 @default.
- W4311881500 cites W2513054915 @default.
- W4311881500 cites W2522847382 @default.
- W4311881500 cites W2560120179 @default.
- W4311881500 cites W2564026026 @default.
- W4311881500 cites W2738160504 @default.
- W4311881500 cites W2783892446 @default.
- W4311881500 cites W2788380830 @default.
- W4311881500 cites W2788630243 @default.
- W4311881500 cites W2794344018 @default.
- W4311881500 cites W2796138053 @default.
- W4311881500 cites W2895643069 @default.
- W4311881500 cites W2903449035 @default.
- W4311881500 cites W2909951354 @default.
- W4311881500 cites W2924438894 @default.
- W4311881500 cites W2945076939 @default.
- W4311881500 cites W2962056762 @default.
- W4311881500 cites W2971488563 @default.
- W4311881500 cites W2999312392 @default.
- W4311881500 cites W3007253077 @default.
- W4311881500 cites W3037148409 @default.
- W4311881500 cites W3049294517 @default.
- W4311881500 cites W3080101006 @default.
- W4311881500 cites W3094521351 @default.
- W4311881500 cites W3098725301 @default.
- W4311881500 cites W3099564404 @default.
- W4311881500 cites W3104301241 @default.
- W4311881500 cites W3111889784 @default.
- W4311881500 cites W3189399718 @default.
- W4311881500 cites W3209822761 @default.
- W4311881500 cites W3212427395 @default.
- W4311881500 cites W4200431799 @default.
- W4311881500 cites W4225930633 @default.
- W4311881500 cites W4241971838 @default.
- W4311881500 cites W4285005623 @default.
- W4311881500 cites W4292113017 @default.