Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311883472> ?p ?o ?g. }
- W4311883472 abstract "Protein concentrations are set by a complex interplay between gene-specific regulatory processes and systemic factors, including cell volume and shared gene expression machineries. Elucidating this interplay is crucial for discerning and designing gene regulatory systems. We quantitatively characterized gene-specific and systemic factors that affect transcription and translation genome-wide for Escherichia coli across many conditions. The results revealed two design principles that make regulation of gene expression insulated from concentrations of shared machineries: RNA polymerase activity is fine-tuned to match translational output, and translational characteristics are similar across most messenger RNAs (mRNAs). Consequently, in bacteria, protein concentration is set primarily at the promoter level. A simple mathematical formula relates promoter activities and protein concentrations across growth conditions, enabling quantitative inference of gene regulation from omics data." @default.
- W4311883472 created "2023-01-02" @default.
- W4311883472 creator A5012496568 @default.
- W4311883472 creator A5052704218 @default.
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- W4311883472 creator A5080459151 @default.
- W4311883472 creator A5088462649 @default.
- W4311883472 creator A5090320822 @default.
- W4311883472 date "2022-12-09" @default.
- W4311883472 modified "2023-10-13" @default.
- W4311883472 title "Principles of gene regulation quantitatively connect DNA to RNA and proteins in bacteria" @default.
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