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• W4311892080 abstract "Abstract Three-dimensional (3D) human cell culture models have emerged as a key technology for personalized medicine and for phenotypic compound screening in more disease-like in-vitro systems. Mass spectrometry imaging (MSI) is one of the most versatile label-free techniques that enables simultaneous generation of spatial maps for multiple relevant molecules in these 3D-models. Here, we present an integrated platform for 3D-MSI of 3D-cell cultures comprising 3D-printed metal casting molds for freezing and embedding, MS imaging of 100 serial cryosections and their computational elastic 3D-reconstruction. With this platform, we monitored multiple lipids that were selectively associated with different cell-types or cell-cell interactions within 300 μm-scale fibroblast and colon cancer biculture spheroids. Our findings suggest that 3D-printing-aided precise preparation of serial sections from small spheroids and visualization of marker molecules in 3D can provide a detailed overview of the cellular metabolic interplay in 3D cell culture models in cancer research and drug discovery." @default.
• W4311892080 created "2023-01-02" @default.
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• W4311892080 date "2022-12-08" @default.
• W4311892080 modified "2023-10-14" @default.
• W4311892080 title "3D-Mass Spectrometry Imaging of Micro-scale 3D Cell Culture Models in Cancer Research" @default.
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• W4311892080 doi "https://doi.org/10.1101/2022.12.05.519157" @default.
• W4311892080 hasPublicationYear "2022" @default.
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