Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311894724> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4311894724 endingPage "74" @default.
- W4311894724 startingPage "66" @default.
- W4311894724 abstract "p90 Ribosomal S6 kinase 2 (RSK2), a member of mitogen-activated protein kinase regulating cell proliferation and transformation induced by tumor promoters, such as epidermal growth factor, plays a vital role as a signaling hub to modulate cell proliferation, transformation, cell cycle transition, and chromatin remodeling by tumor promoter stimulation such as epidermal growth factor. On the other hand, the RSK2-mediated signaling networks that regulate cancer cell proliferation are unclear. In this study, SKOV3, an ovarian cancer cell that exhibits chemoresistant properties, and TOV-112D cells showed different sensitivities to colony growth in soft agar. Based on the protein profile shown in a previous report, RSK2 knockdown preferentially and significantly suppressed cell proliferation and colony growth. Moreover, RSK2 interacted with AKTs (AKT 1-3) via the N-terminal kinase domain (NTKD) of RSK2, resulting in the phosphorylation of RSK2. The AKT-mediated phosphorylation consensus sequence, RxRxxS/T, on RSK2 NTKD (Thr115) was well conserved in different species. In particular, an in vitro kinase assay showed that NTKD deleted and Thr115Ala mutants of RSK2 abolished AKT1-mediated phosphorylation. In the physiological assay of RSK2 phosphorylation at Thr115 on cell proliferation, AKT1-mediated RSK2 phosphorylation at Thr115 played an essential role in cell proliferation. The re-introduction of RSK2-T115A to RSK2−/− MEF attenuated the EGF-induced G1/S cell cycle transition compared to RSK2-wt introducing RSK2−/− MEFs. This attenuation was observed by EGF stimulations and insulin-like growth factor-1. Overall, these results show that novel wiring of the AKT/RSKs signaling axis plays an important role in cancer cell proliferation by modulating the G1/S cell cycle transition." @default.
- W4311894724 created "2023-01-02" @default.
- W4311894724 creator A5083086043 @default.
- W4311894724 creator A5083524882 @default.
- W4311894724 date "2023-01-01" @default.
- W4311894724 modified "2023-09-26" @default.
- W4311894724 title "Novel wiring of the AKT-RSK2 signaling pathway plays an essential role in cancer cell proliferation via a G1/S cell cycle transition" @default.
- W4311894724 cites W1864862165 @default.
- W4311894724 cites W1945464539 @default.
- W4311894724 cites W1970728706 @default.
- W4311894724 cites W1987749499 @default.
- W4311894724 cites W1998203489 @default.
- W4311894724 cites W1998682097 @default.
- W4311894724 cites W2015714994 @default.
- W4311894724 cites W2028415754 @default.
- W4311894724 cites W2046845314 @default.
- W4311894724 cites W2060055959 @default.
- W4311894724 cites W2077673188 @default.
- W4311894724 cites W2087846936 @default.
- W4311894724 cites W2097041188 @default.
- W4311894724 cites W2110528825 @default.
- W4311894724 cites W2123342099 @default.
- W4311894724 cites W2130456575 @default.
- W4311894724 cites W2140117696 @default.
- W4311894724 cites W2145596289 @default.
- W4311894724 cites W2151258296 @default.
- W4311894724 cites W2159550051 @default.
- W4311894724 cites W2173590184 @default.
- W4311894724 cites W2562604312 @default.
- W4311894724 cites W2890465763 @default.
- W4311894724 cites W2996084518 @default.
- W4311894724 cites W3213076623 @default.
- W4311894724 doi "https://doi.org/10.1016/j.bbrc.2022.12.048" @default.
- W4311894724 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36566564" @default.
- W4311894724 hasPublicationYear "2023" @default.
- W4311894724 type Work @default.
- W4311894724 citedByCount "1" @default.
- W4311894724 countsByYear W43118947242023 @default.
- W4311894724 crossrefType "journal-article" @default.
- W4311894724 hasAuthorship W4311894724A5083086043 @default.
- W4311894724 hasAuthorship W4311894724A5083524882 @default.
- W4311894724 hasBestOaLocation W43118947241 @default.
- W4311894724 hasConcept C104202773 @default.
- W4311894724 hasConcept C11960822 @default.
- W4311894724 hasConcept C1491633281 @default.
- W4311894724 hasConcept C170493617 @default.
- W4311894724 hasConcept C184235292 @default.
- W4311894724 hasConcept C2776362946 @default.
- W4311894724 hasConcept C2780044377 @default.
- W4311894724 hasConcept C2780926556 @default.
- W4311894724 hasConcept C29537977 @default.
- W4311894724 hasConcept C55493867 @default.
- W4311894724 hasConcept C62112901 @default.
- W4311894724 hasConcept C62478195 @default.
- W4311894724 hasConcept C75217442 @default.
- W4311894724 hasConcept C86803240 @default.
- W4311894724 hasConcept C95444343 @default.
- W4311894724 hasConceptScore W4311894724C104202773 @default.
- W4311894724 hasConceptScore W4311894724C11960822 @default.
- W4311894724 hasConceptScore W4311894724C1491633281 @default.
- W4311894724 hasConceptScore W4311894724C170493617 @default.
- W4311894724 hasConceptScore W4311894724C184235292 @default.
- W4311894724 hasConceptScore W4311894724C2776362946 @default.
- W4311894724 hasConceptScore W4311894724C2780044377 @default.
- W4311894724 hasConceptScore W4311894724C2780926556 @default.
- W4311894724 hasConceptScore W4311894724C29537977 @default.
- W4311894724 hasConceptScore W4311894724C55493867 @default.
- W4311894724 hasConceptScore W4311894724C62112901 @default.
- W4311894724 hasConceptScore W4311894724C62478195 @default.
- W4311894724 hasConceptScore W4311894724C75217442 @default.
- W4311894724 hasConceptScore W4311894724C86803240 @default.
- W4311894724 hasConceptScore W4311894724C95444343 @default.
- W4311894724 hasFunder F4320321379 @default.
- W4311894724 hasFunder F4320322030 @default.
- W4311894724 hasLocation W43118947241 @default.
- W4311894724 hasLocation W43118947242 @default.
- W4311894724 hasOpenAccess W4311894724 @default.
- W4311894724 hasPrimaryLocation W43118947241 @default.
- W4311894724 hasRelatedWork W1974268113 @default.
- W4311894724 hasRelatedWork W2066142257 @default.
- W4311894724 hasRelatedWork W2083609600 @default.
- W4311894724 hasRelatedWork W2094806850 @default.
- W4311894724 hasRelatedWork W2298186262 @default.
- W4311894724 hasRelatedWork W2332811711 @default.
- W4311894724 hasRelatedWork W2532041 @default.
- W4311894724 hasRelatedWork W2766589798 @default.
- W4311894724 hasRelatedWork W3174420640 @default.
- W4311894724 hasRelatedWork W3194519802 @default.
- W4311894724 hasVolume "642" @default.
- W4311894724 isParatext "false" @default.
- W4311894724 isRetracted "false" @default.
- W4311894724 workType "article" @default.