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- W4311884370 endingPage "1902" @default.
- W4311884370 startingPage "1902" @default.
- W4311884370 abstract "Cancer metabolic reprogramming is essential for maintaining cancer cell survival and rapid replication. A common target of this metabolic reprogramming is one-carbon metabolism which is notable for its function in DNA synthesis, protein and DNA methylation, and antioxidant production. Polyamines are a key output of one-carbon metabolism with widespread effects on gene expression and signaling. As a result of these functions, one-carbon and polyamine metabolism have recently drawn a lot of interest for their part in cancer malignancy. Therapeutic inhibitors that target one-carbon and polyamine metabolism have thus been trialed as anticancer medications. The significance and future possibilities of one-carbon and polyamine metabolism as a target in cancer therapy are discussed in this review." @default.
- W4311884370 created "2023-01-02" @default.
- W4311884370 creator A5045606585 @default.
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- W4311884370 creator A5062555307 @default.
- W4311884370 creator A5067679313 @default.
- W4311884370 date "2022-12-19" @default.
- W4311884370 modified "2023-09-26" @default.
- W4311884370 title "One-Carbon and Polyamine Metabolism as Cancer Therapy Targets" @default.
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