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- W4311883962 endingPage "99" @default.
- W4311883962 startingPage "89" @default.
- W4311883962 abstract "Tropomyosin receptor kinase B (TrkB), a transmembrane receptor protein, has been found to play a pivotal role in neural development. This protein is encoded by the neurotrophic receptor tyrosine kinase 2 (NTRK2) gene, and its abnormal activation caused by NTRK2 overexpression or fusion can contribute to tumour initiation, progression, and resistance to therapeutics in multiple types of neurogenic tumours. Targeted therapies for this mechanism have been designed and developed in preclinical and clinical studies, including selective TrkB inhibitors and pan-TRK inhibitors. This review describes the gene structure, biological function, abnormal TrkB activation mechanism, and current-related targeted therapies in neurogenic tumours." @default.
- W4311883962 created "2023-01-02" @default.
- W4311883962 creator A5019935534 @default.
- W4311883962 creator A5046597133 @default.
- W4311883962 creator A5050833677 @default.
- W4311883962 creator A5059839384 @default.
- W4311883962 creator A5063354535 @default.
- W4311883962 date "2022-12-19" @default.
- W4311883962 modified "2023-10-13" @default.
- W4311883962 title "Tropomyosin receptor kinase B (<scp>TrkB</scp>) signalling: targeted therapy in neurogenic tumours" @default.
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